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Yusuf Hamied Department of Chemistry

 

Herchel Smith Professor of Medicinal Chemistry

Nucleic acids are fundamental to life. Our research is focused on the chemical biology of nucleic acids, and employs the principles of chemistry and the molecular sciences to address questions of importance in biology and medicine. Projects are inherently interdisciplinary and will provide scope for a diversity of intellectual and experimental approaches that include: organic synthesis, biophysics, molecular and cellular biology and genomics. Our scientific goals are problem-driven, which constantly raises the need to invent new methodology.

 

A major interest is to elucidate and manipulate mechanisms that control the expression of genes (either transcription, or translation). We are particularly interested in the role of non-canonical nucleic acid structures that control gene expression (e.g. G-quadruplexes, micro RNA and RNA structures in the 5' untranslated regions of mRNAs). Our goal is to design and synthesise small organic molecules that target such structures and alter the expression of certain genes of interest. Such small molecule gene regulators are valuable tools to study mechanisms in biology and will also open up new approaches for therapeutics and molecular medicine, particularly for diseases characterized by aberrant expression of certain genes (e.g. various cancers).

Our fundamental science will inevitably create opportunities for translation and commercialisation. One such example was our invention (with Professor David Klenerman) of new DNA sequencing technology ("Solexa sequencing") that was commercialised as a Cambridge University spinout company (now part of Illumina Inc.) and is used routinely for applications in genomics, including human genome sequencing. 

Hear Shankar Balasubramanian discuss some of the group's research.

Watch Professor Balasubramanian discuss his research

Take a tour of the Balasubramanian Lab

Publications

An upstream G-quadruplex DNA structure can stimulate gene transcription
Y Chen, A Simeone, L Melidis, SM Cuesta, D Tannahill, S Balasubramanian
– ACS Chemical Biology
(2024)
19,
736
G-quadruplex DNA structure is a positive regulator of MYC transcription
I Esain-Garcia, A Kirchner, L Melidis, RDCA Tavares, S Dhir, A Simeone, Z Yu, SK Madden, R Hermann, D Tannahill, S Balasubramanian
– Proceedings of the National Academy of Sciences
(2024)
121,
e2320240121
Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis.
MM Simpson, CC Lam, JM Goodman, S Balasubramanian
– Angew Chem Weinheim Bergstr Ger
(2023)
135,
e202304756
Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis.
MM Simpson, CC Lam, JM Goodman, S Balasubramanian
– Angewandte Chemie - International Edition
(2023)
62,
e202304756
A photoredox reaction for the selective modification of 5-carboxycytosine in DNA
BJ Mortishire-Smith, SM Becker, A Simeone, L Melidis, S Balasubramanian
– J Am Chem Soc
(2023)
145,
10505
Simultaneous sequencing of genetic and epigenetic bases in DNA
J Füllgrabe, WS Gosal, P Creed, S Liu, CK Lumby, DJ Morley, TWB Ost, AJ Vilella, S Yu, H Bignell, P Burns, T Charlesworth, B Fu, H Fordham, NJ Harding, O Gandelman, P Golder, C Hodson, M Li, M Lila, Y Liu, J Mason, J Mellad, JM Monahan, O Nentwich, A Palmer, M Steward, M Taipale, A Vandomme, RS San-Bento, A Singhal, J Vivian, N Wójtowicz, N Williams, NJ Walker, NCH Wong, GN Yalloway, JD Holbrook, S Balasubramanian
– Nat Biotechnol
(2023)
41,
1457
Chem-map profiles drug binding to chromatin in cells.
Z Yu, J Spiegel, L Melidis, WWI Hui, X Zhang, A Radzevičius, S Balasubramanian
– Nat Biotechnol
(2023)
41,
1265
DNA G-Quadruplex Recognition in Vitro and in Live Cells by a Structure-Specific Nanobody
S Galli, L Melidis, SM Flynn, D Varshney, A Simeone, J Spiegel, SK Madden, D Tannahill, S Balasubramanian
– Journal of the American Chemical Society
(2022)
144,
23096
Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA.
IC Navarro, KM Suen, D Bensaddek, A Tanpure, A Lamond, S Balasubramanian, EA Miska
– Wellcome open research
(2022)
7,
282
Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA.
IC Navarro, KM Suen, D Bensaddek, A Tanpure, A Lamond, S Balasubramanian, EA Miska
– Wellcome Open Research
(2022)
7,
282
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Research Group

Research Interest Group

Telephone number

01223 336347

Email address

sb10031@cam.ac.uk