Research Associate
Education
2016 - PhD in Biophysical Chemistry, University of Cambridge
2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge
2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology
Research Interests
Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening
Selected Publications
- G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles and D Klenerman "In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease", Science Advances 7, eabh1448 (2021)
- G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, TCT Michaels, D Heinzer, M Avar, SIA Cohen, S Horneman, A Aguzzi, CM Dobson, CJ Sigurdson and TPJ Knowles “Scaling analysis reveals the mechanism and rates of prion replication in vivo”, Nature Structural and Molecular Biology 28, 365 (2021)
- G Meisl, TPJ Knowles, D Klenerman “The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.” Current Opinion in Neurobiology 61, 58 (2020)
- G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson and TPJ Knowles, "Scaling behaviour and rate-determining steps in filamentous self-assembly", Chemcial Science (2017)
- G Meisl, X Yang, CM Dobson, S Linse and TPJ Knowles, "Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants", Chemical Science 8, 4352 (2017)
- G Meisl, JB Kirkegaard, P Arosio, M Vendruscolo, CM Dobson, S Linse and TPJ Knowles, “Molecular mechanisms of protein aggregation from global fitting of kinetic models”, Nature Protocols 11, 252 (2016)
- G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse and TPJ Knowles, "Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.", Proceedings of the National Academy of Sciences, 111, 9384 (2014)
Publications
Perphenazine–Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid
– ACS Chem Neurosci
(2022)
14,
87
(doi: 10.1021/acschemneuro.2c00498)
Uncovering the universality of self-replication in protein aggregation and its link to disease.
– Science Advances
(2022)
8,
eabn6831
(doi: 10.1126/sciadv.abn6831)
A conformational switch controlling the toxicity of the prion protein
– Nature Structural & Molecular Biology
(2022)
29,
831
(doi: 10.1038/s41594-022-00814-7)
Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants
– iScience
(2022)
25,
104766
(doi: 10.1016/j.isci.2022.104766)
Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales: From the Test Tube to Neurodegenerative Disease
– Frontiers in Neuroscience
(2022)
16,
909861
(doi: 10.3389/fnins.2022.909861)
Uncovering the universality of self-replication in protein aggregation and its link to disease
(2022)
(doi: 10.1101/2022.06.08.495339)
Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2.
– ACS infectious diseases
(2022)
8,
790
(doi: 10.1021/acsinfecdis.1c00486)
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity
– Molecules
(2022)
27,
1293
(doi: 10.3390/molecules27041293)
The pathological G51D mutation in alpha-synuclein oligomers confers distinct structural attributes and cellular toxicity
– Molecules (Basel, Switzerland)
(2022)
27,
1293
(doi: 10.3390/molecules27041293)
The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization.
– Communications Biology
(2022)
5,
123
(doi: 10.1038/s42003-022-03059-8)
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