Research Associate
My research interests lie in understanding the nanoscale triggers of neurodegenerative disorders using biophysical approaches and how these alterations at the synapses contribute towards the onset of such diseases. It was piqued during my PhD research and continues to grow within postdoctoral research. I am attempting to address the challenges associated with rapid extraction and nanoscale imaging of synapses from brain tissues.
Publications
Real-time heterogeneity of supramolecular assembly of amyloid precursor protein is modulated by an endocytic risk factor PICALM.
– Cellular and molecular life sciences : CMLS
(2023)
80,
295
(doi: 10.1007/s00018-023-04939-w)
Golgi fragmentation - One of the earliest organelle phenotypes in Alzheimer's disease neurons
– Frontiers in Neuroscience
(2023)
17,
1120086
(doi: 10.3389/fnins.2023.1120086)
Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains
– Molecular brain
(2021)
14,
158
(doi: 10.1186/s13041-021-00855-x)
Quantifying molecular aggregation by super resolution microscopy within an excitatory synapse from mouse hippocampal neurons
– STAR protocols
(2021)
2,
100470
(doi: 10.1016/j.xpro.2021.100470)
Does Altered Probability of Real Time Diffusional Collisions of Membrane Molecules Trigger or Delay Alzheimers Disease
– iScience Notes
(2020)
5,
1
(doi: 10.22580/iscinotej5.5.3)
Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease
– iScience
(2020)
24,
101924
(doi: 10.1016/j.isci.2020.101924)
Nanoscale rearrangement of APP organization as a therapeutic target for Alzheimer's disease
– Med Hypotheses
(2020)
143,
110143
(doi: 10.1016/j.mehy.2020.110143)
Real-time nanoscale organization of amyloid precursor protein.
– Nanoscale
(2020)
12,
8200
(doi: 10.1039/d0nr00052c)