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Yusuf Hamied Department of Chemistry

 

Dr Shekhar Kedia

Research Associate

My research interests lie in understanding the nanoscale triggers of neurodegenerative disorders using biophysical approaches and how these alterations at the synapses contribute towards the onset of such diseases. It was piqued during my PhD research and continues to grow within postdoctoral research. I am attempting to address the challenges associated with rapid extraction and nanoscale imaging of synapses from brain tissues.

Publications

The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide
B Li, P Suresh, J Brelstaff, S Kedia, CE Bryant, D Klenerman
(2024)
(doi: 10.7554/elife.92350)
The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide
B Li, P Suresh, J Brelstaff, S Kedia, CE Bryant, D Klenerman
– eLife
(2024)
13,
(doi: 10.7554/elife.92350.3)
Real-time heterogeneity of supramolecular assembly of amyloid precursor protein is modulated by an endocytic risk factor PICALM.
V Belapurkar, HS Mahadeva Swamy, N Singh, S Kedia, SRG Setty, M Jose, D Nair
– Cellular and molecular life sciences : CMLS
(2023)
80,
295
(doi: 10.1007/s00018-023-04939-w)
Golgi fragmentation - One of the earliest organelle phenotypes in Alzheimer's disease neurons.
H Haukedal, GI Corsi, VP Gadekar, NT Doncheva, S Kedia, N de Haan, A Chandrasekaran, P Jensen, P Schiønning, S Vallin, FR Marlet, A Poon, C Pires, FK Agha, HH Wandall, S Cirera, AH Simonsen, TT Nielsen, JE Nielsen, P Hyttel, R Muddashetty, BI Aldana, J Gorodkin, D Nair, M Meyer, MR Larsen, K Freude
– Frontiers in Neuroscience
(2023)
17,
1120086
(doi: 10.3389/fnins.2023.1120086)
Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains
S Kedia, K Mandal, PR Netrakanti, M Jose, SS Sisodia, D Nair
– Molecular brain
(2021)
14,
158
(doi: 10.1186/s13041-021-00855-x)
Quantifying molecular aggregation by super resolution microscopy within an excitatory synapse from mouse hippocampal neurons
S Kedia, N Ramanan, D Nair
– STAR protocols
(2021)
2,
100470
(doi: 10.1016/j.xpro.2021.100470)
Does Altered Probability of Real Time Diffusional Collisions of Membrane Molecules Trigger or Delay Alzheimers Disease
D Nair, S Kedia, M Jose
– iScience Notes
(2020)
5,
1
(doi: 10.22580/iscinotej5.5.3)
Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease
S Kedia, P Ramakrishna, PR Netrakanti, N Singh, SS Sisodia, M Jose, S Kumar, A Mahadevan, N Ramanan, S Nadkarni, D Nair
– iScience
(2020)
24,
101924
(doi: 10.1016/j.isci.2020.101924)
Nanoscale rearrangement of APP organization as a therapeutic target for Alzheimer's disease.
S Kedia, D Nair
– Med Hypotheses
(2020)
143,
110143
(doi: 10.1016/j.mehy.2020.110143)
Real-time nanoscale organization of amyloid precursor protein
S Kedia, P Ramakrishna, PR Netrakanti, M Jose, J-B Sibarita, S Nadkarni, D Nair
– Nanoscale
(2020)
12,
8200
(doi: 10.1039/d0nr00052c)

Research Group

Telephone number

01223 763965

Email address

sk2226@cam.ac.uk

    Study at Cambridge

    About the University

    Research at Cambridge