Publications by Professor Steve Ley CBE FRS FMedSci

Generation of Reactive Ketenes under Flow Conditions through Zinc-Mediated Dehalogenation

A Hafner, SV Ley

Synlett

(2015)

1470

(doi: 10.1055/s-0034-1380679)

Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439.

S-H Lau, A Galván, RR Merchant, C Battilocchio, JA Souto, MB Berry, SV Ley

Organic letters

(2015)

3218

(doi: 10.1021/acs.orglett.5b01307)

A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds

JS Poh, DN Tran, C Battilocchio, JM Hawkins, SV Ley

Angewandte Chemie - International Edition

(2015)

7920

(doi: 10.1002/anie.201501538)

Thiazole formation through a modified Gewald reaction

CJ Mallia, L Englert, GC Walter, IR Baxendale

Beilstein Journal of Organic Chemistry

(2015)

875

(doi: 10.3762/bjoc.11.98)

A Versatile Room‐Temperature Route to Di‐ and Trisubstituted Allenes Using Flow‐Generated Diazo Compounds

J Poh, DN Tran, C Battilocchio, JM Hawkins, SV Ley

Angewandte Chemie

(2015)

127

8031

(doi: 10.1002/ange.201501538)

A practical deca-gram scale ring expansion of (R)-(-)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1.

LDC Alves, AL Desiderá, KT de Oliveira, S Newton, SV Ley, TJ Brocksom

Org Biomol Chem

(2015)

7633

(doi: 10.1039/c5ob00525f)

Ethyl 2-hydroxy-2-phenyl-2-(thiazol-2-yl)acetate

C Mallia, L Englert, G Walter, I Baxendale

Molbank

(2015)

2015

m857

(doi: 10.3390/m857)

Large-Scale Synthesis of Crystalline 1,2,3,4,6,7-Hexa-O-acetyl-l-glycero-α-d-manno-heptopyranose.

C Stanetty, IR Baxendale

European J Org Chem

(2015)

2015

2718

(doi: 10.1002/ejoc.201500024)

Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines.

M Baumann, AM Rodriguez Garcia, IR Baxendale

Organic and Biomolecular Chemistry

(2015)

4231

(doi: 10.1039/c5ob00245a)

Syn-Ethyl 1-hydroxy-7-methoxy-2,3-dihydro-1H-pyrrolo[3,4-b]quinolone-3-carboxylate HCl Salt

M Baumann, I Baxendale

Molbank

(2015)

2015

m846

(doi: 10.3390/m846)

Back pressure regulation of slurry-forming reactions in continuous flow

BJ Deadman, DL Browne, IR Baxendale, SV Ley

Chemical Engineering and Technology

(2015)

259

(doi: 10.1002/ceat.201400445)

Chemistry in a changing world

SV Ley, RM Myers, DE Fitzpatrick

Actualite Chimique

(2015)

Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT_2C Receptor Agonists

G Rouquet, DE Moore, M Spain, DM Allwood, C Battilocchio, DC Blakemore, PV Fish, S Jenkinson, AS Jessiman, SV Ley, G McMurray, RI Storer

ACS Med Chem Lett

(2015)

329

(doi: 10.1021/ml500507v)

Flow Chemistry: Intelligent Processing of Gas-Liquid Transformations Using a Tube-in-Tube Reactor

M Brzozowski, M O'Brien, SV Ley, A Polyzos

Acc Chem Res

(2015)

349

(doi: 10.1021/ar500359m)

Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2

MS Christodoulou, F Calogero, M Baumann, AN García-Argáez, S Pieraccini, M Sironi, F Dapiaggi, R Bucci, G Broggini, S Gazzola, S Liekens, A Silvani, M Lahtela-Kakkonen, N Martinet, A Nonell-Canals, E Santamaría-Navarro, IR Baxendale, L Dalla Via, D Passarella

European journal of medicinal chemistry

(2015)

766

(doi: 10.1016/j.ejmech.2015.01.038)