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Yusuf Hamied Department of Chemistry

 

I am now Professor Emeritus, but continue research with several ongoing research grants as Director of Research.

There is a strong interest in the development of novel molecular property calculations and data analysis methods combined with the simulation of biomolecules and materials. Current research interests include drug discovery methods (SAR, simulation of biomolecules and ADME) and molecular data analysis (machine learning, deep learning) as well as drug discovery projects against specific targets. Recent work has seen compounds evaluated in human clinical studies in Addenbrooke's hospital.

 

This example is a simulation of Apelin, a peptide, within the Apelin G-Protein Coupled Receptor. Simulations like this helped us design the first Apelin receptor biased agonists (being investigated for use in in Pulmonary Hypertension (British Journal of Pharmacology (2019)) and competitive antagonists (being investigated for use in glioblastoma- brain tumours (Brain (2017), https://patents.google.com/patent/US20210155659A1/en ).

 

 

Career highlights

I gained my Ph.D. (supervisor Prof. Peter Murray-Rust) in X-ray Crystallography, computational chemistry and Organic Synthesis from the University of Stirling.  One of the highlights was the first co-crystallisation of a reactant and product of a chemical reaction in a single crystal. 

As a Senior Research Scientist at the Wellcome Foundation I guided the development of the Computer-aided Molecular Design group. This included Protein Crystallography (the first in a pharmaceutical company), Molecular Transport properties and Electrochemistry.  I designed the GASP and GOLD computer programs which are used extensively in the pharmaceutical industry, I am a co-inventor of Zomig (a drug for migraine) and invented two other compounds at Wellcome that entered Phase-2 clinical development. 

As Vice President for Collaborative Research at Tripos Inc., a biotechnology company in St. Louis Mo. we created the first commercial screening library, Optiverse (100K compounds), and I assisted in setting up three biotechnology companies (Arena Pharmaceuticals, Phase-1 Molecular Toxicology and Signase).  I obtained and directed a significant BBSRC grant with University College London (discovering activators of soluble guanylate cyclise and working with The Technology Partnership to develop the Baseplate robot) and managed collaborative research and contract research in drug discovery with many large Pharmaceutical companies. Two of the research programs resulted in drugs for obesity (lorcaserin) and sleep disorders/alzheimers (nelotanserin).

In 1999 I moved to the University of Cambridge as Founding Director of the Unilever Centre for Molecular Sciences Informatics, a new institute as part of the Chemistry department, now the Centre for Molecular Informatics, part of the Theoretical Group.

I have served on the boards of a number of emerging biotech and technology companies and serve on a number of grant awarding bodies and am a Fellow of Clare College Cambridge. I have been a consultant to many large pharma companies. I have additionally received over £20M in grants over the last ten years, from Wellcome Trust, NHS, EPSRC, BBSRC, DTI, MRC and Pharmaceutical and software companies.

I was recently elected Professor of Computational Medicine at Imperial College London, and direct several groups working on Big Data projects in diverse areas such as metabonomics, clinical data analysis, imaging (the first imaging of a tumour in 3D using mass spectrometry - Chem. Sci. (2017), Analytical Chemistry (2019), Cell (2021)), bioinformatics and machine learning/AI.

Teaching

Teaching commitments are principally now mentoring and examination.

Lectures

I lecture regularly at conferences, in companies and to  undergraduates and post graduates. e.g. The Gordon Converence on CAMD, 2021 - recently cancelled! Maybe in 2022!

Environment

The Centre for Molecular Informatics has four research groups, Glen, Goodman, Bender and Colwell with currently about thirty research staff.

Further Funding Information

We receive funding from most research councils, the EU, charities and companies. We thank them all and are very grateful to all our funders, particularly Unilever whose generosity founded the Centre for Molecular INformatics.

