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Dr Paul Barker

Portrait of pdb30

Research in my group can be divided into two areas, although these share a common theme of engineering metal protein interactions in novel ways.

One goal is to engineer novel proteins and polypeptide based assemblies that can be used in molecular electronic devices and nanotechnology in general. This involves understanding, at a fundamental level, how metal cofactors, particularly heme, is delivered to proteins in vivo and, in the case of c-type cytochromes, how heme is covalently attached to protein. It also involves understanding how functional protein units can be assembled into larger nanoscale assemblies that gain function through the proximity of the constituent monomers.

The other goal is to explore the interaction of 4d and 5d tranistion metals with proteins, particularly as a possible route to finding novel medicinal compounds. Specifically, Ruthenium organometallic complexes have shown some potential as anti cancer compounds, but little is understood about how the chemistry of Ruthenium interacts with biomolecules.


Research Interests


  • Self Assembly of Proteins into functional materials
  • Heme protein assembly and heme chaperones
  • Electrochemistry of Proteins
  • Heavy metal complexes and ther interaction with Proteins


Synthesis and extensive characterisation of phosphorus doped graphite
PD Matthews, TC King, H Glass, PCMM Magusin, GJ Tustin, PAC Brown, JA Cormack, R García-Rodríguez, M Leskes, SE Dutton, PD Barker, FM Grosche, A Alavi, CP Grey, DS Wright
– RSC Advances
How to make a porphyrin flip: Dynamics of asymmetric porphyrin oligomers
C Shang, JM Philpott, N Bampos, PD Barker, DJ Wales
– Physical chemistry chemical physics : PCCP
Investigating the mechanisms of amylolysis of starch granules by solution-state NMR
AJ Baldwin, DL Egan, FJ Warren, PD Barker, CM Dobson, PJ Butterworth, PR Ellis
– Biomacromolecules
Theory and Practice: Bulk Synthesis of C 3 B and its H 2 - and Li-Storage Capacity
TC King, PD Matthews, H Glass, JA Cormack, JP Holgado, M Leskes, JM Griffin, OA Scherman, PD Barker, CP Grey, SE Dutton, RM Lambert, G Tustin, A Alavi, DS Wright
– Angew Chem Int Ed Engl
Selective lability of ruthenium(II) arene amino acid complexes.
TG Scrase, MJ O'Neill, AJ Peel, PW Senior, PD Matthews, H Shi, SR Boss, PD Barker
– Inorg Chem
Folates are potential ligands for ruthenium compounds in vivo.
TG Scrase, SM Page, PD Barker, SR Boss
– Dalton transactions (Cambridge, England : 2003)
Local Frustration Determines Molecular and Macroscopic Helix Structures
CJ Forman, SN Fejer, D Chakrabarti, PD Barker, DJ Wales
– J Phys Chem B
Probing the location of displayed cytochrome b562 on amyloid by scanning tunnelling microscopy.
CJ Forman, N Wang, ZY Yang, CG Mowat, S Jarvis, C Durkan, PD Barker
– Nanotechnology
The morphology of decorated amyloid fibers is controlled by the conformation and position of the displayed protein
CJ Forman, AA Nickson, SJ Anthony-Cahill, AJ Baldwin, G Kaggwa, U Feber, K Sheikh, SP Jarvis, PD Barker
– ACS Nano
Continued surprises in the cytochrome c biogenesis story
EB Sawyer, PD Barker
– Protein & Cell
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Research Group

Research Interest Groups

Telephone number

01223 763096

Email address