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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Protecting Groups: Effects on Reactivity, Glycosylation Stereoselectivity, and Coupling Efficiency
LG Green, SV Ley
(2008)
1-4,
427
(doi: 10.1002/9783527618255.ch17)
A general organocatalytic enantioselective nitrocyclopropanation reaction
V Wascholowski, HM Hansen, DA Longbottom, SV Ley
– Synthesis
(2008)
2008,
1269
(doi: 10.1055/s-2008-1042944)
New opportunities for advanced organic synthesis-flow-based chemical processing
M Baumann, IR Baxendale, JJ Hayward, MD Hopkin, J Jin, MO Kitching, S Lanners, SV Ley, N Nikbin-Roudsari, CD Smith, CJ Smith, L Tamborini
– JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2008)
51,
252
(link to publication)
The changing face of organic synthesis
SV Ley, IR Baxendale
– Chimia
(2008)
62,
162
(doi: 10.2533/chimia.2008.162)
An electrophysiological and behavioural study of insect antifeedant properties of natural and synthetic drimane‐related compounds
WM BLANEY, MSJ SIMMONDS, SV LEY, RB KATZ
– Physiological entomology
(2008)
12,
281
(doi: 10.1111/j.1365-3032.1987.tb00752.x)
Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions
M Baumann, IR Baxendale, SV Ley, N Nikbin, CD Smith
– Organic & biomolecular chemistry
(2008)
6,
1587
(doi: 10.1039/b801634h)
A modular flow reactor for performing Curtius rearrangements as a continuous flow process.
M Baumann, IR Baxendale, SV Ley, N Nikbin, CD Smith, JP Tierney
– Organic & Biomolecular Chemistry
(2008)
6,
1577
(doi: 10.1039/b801631n)
Facile, one-step production of niacin (vitamin B3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst
R Raja, JM Thomas, M Greenhill-Hooper, SV Ley, FA Almeida Paz
– Chemistry A European Journal
(2008)
14,
2340
(doi: 10.1002/chem.200701679)
Functionalised butanediacetal-protected 1,2-diols as suitable partners for Pd-catalysed cross-coupling reactions
A Leyva, FE Blum, PR Hewitt, SV Ley
– Tetrahedron
(2008)
64,
2348
(doi: 10.1016/j.tet.2008.01.010)
Facile, one-step production of niacin (Vitamin B-3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst
R Raja, JM Thomas, M Greenhill-Hooper, SV Ley, FA Almeida Paz
– Chemistry
(2008)
14,
2340
(doi: 10.1002/chem.200701679)
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Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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