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Yusuf Hamied Department of Chemistry



Ramon Jenkins Research Fellow, Sidney Sussex College



​2016 - PhD in Biophysical Chemistry, University of Cambridge

2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge

2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology


Research Interests

Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening


Selected Publications



The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces
T Scheidt, JA Carozza, CC Kolbe, FA Aprile, O Tkachenko, MMJ Bellaiche, G Meisl, QAE Peter, TW Herling, S Ness, M Castellana-Cruz, JLP Benesch, M Vendruscolo, CM Dobson, P Arosio, TPJ Knowles
– Proceedings of the National Academy of Sciences
Alpha Synuclein only Forms Fibrils In Vitro when Larger than its Critical Size of 70 Monomers.
SE Sanchez, DR Whiten, G Meisl, FS Ruggeri, E Hidari, D Klenerman
– ChemBioChem: a European journal of chemical biology
Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape
S Fiedler, V Denninger, A Morgunov, A Ilsley, R Worth, G Meisl, C Xu, M Piziorska, F Ricci, A Malik, S Devenish, M Schneider, V Kosmoliaptsis, A Aguzzi, A Iwasaki, H Fiegler, T Knowles
Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2
V Denninger, C Xu, G Meisl, A Morgunov, S Fiedler, A Ilsley, M Emmenegger, A Malik, M Piziorska, M Schneider, S Devenish, V Kosmoliaptsis, A Aguzzi, H Fiegler, T Knowles
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-beta and alpha-Synuclein and Suppress the Toxicity of Their Oligomers
R Limbocker, R Staats, S Chia, FS Ruggeri, B Mannini, CK Xu, M Perni, R Cascella, A Bigi, LR Sasser, NR Block, AK Wright, RP Kreiser, ET Custy, G Meisl, S Errico, J Habchi, P Flagmeier, T Kartanas, JE Hollows, LT Nguyen, K LeForte, D Barbut, JR Kumita, C Cecchi, M Zasloff, TPJ Knowles, CM Dobson, F Chiti, M Vendruscolo
– Frontiers in Neuroscience
Super-resolution imaging reveals alpha-synuclein seeded aggregation in SH-SY5Y cells
JC Sang, E Hidari, G Meisl, RT Ranasinghe, MG Spillantini, D Klenerman
– Commun Biol
Pulsed Hydrogen-Deuterium Exchange Reveals Altered Structures and Mechanisms in the Aggregation of Familial Alzheimer's Disease Mutants
E Illes-Toth, G Meisl, DL Rempel, TPJ Knowles, ML Gross
– ACS Chemical Neuroscience
Antibody Affinity Governs the Inhibition of SARS-CoV‑2 Spike/ACE2 Binding in Patient Serum
S Fiedler, MA Piziorska, V Denninger, AS Morgunov, A Ilsley, AY Malik, MM Schneider, SRA Devenish, G Meisl, V Kosmoliaptsis, A Aguzzi, H Fiegler, TPJ Knowles
– ACS Infectious Diseases
Tau AD fragment aggregates proliferate through autocatalytic secondary nucleation
DR Camargo, E Sileikis, S Chia, E Axell, K Bernfur, R Cataldi, S Cohen, G Meisl, J Habchi, T Knowles, M Vendruscolo, S Linse
The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases.
TB Thompson, G Meisl, TPJ Knowles, A Goriely
– J Chem Phys
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Research Group

Telephone number

01223 763842
01223 763845 (shared)

Email address