skip to content

Yusuf Hamied Department of Chemistry

 
Portrait of arf25

Our major research programme concerns the folding, stability and activity of proteins. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular biology and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, cell culture, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR (we have a 500, 600, 700 and an 800 MHz spectrometers) and x-ray protein crystallography.

Current major projects include: protein folding, misfolding and disease; drug discovery; and structure-activity relationships of proteins involved in cancer and disease.

Although now emeritus, I am still fully active in research with long term funding, including an MRC Programme Grant.

Publications

Mechanism of initiation of aggregation of p53 revealed by Φ-value analysis.
G Wang, AR Fersht
– Proc Natl Acad Sci U S A
(2015)
112,
2437
Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 Nobel Laureates in Chemistry
AR Fersht
– Proc Natl Acad Sci U S A
(2013)
110,
19656
MDMX contains an autoinhibitory sequence element.
M Bista, M Petrovich, AR Fersht
– Proceedings of the National Academy of Sciences
(2013)
110,
17814
Small molecule induced reactivation of mutant p53 in cancer cells
X Liu, R Wilcken, AC Joerger, IS Chuckowree, J Amin, J Spencer, AR Fersht
– Nucleic Acids Research
(2013)
41,
6034
HEFLibs: Chemical probes for detecting halogen bonding in fragment-based lead discovery
R Wilcken, AC Joerger, AR Fersht, FM Boeckler
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245,
Reply to Campos and Muñoz: Why phosphate is a bad buffer for guanidinium chloride titrations
AR Fersht, M Petrovich
– Proc Natl Acad Sci U S A
(2013)
110,
e1244
Denaturation (Proteins)
AR Fersht
(2013)
302
Don't waste good methods on bad buffers and ambiguous data
F Huang, CM Johnson, M Petrovich, AR Fersht
– Proceedings of the National Academy of Sciences of the United States of America
(2013)
110,
e331
Evaluating Drosophila p53 as a model system for studying cancer mutations
G Herzog, AC Joerger, MD Shmueli, AR Fersht, E Gazit, D Segal
– J Biol Chem
(2012)
287,
44330
Combining simulation and experiment to map protein folding
AL Jonsson, AR Fersht, V Daggett
(2012)
3,
1
  • <
  • 3 of 66
  • >