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Yusuf Hamied Department of Chemistry


We are interested in molecular recognition, aiming to uncover and exploit the rules governing non-covalent interactions. Hydrophobic, π–π, donor–acceptor, metal– ligand and hydrogen bonding interactions are used to create new supramolecular systems that expand our understanding of molecular behaviour and may have useful recognition, catalytic or photophysical properties. In particular in the past few years we have developed the concept of dynamic combinatorial chemistry as a new approach for discovering entirely unexpected structures and assemblies. Over the years our building blocks have included peptides, metalloporphyrins, steroids and simple aromatics, and our products have included macrocycles, rotaxanes, catenanes, molecular knots and supramolecular nanotubes. Very recently, while investigating dynamic chemistry in the solid state using ball mill grinding, we have discovered solvent and surface effects on polymorph stability in nanocrystals

Please note that I am not taking any new students or postdocs into my research group.




Selected Publications


Evolution of dynamic combinatorial chemistry, Accounts Chem. Res., (2012), 45, 2211.

Discovery of an organic trefoil knot, Science, (2012), 338, 783.

Templated dynamic synthesis of a [3]Catenane, Angew. Chemie Intl. Edn., (2012), 51, 1443.

Thermodynamics of supramolecular naphthalenediimide nanotubes, J. Am. Chem. Soc., (2012), 134, 566.

Discovery of linear receptors for multiple dihydrogen phosphate ions using dynamic combinatorial chemistry, J. Am. Chem. Soc., (2011), 133, 3804.

Formation pathways of Donor-Acceptor catenanes in aqueous dynamic combinatorial libraries, J. Am. Chem. Soc., (2011), 133, 3198.

Solid-state dynamic combinatorial chemistry, Chem. Sci., (2011), 2, 696.

An unexpected receptor for C70, Angew. Chemie Intl. Edn., (2008), 47, 2689.


Changing the game of time resolved X-ray diffraction on the mechanochemistry playground by downsizing.
GI Lampronti, AAL Michalchuk, PP Mazzeo, AM Belenguer, JKM Sanders, A Bacchi, F Emmerling
– Nat Commun
Implications of Thermodynamic Control: Dynamic Equilibrium Under Ball Mill Grinding Conditions
AM Belenguer, GI Lampronti, JKM Sanders
– Israel Journal of Chemistry
Reviewers in 2020
JKM Sanders
– R Soc Open Sci
Launching science, society and policy
A Smith, JKM Sanders
– Royal Society open science
Reviewers in 2019
JK Sanders
– R Soc Open Sci
Editorial 2020: Changing publishing and academic culture.
JKM Sanders
– Royal Society Open Science
Understanding the unexpected effect of frequency on the kinetics of a covalent reaction under ball-milling conditions.
AM Belenguer, AAL Michalchuk, GI Lampronti, JKM Sanders
– Beilstein J Org Chem
Reviewers in 2018.
JKM Sanders
– R Soc Open Sci
On the prevalence of smooth polymorphs at the nanoscale: implications for pharmaceuticals
AM Belenguer, AJ Cruz-Cabeza, GI Lampronti, JKM Sanders
– CrystEngComm
Understanding the Influence of Surface Solvation and Structure on Polymorph Stability: A Combined Mechanochemical and Theoretical Approach.
AM Belenguer, GI Lampronti, N De Mitri, M Driver, CA Hunter, JKM Sanders
– Journal of the American Chemical Society
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Research Group

Research Interest Groups

Telephone number

01223 336411

Email address