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Yusuf Hamied Department of Chemistry

 

We are interested in molecular recognition, aiming to uncover and exploit the rules governing non-covalent interactions. Hydrophobic, π–π, donor–acceptor, metal– ligand and hydrogen bonding interactions are used to create new supramolecular systems that expand our understanding of molecular behaviour and may have useful recognition, catalytic or photophysical properties. In particular in the past few years we have developed the concept of dynamic combinatorial chemistry as a new approach for discovering entirely unexpected structures and assemblies. Over the years our building blocks have included peptides, metalloporphyrins, steroids and simple aromatics, and our products have included macrocycles, rotaxanes, catenanes, molecular knots and supramolecular nanotubes. Very recently, while investigating dynamic chemistry in the solid state using ball mill grinding, we have discovered solvent and surface effects on polymorph stability in nanocrystals

Please note that I am not taking any new students or postdocs into my research group.

 

 

 

Selected Publications

 

Evolution of dynamic combinatorial chemistry, Accounts Chem. Res., (2012), 45, 2211.

Discovery of an organic trefoil knot, Science, (2012), 338, 783.

Templated dynamic synthesis of a [3]Catenane, Angew. Chemie Intl. Edn., (2012), 51, 1443.

Thermodynamics of supramolecular naphthalenediimide nanotubes, J. Am. Chem. Soc., (2012), 134, 566.

Discovery of linear receptors for multiple dihydrogen phosphate ions using dynamic combinatorial chemistry, J. Am. Chem. Soc., (2011), 133, 3804.

Formation pathways of Donor-Acceptor catenanes in aqueous dynamic combinatorial libraries, J. Am. Chem. Soc., (2011), 133, 3198.

Solid-state dynamic combinatorial chemistry, Chem. Sci., (2011), 2, 696.

An unexpected receptor for C70, Angew. Chemie Intl. Edn., (2008), 47, 2689.

Publications

Solvation Rules: Aromatic Interactions Outcompete Cation-π Interactions in Synthetic Host-Guest Complexes in Water
G Tobajas-Curiel, Q Sun, JKM Sanders, P Ballester, CA Hunter
– Chem Commun (Camb)
(2023)
59,
14146
Solvation rules: aromatic interactions outcompete cation–π interactions in synthetic host–guest complexes in water
G Tobajas-Curiel, Q Sun, JKM Sanders, P Ballester, CA Hunter
– Chemical Communications
(2023)
59,
14146
Aromatic interactions with heterocycles in water
G Tobajas-Curiel, Q Sun, JKM Sanders, P Ballester, CA Hunter
– Chem Sci
(2023)
14,
11131
Substituent effects on aromatic interactions in water.
G Tobajas-Curiel, Q Sun, JKM Sanders, P Ballester, CA Hunter
– Chemical Science
(2023)
14,
6226
Substituent effects on aromatic interactions in water †
G Tobajas-Curiel, Q Sun, JKM Sanders, P Ballester, CA Hunter
– Chemical Science
(2023)
14,
6226
Aromatic interactions with heterocycles in water
G Tobajas-Curiel, Q Sun, JKM Sanders, P Ballester, CA Hunter
– Chemical Science
(2023)
14,
11131
Quantitative reversible one pot interconversion of three crystalline polymorphs by ball mill grinding
AM Belenguer, GI Lampronti, AAL Michalchuk, F Emmerling, JKM Sanders
– CrystEngComm
(2022)
24,
4256
Using Solid Catalysts in Disulfide-Based Dynamic Combinatorial Solution- and Mechanochemistry.
AM Belenguer, AAL Michalchuk, GI Lampronti, JKM Sanders
– ChemSusChem
(2021)
15,
e202102416
What has Royal Society Open Science achieved in its first few years?
JKM Sanders
– R Soc Open Sci
(2021)
8,
211838
Changing the game of time resolved X-ray diffraction on the mechanochemistry playground by downsizing
GI Lampronti, AAL Michalchuk, PP Mazzeo, AM Belenguer, JKM Sanders, A Bacchi, F Emmerling
– Nature Communications
(2021)
12,
6134
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Research Group

Research Interest Groups

Telephone number

01223 336411

Email address

jkms@cam.ac.uk