Dr Aleks Reinhardt | Yusuf Hamied Department of Chemistry

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Associate Professor

In my research, I use computer simulations and statistical mechanics to study the behaviour of molecular and colloidal systems. In particular, I am interested in phase transitions, nucleation and self-assembly, and how thermodynamic and kinetic factors affect and control them.

Dr Reinhardt discusses his research

Publications

Recombinase-Controlled Multiphase Condensates Accelerate Nucleic Acid Amplification and CRISPR-Based Diagnostics

A Homchan, M Patchsung, P Chantanakool, T Wongsatit, W Onchan, D Muengsaen, T Thaweeskulchai, M Tandean, T Sakpetch, S Suraritdechachai, K Aphicho, C Panchai, S Taiwan, N Horthongkham, T Sudyoadsuk, A Reinhardt, C Uttamapinant

– J Am Chem Soc

(2025)

147,

10088

(doi: 10.1021/jacs.4c11893)

Models and simulations of structural DNA nanotechnology reveal fundamental principles of self-assembly.

A Cumberworth, A Reinhardt

– Chemical Society Reviews

(2025)

54,

2344

(doi: 10.1039/d4cs01095g)

A streamlined molecular-dynamics workflow for computing solubilities of molecular and ionic crystals.

A Reinhardt, PY Chew, B Cheng

– The Journal of chemical physics

(2023)

159,

184110

(doi: 10.1063/5.0173341)

A streamlined molecular-dynamics workflow for computing solubilities of molecular and ionic crystals

A Reinhardt, PY Chew, B Cheng

(2023)

(doi: 10.48550/arxiv.2308.10886)

(link to publication)

Quantitative real-time in-cell imaging reveals heterogeneous clusters of proteins prior to condensation.

C Lan, J Kim, S Ulferts, F Aprile-Garcia, S Weyrauch, A Anandamurugan, R Grosse, R Sawarkar, A Reinhardt, T Hugel

– Nat Commun

(2023)

14,

4831

(doi: 10.1038/s41467-023-40540-2)

Aromatic and arginine content drives multiphasic condensation of protein-RNA mixtures

PY Chew, JA Joseph, R Collepardo-Guevara, A Reinhardt

– Biophysical Journal

(2023)

123,

1342

(doi: 10.1016/j.bpj.2023.06.024)

Aromatic and arginine content drives multiphasic condensation of protein–RNA mixtures

PY Chew, J Joseph, R Collepardo-Guevara, A Reinhardt

(2023)

(doi: 10.1101/2023.04.05.535720)

Physical determinants of multiphase organisation in multi-component protein/RNA condensates

PY Chew, JA Joseph, R Collepardo-Guevara, A Reinhardt

– Biophysical Journal

(2023)

122,

295a

(doi: 10.1016/j.bpj.2022.11.1672)

Thermodynamic origins of two-component multiphase condensates of proteins.

PY Chew, JA Joseph, R Collepardo-Guevara, A Reinhardt

– Chem Sci

(2023)

14,

2022.04.22.489187

(doi: 10.1039/d2sc05873a)

Signaling by cluster formation investigated with single-molecule fluorescence in living cells

S Weyrauch, C Lan, J Kim, S Ulferts, F Aprile-Garcia, A Anandamurugan, R Grosse, R Sawarkar, A Reinhardt, T Hugel

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2023)

52,

S213

(link to publication)