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Yusuf Hamied Department of Chemistry

 

Professor of Chemical Biology

Gonçalo Bernardes is a Professor of Chemical Biology & a Fellow of Trinity Hall College, Cambridge.

What we do

Nature has its own machinery for modifying the structure of proteins. In our research, we’re attempting to mimic this machinery to gain significant therapeutic benefits. We’re engineering chemical reactions that enable us to modify proteins while allowing to choose the precise location in the protein’s structure where we want to install these modifications.

This work has a whole range of applications. For example, we’re currently developing ways of selectively labelling proteins in living cells: this can help us monitor the proteins associated with particular diseases without interfering either with the protein’s structure, function, activity and location or upsetting the cell’s normal functions. Another important potential application for this work is linking cytotoxic drug molecules (molecules that are poisonous to cells) to antibodies and then using the antibody to deliver the drug in a very targeted way to the diseased tissue. This could improve the effectiveness of cancer treatments and reduce their side effects.

These are two examples from among our lines of research that use site-selective and bioorthogonal chemistry to address challenges in biology and medicine. We hope our methods may in future be used in laboratories around the world to help develop new drugs with improved effectiveness and reduced side-effects for some of the most common diseases such as cancer.

Funding

We are funded by the Royal Society, by UKRI (EPSRC) and by the European Commission (Marie Sklodowska Curie actions & European Research Council)

For further information on our research and for opportunities, please check our research group website.

Watch Professor Bernardes discuss his research

Take a tour of the Bernardes Lab

Publications

Homogeneous multi-payload antibody-drug conjugates.
T Journeaux, GJL Bernardes
– Nature chemistry
(2024)
Targeted protein editing with an antibody-based system
M Vendruscolo, O Rimon, J Konc, M Ali, VR Chowdhury, P Sormanni, G Bernardes
(2024)
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin–Drug Conjugates
B Bernardim, J Conde, T Hakala, JB Becher, M Canzano, AV Vasco, TPJ Knowles, J Cameron, GJL Bernardes
– Bioconjugate chemistry
(2024)
35,
132
Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1.
G Lopes Bernardes
– Chembiochem : a European journal of chemical biology
(2024)
25,
e202300736
Machine Learning Uncovers Natural Product Modulators of the 5‑Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms
S Mikutis, S Lawrinowitz, C Kretzer, L Dunsmore, L Sketeris, T Rodrigues, O Werz, GJL Bernardes
– ACS chemical biology
(2023)
19,
217
Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses
IA Bermejo, A Guerreiro, A Eguskiza, N Martínez-Sáez, FS Lazaris, A Asín, VJ Somovilla, I Compañón, TK Raju, S Tadic, P Garrido, J García-Sanmartín, V Mangini, AS Grosso, F Marcelo, A Avenoza, JH Busto, F García-Martín, R Hurtado-Guerrero, JM Peregrina, GJL Bernardes, A Martínez, R Fiammengo, F Corzana
– JACS Au
(2023)
4,
150
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores
SE Sandler, RI Horne, S Rocchetti, R Novak, N-S Hsu, M Castellana Cruz, Z Faidon Brotzakis, RC Gregory, S Chia, GJL Bernardes, UF Keyser, M Vendruscolo
– Journal of the American Chemical Society
(2023)
145,
25776
Merging the Isonitrile-Tetrazine (4+1) Cycloaddition and the Ugi Four-Component Reaction into a Single Multicomponent Process
Y Méndez, AV Vasco, G Ivey, AL Dias, P Gierth, BB Sousa, CD Navo, A Torres-Mozas, T Rodrigues, G Jiménez-Osés, GJL Bernardes
– Angewandte Chemie International Edition
(2023)
62,
e202311186
Merging the Isonitrile‐Tetrazine (4+1) Cycloaddition and the Ugi Four‐Component Reaction into a Single Multicomponent Process
Y Méndez, AV Vasco, G Ivey, AL Dias, P Gierth, BB Sousa, CD Navo, A Torres‐Mozas, T Rodrigues, G Jiménez‐Osés, GJL Bernardes
– Angewandte Chemie
(2023)
135,
Designed Endocytosis-Triggering Proteins mediate Targeted Degradation
B Huang, M Abedi, G Ahn, B Coventry, I Sappington, R Wang, T Schlichthaerle, JZ Zhang, Y Wang, I Goreshnik, CW Chiu, A Chazin-Gray, S Chan, S Gerben, A Murray, S Wang, J O'Neill, R Yeh, A Misquith, A Wolf, LM Tomasovic, DI Piraner, MJD Gonzalez, NR Bennett, P Venkatesh, D Satoe, M Ahlrichs, C Dobbins, W Yang, X Wang, D Vafeados, R Mout, S Shivaei, L Cao, L Carter, L Stewart, JB Spangler, GJL Bernardes, KT Roybal, P Greisen, X Li, C Bertozzi, D Baker
– bioRxiv
(2023)
4,
2023.08.19.553321
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Research Group

Research Interest Groups

Telephone number

01223 336305

Email address

gb453@cam.ac.uk

College

Trinity Hall