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Dr Gonçalo Bernardes


Our research programme is at the interfaces of Chemistry and Biology. It aims at developing novel aqueous, chemoselective methods and their use for selective protein/ligand labelling in vitro and in vivo to understand and influence human disease. For further info on our research and for oportunities please check our research group website.


Development of Antibody-Directed Therapies: Quo Vadis?
T Rodrigues, GJL Bernardes
– Angew Chem Int Ed Engl
The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer
VJ Somovilla, IA Bermejo, IS Albuquerque, N Martínez-Sáez, J Castro-López, F García-Martín, I Compañón, H Hinou, S-I Nishimura, J Jiménez-Barbero, JL Asensio, A Avenoza, JH Busto, R Hurtado-Guerrero, JM Peregrina, GJL Bernardes, F Corzana
– Journal of the American Chemical Society
Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.
AM Freedy, MJ Matos, O Boutureira, F Corzana, A Guerreiro, P Akkapeddi, VJ Somovilla, T Rodrigues, K Nicholls, B Xie, G Jiménez-Osés, KM Brindle, AA Neves, GJL Bernardes
– Journal of the American Chemical Society
Precise Probing of Residue Roles by Post-Translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites.
J Dadová, K-J Wu, PG Isenegger, JC Errey, GJL Bernardes, JM Chalker, L Raich, C Rovira, BG Davis
– ACS central science
Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides.
S Sun, I Compañón, N Martínez-Sáez, JD Seixas, O Boutureira, F Corzana, GJL Bernardes
– Chembiochem
Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils
MJH Worthington, RL Kucera, IS Albuquerque, CT Gibson, A Sibley, AD Slattery, JA Campbell, SFK Alboaiji, KA Muller, J Young, N Adamson, JR Gascooke, D Jampaiah, YM Sabri, SK Bhargava, SJ Ippolito, DA Lewis, JS Quinton, AV Ellis, A Johs, GJL Bernardes, JM Chalker
– Chemistry
Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo.
N Martínez-Sáez, S Sun, D Oldrini, P Sormanni, O Boutureira, F Carboni, I Compañón, MJ Deery, M Vendruscolo, F Corzana, R Adamo, GJL Bernardes
– Angew Chem Int Ed Engl
A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases.
JB Bertoldo, T Rodrigues, L Dunsmore, FA Aprile, MC Marques, LA Rosado, O Boutureira, TB Steinbrecher, W Sherman, F Corzana, H Terenzi, GJL Bernardes
– Chem
Nickel-Catalyzed Azide-Alkyne Cycloaddition To Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water.
WG Kim, ME Kang, JB Lee, MH Jeon, S Lee, J Lee, B Choi, PMSD Cal, S Kang, J-M Kee, GJL Bernardes, J-U Rohde, W Choe, SY Hong
– Journal of the American Chemical Society
Inverse electron demand Diels-Alder reactions in chemical biology
BL Oliveira, Z Guo, GJL Bernardes
– Chemical Society reviews
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01223 336305

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