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Yusuf Hamied Department of Chemistry

 

Professor Sir Alan Fersht FRS

Our major research programme concerns the folding, stability and activity of proteins. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular biology and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, cell culture, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR (we have a 500, 600, 700 and an 800 MHz spectrometers) and x-ray protein crystallography.

Current major projects include: protein folding, misfolding and disease; drug discovery; and structure-activity relationships of proteins involved in cancer and disease.

Although now emeritus, I am still fully active in research with long term funding, including an MRC Programme Grant.

Publications

Sequence-Dependent Kinetics of One-Dimensional Diffusion of p53 on DNA
JS Leith, A Tafvizi, F Huang, AR Fersht, LA Mirny, AM van Oijen
– Biophysical Journal
(2009)
96,
416A
(doi: 10.1016/j.bpj.2008.12.2125)
Human full-length Securin is a natively unfolded protein.
N Sánchez-Puig, DB Veprintsev, AR Fersht
– Protein Science
(2009)
14,
1410
(doi: 10.1110/ps.051368005)
Physical-organic molecular biology: pathway and stability of protein folding
AR FERSHT, A MATOUSCHEK, M BYCROFT, JT KELLIS, L SERRANO
– Pure and Applied Chemistry
(2009)
63,
187
(doi: 10.1351/pac199163020187)
Chemical basis of biological specificity
AR FERSHT
– Pure and Applied Chemistry
(2009)
54,
1819
(doi: 10.1351/pac198254101819)
Design of highly stable functional GroEL minichaperones.
Q Wang, AM Buckle, NW Foster, CM Johnson, AR Fersht
– Protein Sci
(2008)
8,
2186
(doi: 10.1110/ps.8.10.2186)
The effects of disulfide bonds on the denatured state of barnase
J Clarke, AM Hounslow, CJ Bond, AR Fersht, V Daggett
– Protein Sci
(2008)
9,
2394
(doi: 10.1110/ps.9.12.2394)
Real-time NMR studies on a transient folding intermediate of barstar
TR Killick, SM Freund, AR Fersht
– Protein Science
(2008)
8,
1286
(doi: 10.1110/ps.8.6.1286)
Folding of barstar C40A/C82A/P27A and catalysis of the peptidyl-prolyl cis/trans isomerization by human cytosolic cyclophilin (Cyp18).
R Golbik, G Fischer, AR Fersht
– Protein Science
(2008)
8,
1505
(doi: 10.1110/ps.8.7.1505)
Downhill versus barrier-limited folding of BBL 2: mechanistic insights from kinetics of folding monitored by independent tryptophan probes.
H Neuweiler, TD Sharpe, CM Johnson, DP Teufel, N Ferguson, AR Fersht
– Journal of molecular biology
(2008)
387,
975
(doi: 10.1016/j.jmb.2008.12.056)
Downhill versus Barrier-Limited Folding of BBL 1: Energetic and Structural Perturbation Effects upon Protonation of a Histidine of Unusually Low pK a
E Arbely, TJ Rutherford, TD Sharpe, N Ferguson, AR Fersht
– J Mol Biol
(2008)
387,
986
(doi: 10.1016/j.jmb.2008.12.055)
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