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Dr Pietro Sormanni

Pietro obtained his BSc and a MSc in theoretical physics at the University of Milan (Italy) and spent the final year of his BSc studies in London at Queen Mary University and UCL. In January 2016, he obtained a PhD in chemistry from the University of Cambridge, working under the supervision of Prof Michele Vendruscolo at the Centre for Misfolding Diseases, where he currently works as a postdoctoral researcher.

Pietro’s research focuses on the development and applications of computational methods to predict and modify the behaviour of proteins, with a particular interest in developing novel technologies for the rational design of antibodies for research and therapeutic purposes. His publications and two filed patents in the area are at the basis of numerous academic and industrial collaborations that explore the potential of the in silico approach to streamline drug development, and to generate practically useful antibodies to address questions and accelerate discoveries in biomedical sciences.

Publications

A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.
MN Bongiovanni, FA Aprile, P Sormanni, M Vendruscolo
– International journal of molecular sciences
(2018)
19,
ARTN 1443
Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity
T Le Marchand, M de Rosa, N Salvi, BM Sala, LB Andreas, E Barbet-Massin, P Sormanni, A Barbiroli, R Porcari, C Sousa Mota, D de Sanctis, M Bolognesi, L Emsley, V Bellotti, M Blackledge, C Camilloni, G Pintacuda, S Ricagno
– Nature Communications
(2018)
9,
1658
Parapred: Antibody Paratope Prediction using Convolutional and Recurrent Neural Networks.
E Liberis, P Velickovic, P Sormanni, M Vendruscolo, P Liò
– Bioinformatics (Oxford, England)
(2018)
Corneal Dystrophy Mutations Drive Pathogenesis by Targeting TGFBIp Stability and Solubility in a Latent Amyloid-forming Domain.
M Stenvang, NP Schafer, KG Malmos, A-MW Pérez, O Niembro, P Sormanni, RV Basaiawmoit, G Christiansen, M Andreasen, DE Otzen
– Journal of molecular biology
(2018)
430,
1116
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
– J Neurosci Methods
(2018)
306,
57
Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo.
N Martínez-Sáez, S Sun, D Oldrini, P Sormanni, O Boutureira, F Carboni, I Compañón, MJ Deery, M Vendruscolo, F Corzana, R Adamo, GJL Bernardes
– Angew Chem Int Ed Engl
(2017)
56,
14963
MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins
D Piovesan, F Tabaro, L Paladin, M Necci, I Micetic, C Camilloni, N Davey, Z Dosztányi, B Mészáros, AM Monzon, G Parisi, E Schad, P Sormanni, P Tompa, M Vendruscolo, WF Vranken, SCE Tosatto
– Nucleic acids research
(2018)
46,
D471
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles
M Perni, FA Aprile, S Casford, B Mannini, P Sormanni, CM Dobson, M Vendruscolo
– Scientific reports
(2017)
7,
15045
Rapid and accurate in silico solubility screening of a monoclonal antibody library.
P Sormanni, L Amery, S Ekizoglou, M Vendruscolo, B Popovic
– Scientific reports
(2017)
7,
8200
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
– Sci Adv
(2017)
3,
e1700488
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Research Group

Telephone number

01223 763845 (shared)
36366 (shared)

Email address

ps589@cam.ac.uk

College

Clare Hall