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Yusuf Hamied Department of Chemistry

 

Dr. Gonçalo Bernardes is a Reader in Chemical Biology, a Royal Society University Research Fellow & a Fellow of Trinity Hall College, Cambridge.

What we do

Nature has its own machinery for modifying the structure of proteins. In our research, we’re attempting to mimic this machinery to gain significant therapeutic benefits. We’re engineering chemical reactions that enable us to modify proteins while allowing to choose the precise location in the protein’s structure where we want to install these modifications.

This work has a whole range of applications. For example, we’re currently developing ways of selectively labelling proteins in living cells: this can help us monitor the proteins associated with particular diseases without interfering either with the protein’s structure, function, activity and location or upsetting the cell’s normal functions. Another important potential application for this work is linking cytotoxic drug molecules (molecules that are poisonous to cells) to antibodies and then using the antibody to deliver the drug in a very targeted way to the diseased tissue. This could improve the effectiveness of cancer treatments and reduce their side effects.

These are two examples from among our lines of research that use site-selective and bioorthogonal chemistry to address challenges in biology and medicine. We hope our methods may in future be used in laboratories around the world to help develop new drugs with improved effectiveness and reduced side-effects for some of the most common diseases such as cancer.

Funding

We are funded by the Royal Society, by research council grants in both countries (EPSRC and FCT Portugal), and by the EU including through a European Research Council Starting and Proof-of-Concept Grants

For further information on our research and for oportunities, please check our research group website.

Watch Dr Bernardes discuss his research

Take a tour of the Bernardes Lab

Publications

Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, BB Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, SH Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, CC Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes
– ACS Central Science
(2021)
acscentsci.1c00070
The role of reversible and irreversible covalent chemistry in targeted protein degradation
H Kiely-Collins, GE Winter, GJL Bernardes
– Cell chemical biology
(2021)
A structural ensemble of a tau-microtubule complex reveals regulatory tau phosphorylation and acetylation mechanisms
F Brotzakis, P Lindstedt, R Taylor, G Bernardes, M Vendruscolo
(2021)
Systematic Activity Maturation of a Single-Domain Antibody with Non-Canonical Amino Acids through Chemical Mutagenesis
PR Lindstedt, FA Aprile, P Sormanni, R Rakoto, CM Dobson, GJL Bernardes, M Vendruscolo
– Cell chemical biology
(2021)
28,
70
Facile Installation of Post-translational Modifications on the Tau Protein via Chemical Mutagenesis
PR Lindstedt, RJ Taylor, GJL Bernardes, M Vendruscolo
– ACS chemical neuroscience
(2021)
12,
557
Precise protein conjugation technology for the construction of homogenous glycovaccines
A Kitowski, F Corzana, GJL Bernardes
– Drug Discovery Today: Technologies
(2021)
Correction: Correction: Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions
Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GJL Bernardes, TPJ Knowles
– Soft matter
(2021)
17,
201
In Vivo Pretargeting Based on Cysteine-selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry
VFC Ferreira, BL Oliveira, A D'Onofrio, CM Farinha, L Gano, A Paulo, GJL Bernardes, F Mendes
– Bioconjugate chemistry
(2020)
32,
121
Adaptive Optimization of Chemical Reactions with Minimal Experimental Information
D Reker, EA Hoyt, GJL Bernardes, T Rodrigues
– Cell Reports Physical Science
(2020)
1,
100247
Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody
J Macías-León, IA Bermejo, A Asín, A García-García, I Compañón, E Jiménez-Moreno, H Coelho, V Mangini, IS Albuquerque, F Marcelo, JL Asensio, GJL Bernardes, HJ Joshi, R Fiammengo, O Blixt, R Hurtado-Guerrero, F Corzana
– Chemical communications (Cambridge, England)
(2020)
56,
15137
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Research Group

Research Interest Groups

Telephone number

01223 336305

Email address

gb453@cam.ac.uk

College

Trinity Hall