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Yusuf Hamied Department of Chemistry

 

Publications by Professor Steven Lee

POLCAM: Instant molecular orientation microscopy for the life sciences
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, A Klymchenko, S Davis, E Paluch, D Klenerman, M Lew, K O’Holleran, S Lee
(2023)
(DOI: 10.1101/2023.02.07.527479)
resPAINT: Accelerating Volumetric Super-Resolution Localisation Microscopy by Active Control of Probe Emission
EW Sanders, AR Carr, E Bruggeman, M Körbel, SI Benaissa, RF Donat, AM Santos, J McColl, K O'Holleran, D Klenerman, SJ Davis, SF Lee, A Ponjavic
– Angewandte Chemie International Edition
(2022)
61,
e202206919
(DOI: 10.1002/anie.202206919)
resPAINT: Accelerating Volumetric Super‐Resolution Localisation Microscopy by Active Control of Probe Emission**
EW Sanders, AR Carr, E Bruggeman, M Körbel, SI Benaissa, RF Donat, AM Santos, J McColl, K O'Holleran, D Klenerman, SJ Davis, SF Lee, A Ponjavic
– Angew Chem Weinheim Bergstr Ger
(2022)
134,
e202206919
(DOI: 10.1002/ange.202206919)
Structure-specific amyloid precipitation in biofluids
M Rodrigues, P Bhattacharjee, A Brinkmalm, DT Do, CM Pearson, S De, A Ponjavic, JA Varela, K Kulenkampff, I Baudrexel, D Emin, FS Ruggeri, JE Lee, AR Carr, TPJ Knowles, H Zetterberg, TN Snaddon, S Gandhi, SF Lee, D Klenerman
– Nature Chemistry
(2022)
14,
1045
(DOI: 10.1038/s41557-022-00976-3)
Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses.
JX Meng, Y Zhang, D Saman, AM Haider, S De, JC Sang, K Brown, K Jiang, J Humphrey, L Julian, E Hidari, SF Lee, G Balmus, RA Floto, CE Bryant, JLP Benesch, Y Ye, D Klenerman
– Nature Communications
(2022)
13,
2692
(DOI: 10.1038/s41467-022-30461-x)
resPAINT: Accelerating volumetric super-resolution localisation microscopy by active control of probe emission
E Sanders, A Carr, E Bruggeman, M Koerbel, S Benaissa, R Donat, AM Santos, J McColl, K O’Holleran, D Klenerman, S Davis, S Lee, A Ponjavic
(2022)
(DOI: 10.1101/2022.04.14.488333)
ThX: a next generation probe for the early detection of amyloid aggregates
L-M Needham, J Weber, JA Varela, JWB Fyfe, DT Do, CK Xu, D Klenerman, CM Dobson, CA Hunter, SE Bohndiek, TN Snaddon, SF Lee
– Biophysical Journal
(2022)
121,
19a
(DOI: 10.1016/j.bpj.2021.11.2608)
Imaging T-cell activation: topography and features of early T-cell contacts
M Korbel, E Jenkins, JT McColl, C O'Brien-Ball, AH Lippert, AM Santos, SF Lee, SJ Davis, D Klenerman
– Biophysical Journal
(2022)
121,
150a
(DOI: 10.1016/j.bpj.2021.11.1976)
A Comparative Study of High-Contrast Fluorescence Lifetime Probes for Imaging Amyloid in Tissue.
F Gorka, CM Pearson, E Bulovaite, YP Zhang, A Handa, SGN Grant, TN Snaddon, LM Needham, SF Lee
– The Journal of Physical Chemistry B
(2021)
125,
13710
(DOI: 10.1021/acs.jpcb.1c07762)
Quantum Emitter Localization in Layer-Engineered Hexagonal Boron Nitride
JC Stewart, Y Fan, JSH Danial, A Goetz, AS Prasad, OJ Burton, JA Alexander-Webber, SF Lee, SM Skoff, V Babenko, S Hofmann
– ACS nano
