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Yusuf Hamied Department of Chemistry

Portrait of mjg32

New Catalytic Strategies for Chemical Synthesis

Despite the changing face of chemistry, the importance of synthesis - the ability to generate molecules in a controlled fashion - has not diminished. However, the increasingly complex synthetic problems being posed by nature, medicine and materials demand new reactivity concepts and strategies in order to meet these challenges.

Our group is interested in the development of new catalytic strategies for chemical synthesis that engage novel reactivity concepts to enable the rapid generation of architecturally complex molecules and natural products. One of our key aims is to be able to construct natural products from simple building blocks in a single step, without the need for reactivity inducing functional groups and with the ability to control the stereochemistry.

In this way, we hope to be able to develop a chemo-catalytic equivalent to Nature's biosynthetic machinery that will enable us to build any molecule we want. Our approach to this is focussed on three main research programmes:

(A) metal catalyzed C-H bond functionalization,

(B) catalytic asymmetric synthesis using small molecule organic catalysts,

(C) cascade strategies for natural product synthesis.

In addition to this, many of the molecules that we are able to synthesise have interesting biological properties, and so we are also able to develop chemical biology applications from our synthetic chemistry projects.

Professor Gaunt discusses his research

Take a tour of the Yusuf Hamied Lab for Chemical Synthesis & Catalysis


New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines
A Trowbridge, SM Walton, MJ Gaunt
– Chemical Reviews
Rapid Syntheses of (−)‐FR901483 and (+)‐TAN1251C Enabled by Complexity‐Generating Photocatalytic Olefin Hydroaminoalkylation
D Reich, A Trowbridge, MJ Gaunt
– Angewandte Chemie - International Edition
Catalytic C(sp3)-H bond activation in tertiary alkylamines.
J Rodrigalvarez, M Nappi, H Azuma, NJ Flodén, ME Burns, MJ Gaunt
– Nature Chemistry
Palladium-Catalyzed C(sp(3))-H Bond Functionalization of Aliphatic Amines
C He, WG Whitehurst, MJ Gaunt
– Chem
Streamlined Synthesis of C(sp3)-Rich N-Heterospirocycles Enabled by Visible-Light-Mediated Photocatalysis.
N Flodén, A Trowbridge, M Gaunt, D Willcox, S Walton, Y Kim
– J Am Chem Soc
Carboxylate-Assisted Oxidative Addition to Aminoalkyl PdII Complexes: C(sp3 )-H Arylation of Alkylamines by Distinct PdII /PdIV Pathway.
MJ Gaunt, W Whitehurst, JH Blackwell, G Hermann
– Angewandte Chemie International Edition
Palladium(II)-Catalyzed C(sp (3) )-H Activation of N,O-Ketals towards a Method for the -Functionalization of Ketones
M Gaunt, D Ho, J Calleja
– Synlett
A class of N–O type oxidants to access high-valent palladium species
M Nappi, MJ Gaunt
– Organometallics
Mechanistic investigation into the C(sp 3 )–H acetoxylation of morpholinones
CS Buettner, D Willcox, BGN Chappell, MJ Gaunt
– Chemical Science
A protein functionalization platform based on selective reactions at methionine residues.
MT Taylor, JE Nelson, MG Suero, MJ Gaunt
– Nature
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01223 336318

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