Research Associate
Education
2016 - PhD in Biophysical Chemistry, University of Cambridge
2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge
2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology
Research Interests
Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening
Selected Publications
- G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles and D Klenerman "In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease", Science Advances 7, eabh1448 (2021)
- G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, TCT Michaels, D Heinzer, M Avar, SIA Cohen, S Horneman, A Aguzzi, CM Dobson, CJ Sigurdson and TPJ Knowles “Scaling analysis reveals the mechanism and rates of prion replication in vivo”, Nature Structural and Molecular Biology 28, 365 (2021)
- G Meisl, TPJ Knowles, D Klenerman “The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.” Current Opinion in Neurobiology 61, 58 (2020)
- G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson and TPJ Knowles, "Scaling behaviour and rate-determining steps in filamentous self-assembly", Chemcial Science (2017)
- G Meisl, X Yang, CM Dobson, S Linse and TPJ Knowles, "Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants", Chemical Science 8, 4352 (2017)
- G Meisl, JB Kirkegaard, P Arosio, M Vendruscolo, CM Dobson, S Linse and TPJ Knowles, “Molecular mechanisms of protein aggregation from global fitting of kinetic models”, Nature Protocols 11, 252 (2016)
- G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse and TPJ Knowles, "Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.", Proceedings of the National Academy of Sciences, 111, 9384 (2014)
Publications
Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies
(2025)
(doi: 10.1101/2025.02.05.636249)
Transforming an ATP-dependent enzyme into a dissipative, self-assembling system.
– Nature Chemical Biology
(2025)
1
(doi: 10.1038/s41589-024-01811-1)
Tau accumulation patterns in PSP constrain mechanisms and quantify cell-to-cell and cell-autonomous aggregation rates
(2024)
(doi: 10.1101/2024.12.14.24318991)
Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules
(2024)
(doi: 10.1101/2024.11.07.622437)
Serine phosphorylation mimics of Aβ form distinct, non-cross-seeding fibril morphs.
– Chemical Science
(2024)
15,
19142
(doi: 10.1039/d3sc06343g)
Surface effects on functional amyloid formation
– Nanoscale
(2024)
16,
16172
(doi: 10.1039/d4nr01496k)
α-Synuclein oligomers form by secondary nucleation.
– Nat Commun
(2024)
15,
7083
(doi: 10.1038/s41467-024-50692-4)
The Cystic Fibrosis Transmembrane Regulator Controls Tolerogenic Responses to Food Allergens in Mice and Humans
(2024)
(doi: 10.1101/2024.06.17.24309019)
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces
– ACS chemical neuroscience
(2024)
15,
2296
(doi: 10.1021/acschemneuro.4c00127)
Kinetic models reveal the interplay of protein production and aggregation
– Chemical science
(2024)
15,
8430
(doi: 10.1039/d4sc00088a)
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