Yusuf Hamied Department of Chemistry

Dr Shekhar Kedia

Research Associate

My research interests lie in understanding the nanoscale triggers of neurodegenerative disorders using biophysical approaches and how these alterations at the synapses contribute towards the onset of such diseases. It was piqued during my PhD research and continues to grow within postdoctoral research. I am attempting to address the challenges associated with rapid extraction and nanoscale imaging of synapses from brain tissues.

Publications

Early synaptic pathology is associated with small tau aggregates in Alzheimer's disease.
E Fertan, S Kedia, G Nolan, G Meisl, MW Cotton, KH Müller, Z Zhang, L Muresan, A Quaegebeur, MG Spillantini, D Klenerman
Acta neuropathologica
(2026)
151
(doi: 10.1007/s00401-026-02977-9)
Rethinking neurodegeneration through a co-proteinopathy lens
YP Zhang, S Kedia, D Klenerman
Trends Neurosci
(2025)
48
(doi: 10.1016/j.tins.2025.10.006)
Early synaptic pathology is associated with small tau aggregates in Alzheimer’s disease
E Fertan, S Kedia, G Meisl, MW Cotton, A Quaegebeur, MG Spillantini, D Klenerman
(2025)
(doi: 10.1101/2025.09.13.676039)
T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts
M Kotowski, DF Heraghty, M Körbel, D Banik, Z Zhang, S Kedia, B Fu, J McColl, B Li, J Clarke, M Fellermeyer, Y Lui, G Bossi, DK Cole, H Chen, E Basiarz, S Sharma, E Petsalaki, CJ Tape, B de Wet, SF Lee, AM Santos, D Klenerman, SJ Davis
(2025)
(doi: 10.1101/2025.08.29.673015)
Nanoscale Lattice Organization of Molecular Condensates Drives Compositional Degeneracy in Synaptic Plasticity
PR Netrakanti, Y Chopra, R Agarwal, P Rajeev, S Kedia, M Jose, S Nadkarni, D Nair
(2025)
(doi: 10.1101/2025.03.14.641702)
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
S Kedia, E Fertan, Y Wu, YP Zhang, G Meisl, JYL Lam, F K Wiseman, WA McEwan, A Quaegebeur, MG Spillantini, JSH Danial, D Klenerman
Cell chemical biology
(2025)
32
(doi: 10.1016/j.chembiol.2025.01.001)
A human neuronal model of sporadic Alzheimer’s disease induced by FBXO2 downregulation shows Aβ aggregation, tau hyperphosphorylation and functional network impairment
AG Díaz, A Possenti, GA Urrutia, Y Bian, S Kedia, D Boeken, CM Lim, D Licastro, B Mannini, D Klenerman, M Vendruscolo
(2024)
(doi: 10.1101/2024.09.01.610673)
Hyaluronidase unlocks sequestered CEACAM5 and improves CAR T-cell therapy in colorectal cancer
D Banik, C Ward, Z Zhang, S Chakraborty, D Heraghty, P Suresh, B Li, S Kedia, SJ Davis, JP Roy, MA Chapman, B Mahata, D Klenerman
(2024)
(doi: 10.1101/2024.08.29.610222)
SynPull: a novel method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
S Kedia, E Fertan, Y Wu, YP Zhang, G Meisl, JYL Lam, F Wiseman, WA McEwan, A Quaegebeur, MG Spillantini, JSH Danial, D Klenerman
(2024)
(doi: 10.1101/2024.08.24.609517)
The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide
B Li, P Suresh, J Brelstaff, S Kedia, CE Bryant, D Klenerman
eLife
(2024)
13
(doi: 10.7554/elife.92350.3)

Research Group

Telephone number

01223 763965

Email address

sk2226@cam.ac.uk
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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