(2021)
15,
13591
(DOI: 10.1021/acsnano.1c04467)
Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent inflammatory responses
D Klenerman, J Meng, Y Zhang, D Saman, S De, J Sang, K Jiang, J Humphrey, L Julian, E Hidari, A Floto, S Lee, C Bryant, J Benesch, Y Ye
(2021)
(DOI: 10.21203/rs.3.rs-374549/v1)
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation.
A Vilalta, Y Zhou, J Sevalle, JK Griffin, K Satoh, DH Allendorf, S De, M Puigdellívol, A Bruzas, MA Burguillos, RB Dodd, F Chen, Y Zhang, P Flagmeier, L-M Needham, M Enomoto, S Qamar, J Henderson, J Walter, PE Fraser, D Klenerman, SF Lee, P St George-Hyslop, GC Brown
– Journal of Biological Chemistry
(2021)
296,
100631
(DOI: 10.1016/j.jbc.2021.100631)
Single-molecule fluorescence detection of a tricyclic nucleoside analogue.
GN Samaan, MK Wyllie, JM Cizmic, L-M Needham, D Nobis, K Ngo, S Andersen, SW Magennis, SF Lee, BW Purse
– Chemical science
(2020)
12,
2623
(DOI: 10.1039/d0sc03903a)
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer’s R47H mutant does the opposite
A Vilalta, Y Zhou, J Sevalle, J Griffin, K Satoh, D Allendorf, S De, M Puigdellívol, A Bruzas, M Burguillos, R Dodd, F Chen, Y Zhang, P Flagmeier, L-M Needham, M Enomoto, S Qamar, J Henderson, J Walter, P Fraser, D Klenerman, S Lee, P St George-Hyslop, G Brown
(2020)
(DOI: 10.1101/2020.12.03.409995)
Amyloid precipitation in biofluids using a structure-specific chemical antibody
M Rodrigues, P Bhattacharjee, A Brinkmalm, D Do, C Pearson, S De, A Ponjavic, J Varela, F Ruggeri, I Baudrexel, J Lee, A Carr, K Kulenkampff, T Knowles, H Zetterberg, T Snaddon, S Gandhi, S Lee, D Klenerman
(2020)
(DOI: 10.21203/rs.3.rs-81521/v1)
vLUME: 3D virtual reality for single-molecule localization microscopy.
S Lee, A Handa, L-M Needham, A Carr, A Ponjavic, J McColl
– Nat Methods
(2020)
17,
1097
(DOI: 10.1038/s41592-020-0962-1)
A Comparative Photophysical Study of Structural Modifications of Thioflavin T-Inspired Fluorophores.
L-M Needham, J Weber, CM Pearson, DT Do, F Gorka, G Lyu, SE Bohndiek, TN Snaddon, SF Lee
– J Phys Chem Lett
(2020)
11,
8406
(DOI: 10.1021/acs.jpclett.0c01549)
Single molecule light field microscopy
RR Sims, SA Rehman, MO Lenz, SI Benaissa, E Bruggeman, A Clark, EW Sanders, A Ponjavic, L Muresan, SF Lee, K O’Holleran
– Optica
(2020)
7,
1065
(DOI: 10.1364/optica.397172)
Single-molecule visualization of DNA G-quadruplex formation in live cells.
M Di Antonio, A Ponjavic, A Radzevičius, RT Ranasinghe, M Catalano, X Zhang, J Shen, L-M Needham, SF Lee, D Klenerman, S Balasubramanian
– Nature Chemistry
(2020)
12,
832
(DOI: 10.1038/s41557-020-0506-4)
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
FA Aprile, P Sormanni, M Podpolny, S Chhangur, L-M Needham, FS Ruggeri, M Perni, R Limbocker, GT Heller, T Sneideris, T Scheidt, B Mannini, J Habchi, SF Lee, PC Salinas, TPJ Knowles, CM Dobson, M Vendruscolo
– Proc Natl Acad Sci U S A
(2020)
117,
13509
(DOI: 10.1073/pnas.1919464117)

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