Professor Steve Ley CBE FRS FMedSci | Page 26 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Piperazic acid -containing natural products : Isolation, biological relevance and total synthesis

AJ Oelke, DJ France, T Hofmann, G Wuitschik, SV Ley

– Natural product reports

(2011)

28,

1445

(doi: 10.1039/c1np00041a)

Hydrogenation in flow: Homogeneous and heterogeneous catalysis using Teflon AF-2400 to effect gas–liquid contact at elevated pressure

M O'Brien, N Taylor, A Polyzos, IR Baxendale, SV Ley

– Chemical Science

(2011)

2,

1250

(doi: 10.1039/c1sc00055a)

Topics in Current Chemistry: Foreword

SV Ley

(2011)

301,

(doi: 10.1007/978-3-642-20914-7)

A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures.

DL Browne, M Baumann, BH Harji, IR Baxendale, SV Ley

– Organic letters

(2011)

13,

3312

(doi: 10.1021/ol2010006)

An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

M Baumann, IR Baxendale, M Brasholz, JJ Hayward, SV Ley, N Nikbin

– Synlett

(2011)

2011,

1375

(doi: 10.1055/s-0030-1260573)

The clerodane ring system: Investigating the viability of a direct Diels-Alder approach

AT Merritt, RH Pouwer, DJ Williams, CM Williams, SV Ley

– Organic & biomolecular chemistry

(2011)

9,

4745

(doi: 10.1039/c1ob05422h)

Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods

M Baumann, IR Baxendale, C Kuratli, SV Ley, RE Martin, J Schneider

– ACS combinatorial science

(2011)

13,

405

(doi: 10.1021/co2000357)

A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing

H Lange, CF Carter, MD Hopkin, A Burke, JG Goode, IR Baxendale, SV Ley

– Chemical Science

(2011)

2,

765

(doi: 10.1039/c0sc00603c)

Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme.

G Lupo, G Gestri, M O'Brien, RM Denton, RAS Chandraratna, SV Ley, WA Harris, SW Wilson

– Proceedings of the National Academy of Sciences

(2011)

108,

8698

(doi: 10.1073/pnas.1103802108)

An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals.

M Baumann, IR Baxendale, SV Ley, N Nikbin

– Beilstein journal of organic chemistry

(2011)

7,

442

(doi: 10.3762/bjoc.7.57)