Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of lactols.
– Synlett
(1998)
1998,
1091
(doi: 10.1055/s-1998-1866)
(1′S,2′S)-methyl-3O,4O-(1′,2′-dimethoxycyclohexane-1′,2′-diyl)-α-D-mannopyranoside
– ORGANIC SYNTHESES, VOL 75
(1998)
75,
170
(doi: 10.15227/orgsyn.075.0170)
Tricarbonyliron complexes: An approach to acyclic stereocontrol
– Chemical Society Reviews
(1998)
27,
301
(doi: 10.1039/a827301z)
Diastereoselective anomeric oxygen to carbon rearrangements of silyl enol ether derivatives of lactols
– Synlett
(1998)
1998,
1093
(doi: 10.1055/s-1998-1867)
One-pot Synthesis of Penta- and Hepta-saccharides from Monomeric Mannose Building Blocks Using the Principles of Orthogonality and Reactivity Tuning
– Synlett
(1998)
1998,
440
(doi: 10.1055/s-1998-1659)
Studies Towards the Synthesis of the C29-C51 Fragment of Altohyrtin A
– Synlett
(1998)
1998,
991
(doi: 10.1055/s-1998-3140)
Enantioselective aldol reactions of α-unsubstituted enol ether derivatives catalyzed by a chiral Ti(IV) complex
– Chemtracts
(1997)
10,
853
1,5-Asymmetric induction of chirality: highly diastereoselective synthesis of homoallylic tertiary alcohols by the Lewis acid-mediated addition of allylstannanes into ketones in the side-chain of pi-allyltricarbonyliron lactone complexes
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1997)
3315
(doi: 10.1039/a704491g)
Tetra- n -propylammonium perruthenate (TPAP)-catalysed oxidations of alcohols using molecular oxygen as a co-oxidant
– Journal of the Chemical Society, Perkin Transactions 1
(1997)
3291
(doi: 10.1039/a707339i)
1,5-Asymmetric induction of chirality: Highly diastereoselective addition reactions of organoaluminium reagents into ketone groups in the side-chain of π-allyltricarbonyliron lactone complexes
– Journal of the Chemical Society Perkin Transactions 1
(1997)
3299
(doi: 10.1039/a704481j)
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