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Yusuf Hamied Department of Chemistry

 

Professor Michele Vendruscolo

Professor of Biophysics

Our research

In the last 15 years our research has been focused on the development of methods of characterising the structure, dynamics and interactions of proteins in previously inaccessible states. These methods are based on the use of experimental data, in particular from nuclear magnetic resonance spectroscopy, as structural restraints in molecular dynamics simulations. Through this approach it is possible to obtain information about a variety of protein conformations, as for example those populated during the folding process, and about protein interactions in complex environments, including those generating aggregate species that are associated with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.

Application to neurodegenerative diseases

More recently, these studies have led us to investigate the physico-chemical principles of proteins homeostasis and their application to the development of therapeutic strategies against neurodegenerative diseases. Starting from the observation that proteins are expressed in the cell at levels close to their solubility limits, we are developing approaches to prevent or delay misfolding disorders based on the enhancement of our quality control mechanisms against protein aggregation.

Watch Professor Vendruscolo discuss his research

Take a tour of the Una Finlay Laboratory in the Centre for Misfolding Diseases

Publications

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies.
M Pickhardt, T Neumann, D Schwizer, K Callaway, M Vendruscolo, D Schenk, P St George-Hyslop, EM Mandelkow, CM Dobson, L McConlogue, E Mandelkow, G Tóth
– Current Medicinal Chemistry
(2015)
12,
814
(doi: 10.2174/156720501209151019104951)
Targeting disordered proteins with small molecules using entropy.
GT Heller, P Sormanni, M Vendruscolo
– Trends in biochemical sciences
(2015)
40,
491
(doi: 10.1016/j.tibs.2015.07.004)
Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies
M Pickhardt, EM Mandelkow, E Mandelkow
– Current medicinal chemistry
(2015)
12,
814
(doi: 10.2174/156720501209151019104951)
Chromatin Unfolding by Epigenetic Modifications Explained by Dramatic Impairment of Internucleosome Interactions: A Multiscale Computational Study
R Collepardo-Guevara, G Portella, M Vendruscolo, D Frenkel, T Schlick, M Orozco
– J Am Chem Soc
(2015)
137,
10205
(doi: 10.1021/jacs.5b04086)
A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate.
FA Aprile, P Sormanni, M Vendruscolo
– Biochemistry
(2015)
54,
5103
(doi: 10.1021/acs.biochem.5b00459)
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins.
P Sormanni, FA Aprile, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
9902
(doi: 10.1073/pnas.1422401112)
Probing the Residual Structure of the Low Populated Denatured State of ADA2h under Folding Conditions by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy.
Y Pustovalova, P Kukic, M Vendruscolo, DM Korzhnev
– Biochemistry
(2015)
54,
4611
(doi: 10.1021/acs.biochem.5b00345)
Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution
KD Brewer, T Bacaj, A Cavalli, C Camilloni, JD Swarbrick, J Liu, A Zhou, P Zhou, N Barlow, J Xu, AB Seven, EA Prinslow, R Voleti, D Häussinger, AMJJ Bonvin, DR Tomchick, M Vendruscolo, B Graham, TC Südhof, J Rizo
– Nature Structural and Molecular Biology
(2015)
22,
555
(doi: 10.1038/nsmb.3035)
Constructing free energy landscapes of RNAs at atomic resolution and characterisation of their excited states
AN Borkar, P Vallurupalli, C Camilloni, LE Kay, M Vendruscolo
– Journal of Biomolecular Structure and Dynamics
(2015)
33,
56
(doi: 10.1080/07391102.2015.1032706)
89 Constructing free energy landscapes of RNAs at atomic resolution and characterisation of their excited states
AN Borkar, P Vallurupalli, C Camilloni, LE Kay, M Vendruscolo
– Journal of biomolecular structure & dynamics
(2015)
33 Suppl 1,
58
(doi: 10.1080/07391102.2015.1032706)
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Telephone number

01223 763873

Email address

mv245@cam.ac.uk

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