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Yusuf Hamied Department of Chemistry

 

Publications by Professor Gonçalo Bernardes

Spacer length shapes drug release and therapeutic efficacy of traceless disulfide-linked ADCs targeting the tumor neovasculature
M Steiner, I Hartmann, E Perrino, G Casi, S Brighton, I Jelesarov, GJL Bernardes, D Neri
– Chem. Sci.
(2013)
4,
297
(DOI: 10.1039/C2SC21107F)
Generation of Carbon Monoxide Releasing Molecules (CO-RMs) as Drug Candidates for the Treatment of Acute Liver Injury: Targeting of CO-RMs to the Liver
AR Marques, L Kromer, DJ Gallo, N Penacho, SS Rodrigues, JD Seixas, GJL Bernardes, PM Reis, SL Otterbein, RA Ruggieri, ASG Gonçalves, AML Gonçalves, MND Matos, I Bento, LE Otterbein, WA Blättler, CC Romão
– Organometallics
(2012)
31,
5810
(DOI: 10.1021/om300360c)
Fucose-specific conjugation of hydrazide derivatives to a vascular-targeting monoclonal antibody in IgG format
K Zuberbühler, G Casi, GJL Bernardes, D Neri
– Chemical communications (Cambridge, England)
(2012)
48,
7100
(DOI: 10.1039/c2cc32412a)
A novel carbon monoxide-releasing molecule fully protects mice from severe malaria
AC Pena, N Penacho, L Mancio-Silva, R Neres, JD Seixas, AC Fernandes, CC Romão, MM Mota, GJL Bernardes, A Pamplona
– Antimicrobial Agents and Chemotherapy
(2012)
56,
1281
(DOI: 10.1128/AAC.05571-11)
Developing drug molecules for therapy with carbon monoxide
CC Romão, WA Blättler, JD Seixas, GJL Bernardes
– Chem Soc Rev
(2012)
41,
3571
(DOI: 10.1039/c2cs15317c)
Building well-defined glycoproteins
GJL Bernardes, BG Davis
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2012)
243,
Chemical site-selective protein modification: Development of a traceless vascular targeting ADC for cancer therapy
GJL Bernardes, D Neri, BG Davis
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2012)
243,
Chemical site-selective radiolabelling of proteins using fluorosugars
O Boutureira, GJL Bernardes, BG Davis
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2012)
243,
Selenenylsulfide-linked homogeneous glycopeptides and glycoproteins: synthesis of human "hepatic Se metabolite A".
O Boutureira, GJL Bernardes, M Fernández-González, DC Anthony, BG Davis
– Angewandte Chemie (International ed. in English)
(2011)
51,
1432
(DOI: 10.1002/anie.201106658)
A Traceless Vascular-Targeting Antibody–Drug Conjugate for Cancer Therapy
GJL Bernardes, G Casi, S Trüssel, I Hartmann, K Schwager, J Scheuermann, D Neri
– Angewandte Chemie International Edition
(2011)
51,
941
(DOI: 10.1002/anie.201106527)
Direct radiolabelling of proteins at cysteine using [18F]-fluorosugars.
O Boutureira, GJL Bernardes, F D'Hooge, BG Davis
– Chem Commun (Camb)
(2011)
47,
10010
(DOI: 10.1039/c1cc13524d)
Methods for converting cysteine to dehydroalanine on peptides and proteins
JM Chalker, SB Gunnoo, O Boutureira, SC Gerstberger, M Fernández-González, GJL Bernardes, L Griffin, H Hailu, CJ Schofield, BG Davis
– Chemical Science
(2011)
2,
1666
(DOI: 10.1039/c1sc00185j)
Towards improved therapeutic CORMs: understanding the reactivity of CORM-3 with proteins.
T Santos-Silva, A Mukhopadhyay, JD Seixas, GJL Bernardes, CC Romão, MJ Romão
– Curr Med Chem
(2011)
18,
3361
(DOI: 10.2174/092986711796504583)
Site-Selective Traceless Staudinger Ligation for Glycoprotein Synthesis Reveals Scope and Limitations
GJL Bernardes, L Linderoth, KJ Doores, O Boutureira, BG Davis
– ChemBioChem
(2011)
12,
1383
(DOI: 10.1002/cbic.201100125)
A “Tag-and-Modify” Approach to Site-Selective Protein Modification
JM Chalker, GJL Bernardes, BG Davis
– Accounts of Chemical Research
(2011)
44,
730
(DOI: 10.1021/ar200056q)
A coordinated synthesis and conjugation strategy for the preparation of homogeneous glycoconjugate vaccine candidates.
EJ Grayson, GJL Bernardes, JM Chalker, O Boutureira, JR Koeppe, BG Davis
– Angewandte Chemie International Edition
(2011)
50,
4127
(DOI: 10.1002/anie.201006327)
CORM-3 reactivity toward proteins: The crystal structure of a Ru(II) dicarbonyl-lysozyme complex
T Santos-Silva, A Mukhopadhyay, JD Seixas, GJL Bernardes, CC Romão, MJ Romão
– Journal of the American Chemical Society
(2011)
133,
1192
(DOI: 10.1021/ja108820s)
Chemical Site-selective Modification of Proteins: Tools for Synthetic Biology
GJL Bernardes
– FASEB JOURNAL
(2011)
25,
Site-selective chemoenzymatic construction of synthetic glycoproteins using endoglycosidases
M Fernández-González, O Boutureira, GJL Bernardes, JM Chalker, MA Young, JC Errey, BG Davis
– Chemical Science
(2010)
1,
709
(DOI: 10.1039/c0sc00265h)
Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting
GJL Bernardes, R Kikkeri, M Maglinao, P Laurino, M Collot, SY Hong, B Lepenies, PH Seeberger
– Organic & biomolecular chemistry
(2010)
8,
4987
(DOI: 10.1039/c0ob00372g)

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