Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Heterogeneous or Homogeneous? A Case Study Involving Palladium‐Containing Perovskites in the Suzuki Reaction
Advanced Synthesis and Catalysis
(2005)
347
647
(doi: 10.1002/adsc.200404331)
Organic chemistry in ionic liquids using non-thermal energy-transfer processes
Mini-Reviews in Organic Chemistry
(2005)
2
125
(doi: 10.2174/1570193053544454)
Stereoselective synthesis of (2R,3S,4S,5R)-trans-3,4-dihydroxy-5-(4-fluorophenoxymethyl)-2-(1-N-hydroxyureidyl-3-butyn-4-yl)tetrahydrofuran and (2R,3S,4S,5R)-trans-5-ethynyl-2-(4-fluorophenoxymethyl)-3,4-O-isopropylidene tetrahydrofuran from mannose diacetonide
Tetrahedron Asymmetry
(2005)
16
1135
(doi: 10.1016/j.tetasy.2005.01.046)
Stereoselective syntheses of pharmaceutically relevant chiral tetrahydrofurans from (S)- and (R)-glyceraldehyde derivatives
Tetrahedron Asymmetry
(2005)
16
1113
(doi: 10.1016/j.tetasy.2005.01.044)
Stereoselective synthesis of chiral tetrahydrofurans with potent 5-LO inhibitory activity
Tetrahedron Asymmetry
(2005)
16
1125
(doi: 10.1016/j.tetasy.2005.01.045)
New generation synthesis of the ef fragment of the spongistatins.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2005)
229
U520
Towards the total synthesis of bengazole A
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2005)
229
U515
Development of an enantioselective organocatalytic intramolecular cyclopropanation reaction.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2005)
229
U366
Efficient batch and continuous flow Suzuki cross-coupling reactions under mild conditions, catalysed by polyurea-encapsulated palladium ( ii ) acetate and tetra- n -butylammonium salts
Chemical Communications
(2005)
2175
(doi: 10.1039/b418669a)
Stereoselective synthesis of (2S,7S)-7-(4-phenoxymethyl)-2-(1-N- hydroxyureidyl-3-butyn-4-yl)oxepane: A potential anti-asthmatic drug candidate
Tetrahedron Asymmetry
(2005)
16
935
(doi: 10.1016/j.tetasy.2005.01.024)
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