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Professor Jeremy Sanders FRS

We are interested in molecular recognition, aiming to uncover and exploit the rules governing non-covalent interactions. Hydrophobic, π–π, donor–acceptor, metal– ligand and hydrogen bonding interactions are used to create new supramolecular systems that expand our understanding of molecular behaviour and may have useful recognition, catalytic or photophysical properties. In particular in the past few years we have developed the concept of dynamic combinatorial chemistry as a new approach for discovering entirely unexpected structures and assemblies. Over the years our building blocks have included peptides, metalloporphyrins, steroids and simple aromatics, and our products have included macrocycles, rotaxanes, catenanes, molecular knots and supramolecular nanotubes. Very recently, while investigating dynamic chemistry in the solid state using ball mill grinding, we have discovered solvent and surface effects on polymorph stability in nanocrystals

Please note that I am not taking any new students or postdocs into my research group.




Selected Publications


Evolution of dynamic combinatorial chemistry, Accounts Chem. Res., (2012), 45, 2211.

Discovery of an organic trefoil knot, Science, (2012), 338, 783.

Templated dynamic synthesis of a [3]Catenane, Angew. Chemie Intl. Edn., (2012), 51, 1443.

Thermodynamics of supramolecular naphthalenediimide nanotubes, J. Am. Chem. Soc., (2012), 134, 566.

Discovery of linear receptors for multiple dihydrogen phosphate ions using dynamic combinatorial chemistry, J. Am. Chem. Soc., (2011), 133, 3804.

Formation pathways of Donor-Acceptor catenanes in aqueous dynamic combinatorial libraries, J. Am. Chem. Soc., (2011), 133, 3198.

Solid-state dynamic combinatorial chemistry, Chem. Sci., (2011), 2, 696.

An unexpected receptor for C70, Angew. Chemie Intl. Edn., (2008), 47, 2689.


Guest-induced transformation of a porphyrin-edged Fe<sup>II</sup><inf>4</inf>L<inf>6</inf> capsule into a Cu<sup>I</sup>Fe<sup>II</sup><inf>2</inf>L<inf>4</inf> fullerene receptor
DM Wood, W Meng, TK Ronson, AR Stefankiewicz, JKM Sanders, JR Nitschke
– Angew Chem Int Ed Engl
Direct Observation of Intermediates in a Thermodynamically Controlled Solid-State Dynamic Covalent Reaction
AM Belenguer, GI Lampronti, DJ Wales, JKM Sanders
– Journal of the American Chemical Society
Homochiral and meso figure eight knots and a solomon link
N Ponnuswamy, FBL Cougnon, GD Pantoş, JKM Sanders
– Journal of the American Chemical Society
Disulfide exchange: exposing supramolecular reactivity through dynamic covalent chemistry
SP Black, JKM Sanders, AR Stefankiewicz
– Chemical Society reviews
Dynamic combinatorial chemistry at the phospholipid bilayer interface
FM Mansfeld, HY Au-Yeung, JKM Sanders, S Otto
– Journal of Systems Chemistry
Editorial: how can change be achieved?- energy saving in cambridge.
JKM Sanders
– Angew Chem Int Ed Engl
Generation of a Dynamic System of Three-Dimensional Tetrahedral Polycatenanes
SP Black, AR Stefankiewicz, MMJ Smulders, D Sattler, CA Schalley, JR Nitschke, JKM Sanders
– Angew Chem Int Ed Engl
Diverse topologies in dynamic combinatorial libraries from tri- and mono-thiols in water: sensitivity to weak supramolecular interactions.
AR Stefankiewicz, JKM Sanders
– Chemical communications (Cambridge, England)
Evolution of Dynamic Combinatorial Chemistry
FBL Cougnon, JKM Sanders
– Accounts of Chemical Research
Structural parameters governing the dynamic combinatorial synthesis of catenanes in water
FBL Cougnon, N Ponnuswamy, NA Jenkins, GD Pantoş, JKM Sanders
– Journal of the American Chemical Society
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01223 336411

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