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Yusuf Hamied Department of Chemistry

Portrait of arf25

Our major research programme concerns the folding, stability and activity of proteins. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular biology and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, cell culture, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR (we have a 500, 600, 700 and an 800 MHz spectrometers) and x-ray protein crystallography.

Current major projects include: protein folding, misfolding and disease; drug discovery; and structure-activity relationships of proteins involved in cancer and disease.

Although now emeritus, I am still fully active in research with long term funding, including an MRC Programme Grant.


Multisite aggregation of p53 and implications for drug rescue.
G Wang, AR Fersht
– Proceedings of the National Academy of Sciences of the United States of America
Design of a molecular support for cryo-EM structure determination.
TG Martin, TAM Bharat, AC Joerger, X-C Bai, F Praetorius, AR Fersht, H Dietz, SHW Scheres
– Proc Natl Acad Sci U S A
2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells
MR Bauer, AC Joerger, AR Fersht
– Proceedings of the National Academy of Sciences
An in silico algorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein
D Bromley, MR Bauer, AR Fersht, V Daggett
– Protein Engineering, Design and Selection
Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs
MR Bauer, RN Jones, MGJ Baud, R Wilcken, FM Boeckler, AR Fersht, AC Joerger, J Spencer
– ACS chemical biology
The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches
AC Joerger, AR Fersht
– Annual review of biochemistry
Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.
AC Joerger, MR Bauer, R Wilcken, MGJ Baud, H Harbrecht, TE Exner, FM Boeckler, J Spencer, AR Fersht
– Structure
Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere
R Wilcken, MO Zimmermann, MR Bauer, TJ Rutherford, AR Fersht, AC Joerger, FM Boeckler
– ACS Chem Biol
Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation
A Nasedkin, M Marcellini, TL Religa, SM Freund, A Menzel, AR Fersht, P Jemth, D van der Spoel, J Davidsson
– PloS one
Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding.
G Wang, AR Fersht
– Proc Natl Acad Sci U S A
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