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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.
IR Baxendale, SV Ley, CD Smith, L Tamborini, AF Voica
– Journal of combinatorial chemistry
(2008)
10,
851
(doi: 10.1021/cc800070a)
Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Pyrroles
GE Veitch, KL Bridgwood, K Rands-Trevor, SV Ley
– Synlett
(2008)
2008,
2597
(doi: 10.1055/s-0028-1083504)
Enantiopure 2-substituted glyceraldehyde derivatives by aza-Claisen rearrangement or C-alkylation of enamines.
KL Bridgwood, CC Tzschucke, M O'Brien, S Wittrock, JM Goodman, JE Davies, AWJ Logan, MRM Hüttl, SV Ley
– Organic Letters
(2008)
10,
{4537-4540}
(doi: 10.1021/ol8018242)
A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.
IR Baxendale, SV Ley, CD Smith, L Tamborini, A-F Voica
– J Comb Chem
(2008)
10,
851
(doi: 10.1021/cc800070a)
Organic Chemistry in Microreactors
T Fukuyama, MT Rahman, I Ryu, IR Baxendale, JJ Hayward, S Lanners, SV Ley, CD Smith, B Ahmed-Omer, T Wirth, V Hessel, P Löb, H Löwe, K Koch, FPJT Rutjes, JCM Van Hest
(2008)
59
(doi: 10.1002/9783527622856.ch4)
A tribute to Professor Ryoji Noyori on the occasion of his 70(th) birthday
JP Richmond, M Banwell, D Bellus, K Muniz, K Narasaka, Y Okamoto, J Okuda, M Schlosser, I Shinkai, K Tatsuta, G van Koten, XZ You, VK Aggarwal, T Aida, H Alper, CL Bai, K Bhattacharyya, HU Blaser, B Pugin, F Spindler, JM Brown, SL Buchwald, ASC Chan, N Chatani, SE Denmark, F Diederich, MP Doyle, G Fu, A Fujishima, S Hanessian, S Hashimoto, M Hayashi, T Hiyama, P Hofmann, ZM Hou, T Imamoto, K Izawa, E Jacobsen, T Katsuki, S Kim, S Kobayashi, K Komatsu, H Kumobayashi, EP Kundig, E Lee, W Leitner, SV Ley, B Lipshutz, YX Lu, K Maruoka, S Murahashi, S Murai, KC Nicolaou, H Nishiyama, T Ohkuma, T Ohta, K Oshima, J Otera, A Pfaltz, MT Reetz, A Ricci, M Sawamoto, M Scalone, KB Sharpless, R Sheldon, V Snieckus, M Sodeoka, M Tokunaga, K Tomioka, Y Umezawa, Y Uozumi, CH Wong, HNC Wong, Y Yamamoto, DB Zhu
– ADV SYNTH CATAL
(2008)
350,
1925
(link to publication)
The use of diethylaminosulfur trifluoride (DAST) for fluorination in a continuous-flow microreactor
M Baumann, IR Baxendale, SV Ley
– Synlett
(2008)
2008,
2111
(doi: 10.1055/s-2008-1078026)
New tools for molecule makers: Emerging technologies
SV Ley
– VDI Berichte
(2008)
5
Magnesium nitride as a convenient source of ammonia: Preparation of dihydropyridines
KL Bridgwood, GE Veitch, SV Ley
– Org Lett
(2008)
10,
3627
(doi: 10.1021/ol801399w)
Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Primary Amides
GE Veitch, KL Bridgwood, SV Ley
– Organic letters
(2008)
10,
3623
(doi: 10.1021/ol801398z)
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Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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