Dr Shekhar Kedia

Research Associate

My research interests lie in understanding the nanoscale triggers of neurodegenerative disorders using biophysical approaches and how these alterations at the synapses contribute towards the onset of such diseases. It was piqued during my PhD research and continues to grow within postdoctoral research. I am attempting to address the challenges associated with rapid extraction and nanoscale imaging of synapses from brain tissues.

Publications

Cross-Species Aging Knowledge Integration into Agentic AI Platform Uncovers Conserved Mechanisms

G Ahuja, A Sharma, A Singh, S Kedia, A Sharma, V Gautam, P Sharma, A Khandelwal, S Ramakrishna, R Muddashetty, K Freude, S Solanki, S Chauhan, S Kumar, S Satija, S Duari, S Arora, A Gupta, R Shome, D Sengupta, D nair

(2026)

(doi: 10.21203/rs.3.rs-9060414/v1)

Assessing the impact of mono- and bi-allelic deletions in NRXN1 on synaptic function

A Massrali, A Paul, R Matuleviciute, NJ Gatford, L Dutan-Polit, S Kedia, S Rahman, DP Srivastava, M Kotter, D Adhya, S Baron-Cohen

(2026)

(doi: 10.64898/2026.02.20.707024)

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti-CEACAM5 CAR T-Cell Efficacy Against Colorectal Cancer

D Banik, CJ Ward, S Chakraborty, Z Zhang, D Heraghty, P Suresh, B Li, S Kedia, J Pramanik, SJ Davis, JP Roy, MA Chapman, B Mahata, D Klenerman

Advanced Science

(2026)

e09762

(doi: 10.1002/advs.202509762)

Rethinking neurodegeneration through a co-proteinopathy lens.

YP Zhang, S Kedia, D Klenerman

Trends in Neurosciences

(2025)

952

(doi: 10.1016/j.tins.2025.10.006)

Early synaptic pathology is associated with small tau aggregates in Alzheimer’s disease

E Fertan, S Kedia, G Meisl, MW Cotton, A Quaegebeur, MG Spillantini, D Klenerman

(2025)

(doi: 10.1101/2025.09.13.676039)

T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts

M Kotowski, DF Heraghty, M Körbel, D Banik, Z Zhang, S Kedia, B Fu, J McColl, B Li, J Clarke, M Fellermeyer, Y Lui, G Bossi, DK Cole, H Chen, E Basiarz, S Sharma, E Petsalaki, CJ Tape, B de Wet, SF Lee, AM Santos, D Klenerman, SJ Davis

(2025)

(doi: 10.1101/2025.08.29.673015)

Nanoscale Lattice Organization of Molecular Condensates Drives Compositional Degeneracy in Synaptic Plasticity

PR Netrakanti, Y Chopra, R Agarwal, P Rajeev, S Kedia, M Jose, S Nadkarni, D Nair

(2025)

(doi: 10.1101/2025.03.14.641702)

SynPull: a novel method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy

S Kedia, E Fertan, Y Wu, YP Zhang, G Meisl, JYL Lam, F K Wiseman, WA McEwan, A Quaegebeur, MG Spillantini, JSH Danial, D Klenerman

Cell Chemical Biology

(2025)

338

(doi: 10.1016/j.chembiol.2025.01.001)

A human neuronal model of sporadic Alzheimer’s disease induced byFBXO2downregulation shows Aβ aggregation, tau hyperphosphorylation and functional network impairment

AG Díaz, A Possenti, GA Urrutia, Y Bian, S Kedia, D Boeken, CM Lim, D Licastro, B Mannini, D Klenerman, M Vendruscolo

(2024)

(doi: 10.1101/2024.09.01.610673)