Dr Shekhar Kedia

Research Associate

My research interests lie in understanding the nanoscale triggers of neurodegenerative disorders using biophysical approaches and how these alterations at the synapses contribute towards the onset of such diseases. It was piqued during my PhD research and continues to grow within postdoctoral research. I am attempting to address the challenges associated with rapid extraction and nanoscale imaging of synapses from brain tissues.

Publications

The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS

B Li, P Suresh, J Brelstaff, S Kedia, C Bryant, D Klenerman

(2023)

(doi: 10.1101/2023.09.28.559977)

Real-time heterogeneity of supramolecular assembly of amyloid precursor protein is modulated by an endocytic risk factor PICALM.

V Belapurkar, HS Mahadeva Swamy, N Singh, S Kedia, SRG Setty, M Jose, D Nair

Cell Mol Life Sci

(2023)

295

(doi: 10.1007/s00018-023-04939-w)

Golgi fragmentation – One of the earliest organelle phenotypes in Alzheimer’s disease neurons

H Haukedal, GI Corsi, VP Gadekar, NT Doncheva, S Kedia, N de Haan, A Chandrasekaran, P Jensen, P Schiønning, S Vallin, FR Marlet, A Poon, C Pires, FK Agha, HH Wandall, S Cirera, AH Simonsen, TT Nielsen, JE Nielsen, P Hyttel, R Muddashetty, BI Aldana, J Gorodkin, D Nair, M Meyer, MR Larsen, K Freude

Frontiers in neuroscience

(2023)

1120086

(doi: 10.3389/fnins.2023.1120086)

Golgi fragmentation - One of the earliest organelle phenotypes in Alzheimer’s disease neurons

(2022)

(doi: 10.1101/2022.12.09.519571)

Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains.

S Kedia, K Mandal, PR Netrakanti, M Jose, SS Sisodia, D Nair

Molecular Brain

(2021)

158