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Department of Chemistry

 

 

Ramon Jenkins Research Fellow, Sidney Sussex College

 

Education

​2016 - PhD in Biophysical Chemistry, University of Cambridge

2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge

2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology

 

Research Interests

Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening

 

Selected Publications

 

Publications

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation
G Meisl, TPJ Knowles, D Klenerman
– Current Opinion in Neurobiology
(2020)
61,
58
Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers
SA Ghadami, S Chia, FS Ruggeri, G Meisl, F Bemporad, J Habchi, R Cascella, CM Dobson, M Vendruscolo, TPJ Knowles, F Chiti
– Biomacromolecules
(2020)
acs.biomac.9b01475
The catalytic nature of protein aggregation.
AJ Dear, G Meisl, TCT Michaels, MR Zimmermann, S Linse, TPJ Knowles
– J Chem Phys
(2020)
152,
045101
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
T Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, A Dear, S Cohen, M Vendruscolo, C Dobson, S Linse, T Knowles
(2020)
alpha-Synuclein strains target distinct brain regions and cell types
A Lau, RWL So, HHC Lau, JC Sang, A Ruiz-Riquelme, SC Fleck, E Stuart, S Menon, NP Visanji, G Meisl, R Faidi, MM Marano, C Schmitt-Ulms, Z Wang, PE Fraser, A Tandon, BT Hyman, H Wille, M Ingelsson, D Klenerman, JC Watts
– Nat Neurosci
(2020)
23,
21
Trodusquemine enhances Aβ
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nat Commun
(2019)
10,
225
Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers.
Z Najarzadeh, H Mohammad-Beigi, J Nedergaard Pedersen, G Christiansen, TV Sønderby, SA Shojaosadati, D Morshedi, K Strømgaard, G Meisl, D Sutherland, J Skov Pedersen, DE Otzen
– Biomolecules
(2019)
9,
659
Autoantibodies against the prion protein in individuals with PRNP mutations
K Frontzek, MC Carta, M Losa, M Epskamp, G Meisl, A Anane, J-P Brandel, U Camenisch, J Castilla, S Haik, T Knowles, E Lindner, A Lutterotti, EV Minikel, I Roiter, J Safar, R Sanchez-Valle, D Zakova, S Hornemann, A Aguzzi
(2019)
Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid.
R Frankel, M Törnquist, G Meisl, O Hansson, U Andreasson, H Zetterberg, K Blennow, B Frohm, T Cedervall, TPJ Knowles, T Leiding, S Linse
– Commun Biol
(2019)
2,
365
Mechanism of Fibril and Soluble Oligomer Formation in Amyloid Beta and Hen Egg White Lysozyme Proteins
C Perez, T Miti, F Hasecke, G Meisl, W Hoyer, M Muschol, G Ullah
– The journal of physical chemistry. B
(2019)
123,
5678
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Research Group

Telephone number

01223 763845 (shared)
01223 763842

Email address

gm373@cam.ac.uk