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Yusuf Hamied Department of Chemistry

 

Professor Sir Alan Fersht FRS

Our major research programme concerns the folding, stability and activity of proteins. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular biology and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, cell culture, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR (we have a 500, 600, 700 and an 800 MHz spectrometers) and x-ray protein crystallography.

Current major projects include: protein folding, misfolding and disease; drug discovery; and structure-activity relationships of proteins involved in cancer and disease.

Although now emeritus, I am still fully active in research with long term funding, including an MRC Programme Grant.

Publications

Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere.
R Wilcken, MO Zimmermann, MR Bauer, TJ Rutherford, AR Fersht, AC Joerger, FM Boeckler
– ACS Chem Biol
(2015)
10,
2725
(doi: 10.1021/acschembio.5b00515)
Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation
A Nasedkin, M Marcellini, TL Religa, SM Freund, A Menzel, AR Fersht, P Jemth, D van der Spoel, J Davidsson
– PLoS One
(2015)
10,
e0125662
(doi: 10.1371/journal.pone.0125662)
Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding.
G Wang, AR Fersht
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
2443
(doi: 10.1073/pnas.1500262112)
Mechanism of initiation of aggregation of p53 revealed by Φ-value analysis.
G Wang, AR Fersht
– Proceedings of the National Academy of Sciences
(2015)
112,
2437
(doi: 10.1073/pnas.1500243112)
Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 Nobel Laureates in Chemistry
AR Fersht
– Proc Natl Acad Sci U S A
(2013)
110,
19656
(doi: 10.1073/pnas.1320569110)
MDMX contains an autoinhibitory sequence element.
M Bista, M Petrovich, AR Fersht
– Proceedings of the National Academy of Sciences
(2013)
110,
17814
(doi: 10.1073/pnas.1317398110)
Small molecule induced reactivation of mutant p53 in cancer cells.
X Liu, R Wilcken, AC Joerger, IS Chuckowree, J Amin, J Spencer, AR Fersht
– Nucleic Acids Research
(2013)
41,
6034
(doi: 10.1093/nar/gkt305)
Reply to Campos and Muñoz: Why phosphate is a bad buffer for guanidinium chloride titrations
AR Fersht, M Petrovich
– Proc Natl Acad Sci U S A
(2013)
110,
E1244
(doi: 10.1073/pnas.1303286110)
Denaturation (Proteins)
AR Fersht
(2013)
302
(doi: 10.1016/B978-0-12-374984-0.00393-4)
Don't waste good methods on bad buffers and ambiguous data.
F Huang, CM Johnson, M Petrovich, AR Fersht
– Proc Natl Acad Sci U S A
(2013)
110,
e331
(doi: 10.1073/pnas.1217840110)
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