Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
A highly selective, organocatalytic route to chiral 1,2-oxazines from ketones.
– Chem Commun (Camb)
(2006)
3211
(doi: 10.1039/b606338a)
Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools
(2006)
2,
51
(doi: 10.1002/9780470085226.ch2)
Microwave‐Assisted Suzuki Coupling Reactions with an Encapsulated Palladium Catalyst for Batch and Continuous‐Flow Transformations
– Chemistry A European Journal
(2006)
12,
4407
(doi: 10.1002/chem.200501400)
Microwave flow chemistry: the next evolutionary step in synthetic chemistry?
– Chimica Oggi
(2006)
24,
41
Effect of azadirachtin‐derived decalin (perhydronaphthalene) and dihydrofuranacetal (furo[2, 3‐fo]pyran) fragments on the feeding behaviour of Spodoptera littoralis
– Pesticide Science
(2006)
40,
169
(doi: 10.1002/ps.2780400212)
Progress towards avermectins and milbemycins
– Pesticide Science
(2006)
18,
153
(doi: 10.1002/ps.2780180210)
Targeting C-reactive protein for the treatment of cardiovascular disease
– Nature
(2006)
440,
1217
(doi: 10.1038/nature04672)
Chemical variation of natural product-like scaffolds: Design and synthesis of spiroketal derivatives
– Organic & biomolecular chemistry
(2006)
4,
1977
(doi: 10.1039/b603015g)
An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones
– Organic & Biomolecular Chemistry
(2006)
4,
2039
(doi: 10.1039/b601877g)
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