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Department of Chemistry

 

 


Sidney Sussex College Research Fellow


 


Education


​2016 - PhD in Biophysical Chemistry, University of Cambridge


2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge


2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology


 


Research Interests


Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening


 


Selected Publications


 

Publications

Kinetic Analysis of Amyloid Formation.
G Meisl, TCT Michaels, S Linse, TPJ Knowles
– Methods Mol Biol
(2018)
1779,
181
Absolute Quantification of Amyloid Propagons by Digital Microfluidics
M Pfammatter, M Andreasen, G Meisl, CG Taylor, J Adamcik, S Bolisetty, A Sánchez-Ferrer, D Klenerman, CM Dobson, R Mezzenga, TPJ Knowles, A Aguzzi, S Hornemann
– Anal Chem
(2017)
89,
12306
Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.
A Munke, J Persson, T Weiffert, E De Genst, G Meisl, P Arosio, A Carnerup, CM Dobson, M Vendruscolo, TPJ Knowles, S Linse
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
6444
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limbocker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E1009
Scaling behaviour and rate-determining steps in filamentous self-assembly.
G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– Chemical Science
(2017)
8,
7087
Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants.
G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles
– Chemical Science
(2017)
8,
4352
Physical determinants of the self-replication of protein fibrils
A Šaric, AK Buell, G Meisl, TCT Michaels, CM Dobson, S Linse, TPJ Knowles, D Frenkel
– Nature Physics
(2016)
12,
874
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.
P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, AK Buell, C Galvagnion
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
113,
10328
An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation.
EV Yates, G Meisl, TPJ Knowles, CM Dobson
– J Phys Chem B
(2016)
120,
2087
Molecular mechanisms of protein aggregation from global fitting of kinetic models.
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
– Nature protocols
(2016)
11,
252
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Research Group

Telephone number

01223 763842
01223 763845 (shared)

Email address

gm373@cam.ac.uk