Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors
TCT Michaels, A Šarić, G Meisl, GT Heller, S Curk, P Arosio, S Linse, CM Dobson, M Vendruscolo, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2020)
117,
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, SW Chen, J Habchi, A Bigi, RP Kreiser, AK Wright, JA Albright, T Kartanas, JR Kumita, N Cremades, M Zasloff, C Cecchi, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Communications biology
(2020)
3,
Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism
T Sinnige, G Meisl, T Michaels, M Vendruscolo, TPJ Knowles, R Morimoto
(2020)
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation
P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, M Vendruscolo, S Linse, D Klenerman, TPJ Knowles, CM Dobson
– Nature Structural & Molecular Biology
(2020)
27,
Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers
R Limbocker, B Mannini, R Cataldi, S Chhangur, AK Wright, RP Kreiser, JA Albright, S Chia, J Habchi, P Sormanni, JR Kumita, FS Ruggeri, CM Dobson, F Chiti, FA Aprile, M Vendruscolo
– Int J Mol Sci
(2020)
21,
Infrared Nanospectroscopy Reveals the Molecular Interaction Fingerprint of an Aggregation Inhibitor with Single Aβ42 Oligomers
FS Ruggeri, J Habchi, S Chia, M Vendruscolo, T Knowles
(2020)
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation.
E Kelmer Sacramento, JM Kirkpatrick, M Mazzetto, M Baumgart, A Bartolome, S Di Sanzo, C Caterino, M Sanguanini, N Papaevgeniou, M Lefaki, D Childs, S Bagnoli, E Terzibasi Tozzini, D Di Fraia, N Romanov, PH Sudmant, W Huber, N Chondrogianni, M Vendruscolo, A Cellerino, A Ori
– Mol Syst Biol
(2020)
16,
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
FA Aprile, P Sormanni, M Podpolny, S Chhangur, L-M Needham, FS Ruggeri, M Perni, R Limbocker, GT Heller, T Sneideris, T Scheidt, B Mannini, J Habchi, SF Lee, PC Salinas, TPJ Knowles, CM Dobson, M Vendruscolo
– Proc Natl Acad Sci U S A
(2020)
117,
Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy
FS Ruggeri, B Mannini, R Schmid, M Vendruscolo, TPJ Knowles
– Nat Commun
(2020)
11,
Lipid membranes from naked mole-rat brain lipids are cholesterol-rich, highly phase-separated, and sensitive to amyloid-induced damage
D Frankel, M Davies, B Bhushan, Y Kulaberoglu, P Urriola-Munoz, J Bertrand-Michel, MR Pergande, AA Smith, S Preet, TJ Park, M Vendruscolo, K Rankin, SM Cologna, JR Kumita, N Cenac, ES John Smith
(2020)
