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Professor Jonathan Nitschke

Portrait of jrn34

Figuring out the rules


We are interested in discovering and developing new ways in which simple building blocks may be induced to self-assemble into complex, functional structures. Our investigations currently focus upon the self-assembly of imine bonds around metal-ion templates, bringing both covalent C=N and coordinative N→Metal bonds into being during the same overall self-assembly process. The structures thus created can rearrange in well-defined ways at both covalent and coordinative linkages. Ongoing projects include:


 


Container Molecules. The diamine and aldehyde shown above self-assemble with iron(II) in water to form a tetrahedral cage. This cage traps guest molecules within its cavity with high selectivity. The cage may be opened and the guest released using different triggers, one of which is a drop in pH. Applications in drug delivery are of interest, as are investigations of changes in the reactivity and behaviour of guest molecules upon encapsulation.


 


Functional Materials. We have recently developed means to create metal-containing conjugated polymers through self-assembly. DFT calculations carried out by Laura Gagliardi and Christopher Cramer suggest that these might conduct electricity. Studies are thus being undertaken to investigate their properties.


Selected Publications


 


Feature Article: “Metal-organic container molecules through subcomponent self-assembly”, T.K. Ronson, S. Zarra, S.P. Black, J.R. Nitschke, Chem. Commun. 2013, 49, 2476-2490.


“Enantiopure Water-Soluble Fe4L6 Cages: Host-Guest Chemistry and Catalytic Activity”, Jeanne L. Bolliger, Ana M. Belenguer, and Jonathan R. Nitschke, Angew. Chem. Int. Ed. 2013, 52, 7958-7962.


“Aqueous Self-assembly of an Electroluminescent Double-helical Metallo-polymer”, X. de Hatten,  D. Asil, R.H. Friend, J.R. Nitschke,  J. Am. Chem. Soc. 2012, 135, 19170-19178.


“Anion-induced Reconstitution of a Self-assembling System to Express a Chloride-binding Co10L15 Pentagonal Prism”, I.A. Riddell, M.M.J. Smulders, J.K. Clegg, Y.R. Hristova, B. Breiner, J.D. Thoburn, J.R. Nitschke, Nature Chem. 2012, 51, 751-756.


 “White phosphorus is air-stable within a self-assembled tetrahedral capsule” P. Mal, B. Breiner, K. Rissanen and J.R. Nitschke, Science 2009, 324, 1697-1699.


“Systems chemistry: Molecular networks come of age” J.R. Nitschke, Nature 2009, 462, 736-738.

Publications

Signal transduction in a covalent post-assembly modification cascade
BS Pilgrim, DA Roberts, TG Lohr, TK Ronson, JR Nitschke
– Nature Chemistry
(2017)
9,
1276
Tuning the Redox Properties of Fullerene Clusters within a Metal–Organic Capsule
FJ Rizzuto, DM Wood, TK Ronson, JR Nitschke
– Journal of the American Chemical Society
(2017)
139,
11008
Excitation Energy Delocalization and Transfer to Guests within M
AJ Musser, P P Neelakandan, JM Richter, H Mori, RH Friend, JR Nitschke
– Journal of the American Chemical Society
(2017)
139,
12050
Anion Binding in Water Drives Structural Adaptation in an Azaphosphatrane-Functionalized (Fe4L4)-L-II Tetrahedron
D Zhang, TK Ronson, J Mosquera, A Martinez, L Guy, JR Nitschke
– Journal of the American Chemical Society
(2017)
139,
6574
Subcomponent Exchange Transforms an (Fe4L4)-L-II Cage from High- to Low-Spin, Switching Guest Release in a Two-Cage System
AJ McConnell, CM Aitchison, AB Grommet, JR Nitschke
– Journal of the American Chemical Society
(2017)
139,
6294
Stereochemical plasticity modulates cooperative binding in a Co
FJ Rizzuto, JR Nitschke
– Nature Chemistry
(2017)
9,
903
An Octanuclear Metallosupramolecular Cage Designed To Exhibit Spin-Crossover Behavior
N Struch, C Bannwarth, TK Ronson, Y Lorenz, B Mienert, N Wagner, M Engeser, E Bill, R Puttreddy, K Rissanen, J Beck, S Grimme, JR Nitschke, A Lützen
– Angew Chem Int Ed Engl
(2017)
56,
4930
Directed Phase Transfer of an (Fe4L4)-L-II Cage and Encapsulated Cargo
AB Grommet, JR Nitschke
– Journal of the American Chemical Society
(2017)
139,
2176
Separation and Selective Formation of Fullerene Adducts within an M(II)(8)L(6) Cage.
W Brenner, TK Ronson, JR Nitschke
– Journal of the American Chemical Society
(2017)
139,
75
Self-Assembly of Conjugated Metallopolymers with Tunable Length and Controlled Regiochemistry.
JL Greenfield, FJ Rizzuto, I Goldberga, JR Nitschke
– Angew Chem Int Ed Engl
(2017)
56,
7541
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Research Group

Research Interest Groups

Telephone number

01223 336324

Email address

jrn34@cam.ac.uk