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Department of Chemistry

 

In my research, I normally use computer simulations and classical statistical mechanics to study the behaviour of molecular and colloidal systems. In particular, I am interested in nucleation and self-assembly – and combinations of the two – and how thermodynamic and kinetic factors affect and control them.

Self-assembly is a feature of microscopic systems: we would be quite justifiably surprised if, having shaken a box containing the loose component parts of a model aeroplane, we ended up with the fully assembled model. At the microscopic scale, however, such processes are not particularly surprising, and the spontaneous formation of complex virus capsids from simple protein building blocks, for instance, is a well-known and well-studied example of self-assembly. Artificially constructed materials that can spontaneously self-assemble into their target structures have also been studied extensively, and some amazing structures have been shown to form from simple building blocks: from closed clusters to complex crystals, liquid crystals and even quasicrystals.

However, there is a limit to how far simple building blocks can go in terms of the complexity of the self-assembled target structures that are possible to form in practice. It came as something of a shock to the self-assembly community when a recent experimental study [Science 338, 1117 (2012)] showed that potentially thousands of distinct DNA molecules can reproducibly self-assemble into complex, fully addressable, nearly error-free target structures. This was not meant to happen, as it had been well-established that having such a large number of distinct components would lead to self-poisoning and in turn a kinetic arrest of the growth of the target structure.

Much of my recent research has focussed on why structures like these can form successfully whilst other systems have failed to achieve anything even approaching such complexity. Following our simulation-based and theoretical work on model systems with the same type of connectivity and specificity as can be achieved with short DNA molecules, we have begun to understand how nucleation plays a very significant role in why such systems can self-assemble so successfully. I am currently continuing this work to try and understand how we can exploit the system's properties to guide the nucleation pathway and design the target structure in a rational way, as well as to learn more about the specific properties that govern this type of self-assembly that might be applied to different building blocks – such as colloids – in the future.

Publications

Microscopic analysis of thermo-orientation in systems of off-centre Lennard-Jones particles.
RL Jack, P Wirnsberger, A Reinhardt
– Journal of Chemical Physics
(2019)
150,
134501
Lattice models and Monte Carlo methods for simulating DNA origami self-assembly
A Cumberworth, A Reinhardt, D Frenkel
– The Journal of chemical physics
(2018)
149,
234905
Direct observation and rational design of nucleation behavior in addressable self-assembly
M Sajfutdinow, WM Jacobs, A Reinhardt, C Schneider, DM Smith
– Proc Natl Acad Sci U S A
(2018)
115,
E5877
Theoretical prediction of thermal polarisation
P Wirnsberger, C Dellago, D Frenkel, A Reinhardt
– Physical review letters
(2018)
120,
226001
Investigating the role of boundary bricks in DNA brick self-assembly
HK Wayment-Steele, D Frenkel, A Reinhardt
– Soft Matter
(2017)
13,
1670
Self-assembly of two-dimensional binary quasicrystals: A possible route to a DNA quasicrystal
A Reinhardt, JS Schreck, F Romano, JPK Doye
– Journal of physics. Condensed matter : an Institute of Physics journal
(2017)
29,
014006
DNA brick self-assembly with an off-lattice potential.
A Reinhardt, D Frenkel
– Soft matter
(2016)
12,
6253
Effects of co-ordination number on the nucleation behaviour in many-component self-assembly.
A Reinhardt, CP Ho, D Frenkel
– Faraday Discussions
(2015)
186,
215
Rational design of self-assembly pathways for complex multicomponent structures.
WM Jacobs, A Reinhardt, D Frenkel
– Proc Natl Acad Sci U S A
(2015)
112,
6313
Communication: Theoretical prediction of free-energy landscapes for complex self-assembly
WM Jacobs, A Reinhardt, D Frenkel
– The Journal of Chemical Physics
(2015)
142,
021101
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Research Interest Group

Telephone number

01223 336471 (shared)

Email address

ar732@cam.ac.uk