Kinetic models reveal the interplay of protein production and aggregation.
J Wei, G Meisl, A Dear, M Oosterhuis, R Melki, C Emanuelsson, S Linse, TPJ Knowles
– Chemical Science
(2024)
15,
Pharmacological inhibition of α-synuclein aggregation within liquid condensates.
ST Dada, Z Toprakcioglu, MP Cali, A Röntgen, MC Hardenberg, OM Morris, LK Mrugalla, TPJ Knowles, M Vendruscolo
– Nature communications
(2024)
15,
Maximum entropy determination of mammalian proteome dynamics
AJ Dear, GA Garcia, G Meisl, GA Collins, TPJ Knowles, AL Goldberg
– Proceedings of the National Academy of Sciences of the United States of America
(2024)
121,
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed
AJ Dear, X Teng, SR Ball, J Lewin, RI Horne, D Clow, A Stevenson, N Harper, K Yahya, X Yang, SC Brewerton, J Thomson, TCT Michaels, S Linse, TPJ Knowles, J Habchi, G Meisl
– Chemical science
(2024)
15,
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
TL Chris Ng, M Hoare, J Maristany, E Wilde, T Sneideris, J Huertas, B Agbetiameh, M Furukawa, J Joseph, TPJ Knowles, R Collepardo-Guevara, L Itzhaki, J Kumita
(2024)
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
RI Horne, EA Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo
– Nature chemical biology
(2024)
20,
Selenium-silk microgels as antifungal and antibacterial agents †
EG Wiita, Z Toprakcioglu, AK Jayaram, TPJ Knowles
– Nanoscale Horiz
(2024)
9,
Abstract 4891: Discovery of novel biomolecular condensate drug targets in oncology using in silico predictive tools
KL Saar, M Rebmann, M Kanchwala, S Qamar, P Radhakrishnan, J Cornish, J Doh, J Cattin, A Rotem, M Ghandi, A Seeber, RC Centore, SA Teichmann, T Knowles, S Arora
– Cancer Research
(2024)
84,
Abstract 1657: Microfluidics-based screening platform identifies a novel therapeutic approach to targeting EML4-ALK driven cancers
RC Centore, M Watson, J Doh, J Cattin, C Sgambato, A Alex, J Sawant, P Radhakrishnan, J Cornish, A Howarth, N Bharatham, WE Arter, S Qamar, KL Saar, D Williamson, A Seeber, N Groenewegen, M Czekalska, T Kartanas, N Ermann, A Taher, T Knowles, S Arora
– Cancer Research
(2024)
84,
Abstract 3231: Pharmacological inhibition of the m6A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer
RC Centore, M Charles, M Arora, Y Chen, M Watson, C Kelley, M Czekalska, M Rebmann, M Ghandi, J Cattin, N Bharatham, P Radhakrishnan, A Howarth, G Rudlaff, WE Arter, S Qamar, K Saar, D Williamson, A Seeber, T Knowles, S Arora
– Cancer Research
(2024)
84,
