Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
A general organocatalytic enantioselective nitrocyclopropanation reaction
– Synthesis
(2008)
2008,
1269
(doi: 10.1055/s-2008-1042944)
New opportunities for advanced organic synthesis-flow-based chemical processing
– J LABELLED COMPD RAD
(2008)
51,
252
An electrophysiological and behavioural study of insect antifeedant properties of natural and synthetic drimane‐related compounds
– Physiological Entomology.
(2008)
12,
281
Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions.
– Organic & Biomolecular Chemistry
(2008)
6,
1587
(doi: 10.1039/b801634h)
A modular flow reactor for performing Curtius rearrangements as a continuous flow process.
– Organic and Biomolecular Chemistry
(2008)
6,
1577
(doi: 10.1039/b801631n)
Facile, one-step production of niacin (vitamin B3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst
– Chemistry - A European Journal
(2008)
14,
2340
(doi: 10.1002/chem.200701679)
Functionalised butanediacetal-protected 1,2-diols as suitable partners for Pd-catalysed cross-coupling reactions
– Tetrahedron
(2008)
64,
2348
(doi: 10.1016/j.tet.2008.01.010)
Facile, one-step production of niacin (vitamin B3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst.
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2008)
14,
2340
(doi: 10.1002/chem.200701679)
Azeotropic reflux chromatography: an efficient solution to a difficult separation in the scale-up synthesis of spongistatin 1.
– Organic & Biomolecular Chemistry
(2008)
6,
1159
(doi: 10.1039/b719569a)
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