Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Stereoelectronic effects in the reactions of conformationally restricted, substituted cyclohexane-1,2-diones with 1,2-diols
– Tetrahedron Asymmetry
(1998)
9,
2471
Mukaiyama aldol reactions of pi-allyltricarbonyliron lactone and lactam complexes bearing trimethylsilyl enol ether side-chains. Not just formal, but genuine 1,7 induction of chirality
– Chemical Communications
(1998)
1339
(doi: 10.1039/a802878h)
Highly diasteroselective synthesis of β-hydroxy carbonyl compounds using π-allyltricarbonyliron lactone complexes:: a formal 1,7-asymmetric induction of chirality in a Mukaiyama aldol reaction (pg 227, 1998)
– CHEM COMMUN
(1998)
851
A novel decomplexation of pi-allyltricarbonyliron lactone complexes using borohydride reagents: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols (pg 229, 1998)
– CHEM COMMUN
(1998)
851
A novel decomplexation of π-allyltricarbonyliron lactone complexes using borohydride reagents: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols
– Chemical Communications
(1998)
229
(doi: 10.1039/a707155h)
Highly diastereoselective synthesis of β-hydroxy carbonyl compounds using π-allyltricarbonyliron lactone complexes: a formal 1,7-asymmetric induction of chirality in a Mukaiyama aldol reaction
– Chemical Communications
(1998)
227
(doi: 10.1039/a707153a)
Synthesis of isoxazolidines using polymer supported perruthenate (PSP)
– Journal of the Chemical Society, Perkin Transactions 1
(1998)
1
(doi: 10.1039/a707340b)
Tuning glycoside reactivity: New tool for efficient oligosaccharide synthesis
– Journal of the Chemical Society Perkin Transactions 1
(1998)
51
(doi: 10.1039/a705275h)
Diastereoselective anomeric oxygen to carbon rearrangements of silyl enol ether derivatives of lactols
– Synlett
(1998)
1998,
1093
(doi: 10.1055/s-1998-1867)
Anomeric Oxygen to Carbon Rearrangements of Alkynyl Tributylstannane Derivatives of Lactols
– Synlett
(1998)
1998,
1091
(doi: 10.1055/s-1998-1866)
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