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Yusuf Hamied Department of Chemistry

 

Publications by Professor Ian Paterson FRSE FRS

Conquering peaks and illuminating depths: developing stereocontrolled organic reactions to unlock nature's macrolide treasure trove
NYS Lam, TP Stockdale, MJ Anketell, I Paterson
– Chemical communications (Cambridge, England)
(2021)
57,
3171
(DOI: 10.1039/d1cc00442e)
The stereocontrolled total synthesis of polyketide natural products: a thirty-year journey
TP Stockdale, NYS Lam, MJ Anketell, I Paterson
– Bulletin of the Chemical Society of Japan
(2020)
94,
713
(DOI: 10.1246/bcsj.20200309)
Total synthesis of the actinoallolides and a designed photoaffinity probe for target identification.
MJ Anketell, TM Sharrock, I Paterson
– Organic & Biomolecular Chemistry
(2020)
18,
8109
(DOI: 10.1039/d0ob01831g)
Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A
IE Ndukwe, X Wang, NYS Lam, K Ermanis, KL Alexander, MJ Bertin, GE Martin, G Muir, I Paterson, R Britton, JM Goodman, EJN Helfrich, J Piel, WH Gerwick, RT Williamson
– Chemical communications (Cambridge, England)
(2020)
56,
7565
(DOI: 10.1039/d0cc03055d)
Stereocontrolled Synthesis as an Enabling Tool for the Configurational Assignment of Marine Polyketide Natural Products
NYS Lam, I Paterson
– European Journal of Organic Chemistry
(2020)
2020,
2310
(DOI: 10.1002/ejoc.201901243)
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents
TR Pettigrew, RJ Porter, SJ Walsh, MP Housden, NYS Lam, JS Carroll, JS Parker, DR Spring, I Paterson
– Chemical communications (Cambridge, England)
(2020)
56,
1529
(DOI: 10.1039/c9cc09050a)
A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti‐Trypanosomal Macrolides
MJ Anketell, TM Sharrock, I Paterson
– Angewandte Chemie
(2020)
132,
1588
(DOI: 10.1002/ange.201914042)
Towards the Total Synthesis of Hemicalide: Synthesis of the C27-C46 Region
TP Stockdale, BY Han, NYS Lam, JM Goodman, I Paterson
– MARINE DRUGS
(2020)
18,
A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti‐Trypanosomal Macrolides
MJ Anketell, TM Sharrock, I Paterson
– Angewandte Chemie (International ed. in English)
(2019)
59,
1572
(DOI: 10.1002/anie.201914042)
A counterintuitive stereochemical outcome from a chelation-controlled vinylmetal aldehyde addition leads to the configurational reassignment of phormidolide A.
NYS Lam, G Muir, VR Challa, R Britton, I Paterson
– Chemical communications (Cambridge, England)
(2019)
55,
9717
(DOI: 10.1039/c9cc05067a)
Synthesis-enabled stereochemical assignment of the C1-C28 region of hemicalide: A potent cytotoxic polyketide of marine sponge origin
N Lam, BY Han, C MacGregor, J Goodman, I Paterson
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
257,
Designed analogues of the aplyronines for next-generation antibody-drug conjugates
R Porter, T Pettigrew, I Paterson, D Spring, J Parker
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
257,
Toward the total synthesis of patellazole B: synthesis of an advanced C1–C25 fragment corresponding to the macrocyclic skeleton
AW Phillips, MJ Anketell, T Balan, NYS Lam, S Williams, I Paterson
– Org Biomol Chem
(2018)
16,
8286
(DOI: 10.1039/c8ob01621f)
A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine-site of tubulin
G Menchon, AE Prota, D Lucena-Agell, P Bucher, R Jansen, H Irschik, R Müller, I Paterson, JF Díaz, K-H Altmann, MO Steinmetz
– Nature Communications
(2018)
9,
2106
(DOI: 10.1038/s41467-018-04535-8)
A synthesis-enabled relative stereochemical assignment of the c1-C28 region of hemicalide
BY Han, NYS Lam, CI MacGregor, JM Goodman, I Paterson
– Chemical communications (Cambridge, England)
(2018)
54,
3247
(DOI: 10.1039/c8cc00933c)
Toward Aplyronine Payloads for Antibody-Drug Conjugates: Total Synthesis of Aplyronines A and D
N AnŽiček, S Williams, MP Housden, I Paterson
– Organic & Biomolecular Chemistry
(2018)
16,
1343
(DOI: 10.1039/c7ob03204h)
Challenges and discoveries in the total synthesis of complex polyketide natural products
I Paterson, NYS Lam
– The Journal of antibiotics
(2017)
71,
215
(DOI: 10.1038/ja.2017.111)
Induction of accelerated senescence by the microtubule-stabilizing agent peloruside A.
A Chan, C Gilfillan, N Templeton, I Paterson, PT Northcote, JH Miller
– Investigational New Drugs
(2017)
35,
706
(DOI: 10.1007/s10637-017-0493-5)
Structural Basis of Microtubule Stabilization by Discodermolide
AE Prota, K Bargsten, M Redondo-Horcajo, AB Smith, C-PH Yang, HM McDaid, I Paterson, SB Horwitz, J Fernando Díaz, MO Steinmetz
– Chembiochem
(2017)
18,
905
(DOI: 10.1002/cbic.201600696)
Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration
JJ Field, PT Northcote, I Paterson, K-H Altmann, JF Díaz, JH Miller
– International Journal of Molecular Sciences
(2017)
18,
971
(DOI: 10.3390/ijms18050971)

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