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Yusuf Hamied Department of Chemistry

 

Professor Michele Vendruscolo

Professor of Biophysics

Our research

In the last 15 years our research has been focused on the development of methods of characterising the structure, dynamics and interactions of proteins in previously inaccessible states. These methods are based on the use of experimental data, in particular from nuclear magnetic resonance spectroscopy, as structural restraints in molecular dynamics simulations. Through this approach it is possible to obtain information about a variety of protein conformations, as for example those populated during the folding process, and about protein interactions in complex environments, including those generating aggregate species that are associated with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.

Application to neurodegenerative diseases

More recently, these studies have led us to investigate the physico-chemical principles of proteins homeostasis and their application to the development of therapeutic strategies against neurodegenerative diseases. Starting from the observation that proteins are expressed in the cell at levels close to their solubility limits, we are developing approaches to prevent or delay misfolding disorders based on the enhancement of our quality control mechanisms against protein aggregation.

Watch Professor Vendruscolo discuss his research

Take a tour of the Una Finlay Laboratory in the Centre for Misfolding Diseases

Publications

Effects of Amyloid-Beta Expression on Neuronal Signalling Pathways in a Novel C. elegans Model of Alzheimer's Disease
T Sinnige, P Ciryam, CM Dobson, M de Bono, M Vendruscolo
– Biophysical Journal
(2017)
112,
159A
(doi: 10.1016/j.bpj.2016.11.878)
Characterization of Protein Kinase a Free Energy Landscape by NMR-Restrained Metadynamics
Y Wang, C Camilloni, J Kim, M Vendruscolo, J Gao, G Veglia
– Biophysical Journal
(2017)
112,
50A
(doi: 10.1016/j.bpj.2016.11.310)
Structural Investigation of an Immunoglobulin Domain on the Ribosome using NMR Spectroscopy
AME Cassaignau, HMM Launay, CA Waudby, T Wlodarski, M-E Karyadi, AL Robertson, X Wang, C Camilloni, M Vendruscolo, CA Woolhead, L Cabrita, J Christodoulou
– Biophysical Journal
(2017)
112,
41A
(doi: 10.1016/j.bpj.2016.11.258)
Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop.
AN Borkar, P Vallurupalli, C Camilloni, LE Kay, M Vendruscolo
– Phys Chem Chem Phys
(2017)
19,
2797
(doi: 10.1039/c6cp08313g)
Networks of Dynamic Allostery Regulate Enzyme Function.
MJ Holliday, C Camilloni, GS Armstrong, M Vendruscolo, EZ Eisenmesser
– Structure (London, England : 1993)
(2017)
25,
276
(doi: 10.1016/j.str.2016.12.003)
Principles of protein structural ensemble determination
M Bonomi, GT Heller, C Camilloni, M Vendruscolo
– Current Opinion in Structural Biology
(2017)
42,
106
(doi: 10.1016/j.sbi.2016.12.004)
Mechanisms of Amyloid-β 42 oligomer formation from kinetic analysis
TC Michaels, A Saric, HW Lazell, P Arosio, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S240
(link to publication)
Structural characterisation of the early events in the nucleation-condensation mechanism of folding
P Kukic, Y Pustovalova, C Camilloni, S Gianni, DM Korzhnev, M Vendruscolo
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S347
(link to publication)
Single amyloid aggregates chemical and structural analysis by infrared nanospectroscopy
FS Ruggeri, J Habchi, C Sean, M Vendruscolo, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S370
(link to publication)
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
114,
E200
(doi: 10.1073/pnas.1615613114)
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Telephone number

01223 763873

Email address

mv245@cam.ac.uk

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