Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

A phase-switch purification approach for the expedient removal of tagged reagents and scavengers following their application in organic synthesis.

J Siu, IR Baxendale, RA Lewthwaite, SV Ley

Organic & biomolecular chemistry

(2005)

3

3140

(doi: 10.1039/b503778f)

Azadirachtin disrupts formation of organised microtubule arrays during microgametogenesis of Plasmodium berghei.

O Billker, MK Shaw, IW Jones, SV Ley, AJ Mordue, RE Sinden

J Eukaryot Microbiol

(2005)

49

489

(doi: 10.1111/j.1550-7408.2002.tb00234.x)

The use of a continuous flow-reactor employing a mixed hydrogen–liquid flow stream for the efficient reduction of imines to amines

S Saaby, KR Knudsen, M Ladlow, SV Ley

Chem Commun (Camb)

(2005)

2909

(doi: 10.1039/b504854k)

Copper- and palladium-containing perovskites: Catalysts for the Ullmann and Sonogashira reactions (pg 1291, 2005)

S Lohmann, SP Andrews, BJ Burke, MD Smith, JP Attfield, H Tanaka, K Kaneko, SV Ley

SYNLETT

(2005)

1490

The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating

IR Baxendale, SV Ley, M Martinelli

Tetrahedron

(2005)

61

5323

(doi: 10.1016/j.tet.2005.03.062)

Integrating Microwave-Assisted Synthesis and Solid-Supported Reagents

IR Baxendale, A Lee, SV Ley

(2005)

133

(doi: 10.1002/9781444305548.ch6)

Total synthesis of antascomicin B

DEA Brittain, CM Griffiths-Jones, MR Linder, MD Smith, C McCusker, JS Barlow, R Akiyama, K Yasuda, SV Ley

Angewandte Chemie International Edition

(2005)

44

2732

(doi: 10.1002/anie.200500174)

Copper- and Palladium-Containing Perovskites: Catalysts for the Ullmann and Sonogashira Reactions

S Ley, S Lohmann, S Andrews, B Burke, M Smith, J Attfield, H Tanaka, K Kaneko

Synlett

(2005)

2005

1291

(doi: 10.1055/s-2005-865233)

Formation of 4-Aminopyrimidines via the Trimerization of Nitriles Using Focused Microwave Heating

IR Baxendale, SV Ley

ACS Combinatorial Science

(2005)

7

483

(doi: 10.1021/cc049826d)

Synthesis of the alkaloid natural products (+)-plicane and (-)-obliquine, using polymer-supported reagents and scavengers

IR Baxendale, SV Ley

Industrial & Engineering Chemistry Research

(2005)

44

8588

(doi: 10.1021/ie048822i)