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Yusuf Hamied Department of Chemistry

 

Our major research programme concerns the folding, stability and activity of proteins. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular biology and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, cell culture, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR (we have a 500, 600, 700 and an 800 MHz spectrometers) and x-ray protein crystallography.

Current major projects include: protein folding, misfolding and disease; drug discovery; and structure-activity relationships of proteins involved in cancer and disease.

Although now emeritus, I am still fully active in research with long term funding, including an MRC Programme Grant.

Publications

Downhill versus Barrier-Limited Folding of BBL 1: Energetic and Structural Perturbation Effects upon Protonation of a Histidine of Unusually Low pKa
E Arbely, TJ Rutherford, TD Sharpe, N Ferguson, AR Fersht
– Journal of Molecular Biology
(2009)
387,
986
Corrigendum to “Conservation of Transition State Structure in Fast Folding Peripheral Subunit-Binding Domains” [J. Mol. Biol. 383 (2008) 224–237]
TD Sharpe, N Ferguson, CM Johnson, AR Fersht
– Journal of Molecular Biology
(2009)
387,
519
Conservation of Transition State Structure in Fast Folding Peripheral Subunit-Binding Domains (vol 383, pg 224, 2008)
TD Sharpe, N Ferguson, CM Johnson, AR Fersht
– Journal of Molecular Biology
(2009)
387,
519
Time-Resolved Fluorescence Resonance Energy Transfer Study Shows a Compact Denatured State of the B Domain of Protein A
F Huang, E Lerner, S Sato, D Amir, E Haas, AR Fersht
– Biochemistry
(2009)
48,
3468
Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers
J van Dieck, MR Fernandez-Fernandez, DB Veprintsev, AR Fersht
– Journal of Biological Chemistry
(2009)
284,
13804
Downhill versus Barrier-Limited Folding of BBL 3. Heterogeneity of the Native State of the BBL Peripheral Subunit Binding Domain and Its Implications for Folding Mechanisms
G Settanni, AR Fersht
– J Mol Biol
(2009)
387,
993
Solution structure of the U11-48K CHHC zinc-finger domain that specifically binds the 5' splice site of U12-type introns.
H Tidow, A Andreeva, TJ Rutherford, AR Fersht
– Structure
(2009)
17,
294
Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation.
S Burge, DP Teufel, FM Townsley, SMV Freund, M Bycroft, AR Fersht
– Proc Natl Acad Sci U S A
(2009)
106,
3142
Protein folding and binding: moving into unchartered territory.
V Daggett, AR Fersht
– Current Opinion in Structural Biology
(2009)
19,
1
Single-molecule Studies Of p53 Sliding Along DNA
A Tafvizi, JS Leith, F Huang, AR Fersht, LA Mirny, AM van Oijen
– Biophysical Journal
(2009)
96,
417a
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