Publications

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors
ML Boby, D Fearon, M Ferla, M Filep, L Koekemoer, MC Robinson, COVID Moonshot Consortium‡, JD Chodera, AA Lee, N London, A von Delft, F von Delft, H Achdout, A Aimon, DS Alonzi, R Arbon, JC Aschenbrenner, BH Balcomb, E Bar-David, H Barr, A Ben-Shmuel, J Bennett, VA Bilenko, B Borden, P Boulet, GR Bowman, L Brewitz, J Brun, S Bvnbs, M Calmiano, A Carbery, DW Carney, E Cattermole, E Chang, E Chernyshenko, A Clyde, JE Coffland, G Cohen, JC Cole, A Contini, L Cox, TI Croll, M Cvitkovic, S De Jonghe, A Dias, K Donckers, DL Dotson, A Douangamath, S Duberstein, T Dudgeon, LE Dunnett, P Eastman, N Erez, CJ Eyermann, M Fairhead, G Fate, O Fedorov, RS Fernandes, L Ferrins, R Foster, H Foster, L Fraisse, R Gabizon, A García-Sastre, VO Gawriljuk, P Gehrtz, C Gileadi, C Giroud, WG Glass, RC Glen, I Glinert, AS Godoy, M Gorichko, T Gorrie-Stone, EJ Griffen, A Haneef, S Hassell Hart, J Heer, M Henry, M Hill, S Horrell, QYJ Huang, VD Huliak, MFD Hurley, T Israely, A Jajack, J Jansen, E Jnoff, D Jochmans, T John, B Kaminow, L Kang, AL Kantsadi, PW Kenny, JL Kiappes, SO Kinakh, B Kovar, T Krojer, VNT La, S Laghnimi-Hahn, BA Lefker, H Levy, RM Lithgo, IG Logvinenko, P Lukacik, HB Macdonald, EM MacLean, LL Makower, TR Malla, PG Marples, T Matviiuk, W McCorkindale, BL McGovern, S Melamed, KP Melnykov, O Michurin, P Miesen, H Mikolajek, BF Milne, D Minh, A Morris, GM Morris, MJ Morwitzer, D Moustakas, CE Mowbray, AM Nakamura, JB Neto, J Neyts, L Nguyen, GD Noske, V Oleinikovas, G Oliva, GJ Overheul, CD Owen, R Pai, J Pan, N Paran, AM Payne, B Perry, M Pingle, J Pinjari, B Politi, A Powell, V Pšenák, I Pulido, R Puni, VL Rangel, RN Reddi, P Rees, SP Reid, L Reid, E Resnick, EG Ripka, RP Robinson, J Rodriguez-Guerra, R Rosales, DA Rufa, K Saar, KS Saikatendu, E Salah, D Schaller, J Scheen, CA Schiffer, CJ Schofield, M Shafeev, A Shaikh, AM Shaqra, J Shi, K Shurrush, S Singh, A Sittner, P Sjö, R Skyner, A Smalley, B Smeets, MD Smilova, LJ Solmesky, J Spencer, C Strain-Damerell, V Swamy, H Tamir, JC Taylor, RE Tennant, W Thompson, A Thompson, S Tomásio, CWE Tomlinson, IS Tsurupa, A Tumber, I Vakonakis, RP van Rij, L Vangeel, FS Varghese, M Vaschetto, EB Vitner, V Voelz, A Volkamer, MA Walsh, W Ward, C Weatherall, S Weiss, KM White, CF Wild, KD Witt, M Wittmann, N Wright, Y Yahalom-Ronen, NK Yilmaz, D Zaidmann, I Zhang, H Zidane, N Zitzmann, SN Zvornicanin
– Science (New York, N.Y.)
(2023)
382,
eabo7201
Apelinergic signalling in hepatocellular carcinoma (HCC): A new therapeutic treatment option
J Beaumont, E Aboagye, B Wojciak-Stothard, G Serrano-De-Almeida, R Glen, R Sharma
– CANCER RESEARCH
(2022)
82,
Apelinergic signalling in hepatocellular carcinoma (HCC): A new therapeutic treatment option.
J Beaumont, E Aboagye, B Wojciak-Stothard, G Serrano-De-Almeida, R Glen, R Sharma
– CANCER RESEARCH
(2022)
82,
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids.
J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, R Roverts, D Daviran, LAS Fermin, B Willemsen, M Beukenboom, S Djudjaj, S von Stillfried, LE van Eijk, M Mastik, M Bulthuis, WD Dunnen, H van Goor, J-L Hillebrands, SH Triana, T Alexandrov, M-C Timm, BT van den Berge, M van den Broek, Q Nlandu, J Heijnert, EMJ Bindels, RM Hoogenboezem, F Mooren, C Kuppe, P Miesen, K Grünberg, T Ijzermans, EJ Steenbergen, J Czogalla, MF Schreuder, N Sommerdijk, A Akiva, P Boor, VG Puelles, J Floege, TB Huber, COVID Moonshot consortium, RP van Rij, IG Costa, RK Schneider, B Smeets, R Kramann
– Cell stem cell
(2021)
29,
217
Regulation of blood brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide
L Hoyles, MG Pontifex, I Rodriguez-Ramiro, MA Anis-Alavi, KS Jelane, T Snelling, E Solito, S Fonseca, AL Carvalho, SR Carding, M Müller, RC Glen, D Vauzour, S McArthur
– Microbiome
(2021)
9,
235
IonFlow: a galaxy tool for the analysis of ionomics data sets
J Iacovacci, W Lin, JL Griffin, RC Glen
– Metabolomics
(2021)
17,
91
G392E neuroserpin causing the dementia FENIB is secreted from cells but is not synaptotoxic.
T Ingwersen, C Linnenberg, E D'Acunto, S Temori, I Paolucci, D Wasilewski, B Mohammadi, J Kirchmair, RC Glen, E Miranda, M Glatzel, G Galliciotti
– Sci Rep
(2021)
11,
8766
Structure‐based identification of dual ligands at the A 2A R and PDE10A with anti‐proliferative effects in lung cancer cell‐lines
L Kalash, I Winfield, D Safitri, M Bermudez, S Carvalho, R Glen, G Ladds, A Bender
– J Cheminform
(2021)
13,
17
Multiple-testing correction in metabolome-wide association studies.
A Peluso, R Glen, TMD Ebbels
– BMC bioinformatics
(2021)
22,
67
The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo.
C Read, D Nyimanu, P Yang, RE Kuc, TL Williams, CM Fitzpatrick, R Foster, RC Glen, JJ Maguire, AP Davenport
– Frontiers in Pharmacology
(2021)
11,
588669
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Research Group

Research Interest Groups

Telephone number

01223 336472

Email address

rcg28@cam.ac.uk