Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Chiral glycolate equivalents for the asymmetric synthesis of α-hydroxycarbonyl compounds
Bulletin of the Chemical Society of Japan
(2007)
80
1451
(doi: 10.1246/bcsj.80.1451)
Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines.
Organic & biomolecular chemistry
(2007)
5
2758
(doi: 10.1039/b709043a)
Total synthesis of five thapsigargins: guaianolide natural products exhibiting sub-nanomolar SERCA inhibition.
Chemistry – A European Journal
(2007)
13
5688
(doi: 10.1002/chem.200700302)
Total synthesis of potent antifungal marine bisoxazole natural products bengazoles A and B.
Chemistry (Weinheim an der Bergstrasse, Germany)
(2007)
13
5515
(doi: 10.1002/chem.200700033)
Pharmaceutical strategy and innovation: an academics perspective.
ChemMedChem
(2007)
2
768
(doi: 10.1002/cmdc.200700008)
(S)- and (R)-5-Pyrrolidin-2-yl-1H-tetrazoles: Enantiomeric organocatalysts of broad utility in organic synthesis
Chimia
(2007)
61
247
(doi: 10.2533/chimia.2007.247)
Solid Supported Reagents in Multi-Step Flow Synthesis
Ernst Schering Foundation Symposium Proceedings
(2007)
2006/3
151
(doi: 10.1007/2789_2007_033)
Chromatography-free Suzuki reactions using a polymer-assisted solution-phase (PASP) approach
Synlett
(2007)
2007
1251
(doi: 10.1055/s-2007-977457)
A microcapillary flow disc reactor for organic synthesis
Organic Process Research and Development
(2007)
11
399
(doi: 10.1021/op700015f)
[3+2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor
Organic & Biomolecular Chemistry
(2007)
5
1559
(doi: 10.1039/b702995k)
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