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Yusuf Hamied Department of Chemistry

 

Our major research programme concerns the folding, stability and activity of proteins. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular biology and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, cell culture, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR (we have a 500, 600, 700 and an 800 MHz spectrometers) and x-ray protein crystallography.

Current major projects include: protein folding, misfolding and disease; drug discovery; and structure-activity relationships of proteins involved in cancer and disease.

Although now emeritus, I am still fully active in research with long term funding, including an MRC Programme Grant.

Publications

Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere.
R Wilcken, MO Zimmermann, MR Bauer, TJ Rutherford, AR Fersht, AC Joerger, FM Boeckler
– ACS Chemical Biology
(2015)
10,
2725
Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation.
A Nasedkin, M Marcellini, TL Religa, SM Freund, A Menzel, AR Fersht, P Jemth, D van der Spoel, J Davidsson
– PLoS One
(2015)
10,
e0125662
Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding.
G Wang, AR Fersht
– Proceedings of the National Academy of Sciences
(2015)
112,
2443
Mechanism of initiation of aggregation of p53 revealed by Φ-value analysis.
G Wang, AR Fersht
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
2437
Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 Nobel Laureates in Chemistry
AR Fersht
– Proc Natl Acad Sci U S A
(2013)
110,
19656
MDMX contains an autoinhibitory sequence element
M Bista, M Petrovich, AR Fersht
– Proceedings of the National Academy of Sciences of the United States of America
(2013)
110,
17814
Small molecule induced reactivation of mutant p53 in cancer cells
X Liu, R Wilcken, AC Joerger, IS Chuckowree, J Amin, J Spencer, AR Fersht
– Nucleic Acids Research
(2013)
41,
6034
Reply to Campos and Muñoz: Why phosphate is a bad buffer for guanidinium chloride titrations
AR Fersht, M Petrovich
– Proceedings of the National Academy of Sciences of the United States of America
(2013)
110,
E1244
Denaturation (Proteins)
AR Fersht
(2013)
302
Don’t waste good methods on bad buffers and ambiguous data
F Huang, CM Johnson, M Petrovich, AR Fersht
– Proc Natl Acad Sci U S A
(2013)
110,
e331
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