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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

TOTAL SYNTHESIS OF AVERMECTIN B1A - FINAL COUPLING REACTIONS AND THE TOTAL SYNTHESIS OF AVERMECTIN B1A AGLYCONE
A ARMSTRONG, SV LEY, A MADIN, S MUKHERJEE
– Synlett
(1990)
1990,
328
(doi: 10.1055/s-1990-21080)
TOTAL SYNTHESIS OF AVERMECTIN B1A - SYNTHESIS OF THE C-11-C25 SPIROACETAL FRAGMENT
D DIEZMARTIN, P GRICE, HC KOLB, SV LEY, A MADIN
– Synlett
(1990)
1990,
326
(doi: 10.1055/s-1990-21079)
Total Synthesis of Avermectin B1a: Planning of the Synthesis and Preparation of the C1-C10 »southern» Hydrobenzofuran Fragment
A ARMSTRONG, SV LEY
– Synlett
(1990)
1990,
323
(doi: 10.1055/s-1990-21078)
Total Synthesis of Avermectin B1a: Synthesis of the CarbohydrateBis-Oleandrose Fragment and Coupling to the Avermectin B1a Aglycone
MJ FORD, JG KNIGHT, SV LEY, S VILE
– Synlett
(1990)
1990,
331
(doi: 10.1055/s-1990-21081)
Antifeedant effects of azadirachtin and structurally related compounds on lepidopterous larvae.
WM Blaney, MSJ Simmonds, SV Ley, JC Anderson, PL Toogood
– Entomologia Experimentalis et Applicata.
(1990)
55,
149
(doi: 10.1007/bf00352576)
Azadirachtin: structural requirements for reducing growth and increasing mortality in lepidopterous larvae.
MSJ Simmonds, WM Blaney, SV Ley, JC Anderson, PL Toogood
– Entomologia Experimentalis et Applicata.
(1990)
55,
169
(doi: 10.1111/j.1570-7458.1990.tb01360.x)
A Simple, One-Pot, Glycosidation Procedurevia(1-Imidazolylcaronyl) Glycosides and Zinc Bromide
MJ FORD, SV LEY
– Synlett
(1990)
1990,
255
(doi: 10.1055/s-1990-21053)
Alkenylcyclic sulphites as novel precursors for the preparation of π-allyltricarbonyliron lactone complexes
M CARUSO, JG KNIGHT, SV LEY
– Synlett
(1990)
1990,
224
(doi: 10.1055/s-1990-21044)
ASSESSMENT OF BUTENE-1,4-DIOLS AS STARTING MATERIALS FOR THE PREPARATION OF PI-ALLYLTRICARBONYLIRON COMPLEXES
RW BATES, D DIEZMARTIN, WJ KERR, JG KNIGHT, SV LEY, A SAKELLARIDIS
– Tetrahedron
(1990)
46,
4063
(doi: 10.1016/S0040-4020(01)90541-1)
Direct substitution of 2-benzenesulphonylpiperidines and - Pyrrolidines by carbon nucleophiles: Synthesis of the pyrrolidine alkaloid ruspolinone
DS BROWN, T HANSSON, SV LEY
– Synlett
(1990)
1990,
48
(doi: 10.1055/s-1990-20983)
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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