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Yusuf Hamied Department of Chemistry

 

Our major research programme concerns the folding, stability and activity of proteins. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular biology and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, cell culture, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR (we have a 500, 600, 700 and an 800 MHz spectrometers) and x-ray protein crystallography.

Current major projects include: protein folding, misfolding and disease; drug discovery; and structure-activity relationships of proteins involved in cancer and disease.

Although now emeritus, I am still fully active in research with long term funding, including an MRC Programme Grant.

Publications

Contribution of long-range electrostatic interactions to the stabilization of the catalytic transition state of the serine protease subtilisin BPN'
SE Jackson, AR Fersht
– Biochemistry
(2002)
32,
13909
Free energies of hydrolysis of amides and peptides in aqueous solution at 25.deg.
AR Fersht, Y Requena
– Journal of the American Chemical Society
(2002)
93,
3499
FINE-STRUCTURE ACTIVITY ANALYSIS OF MUTATIONS AT POSITION 51 OF TYROSYL-TRANSFER RNA-SYNTHETASE
AR Fersht, AJ Wilkinson, P Carter, G Winter
– Biochemistry
(2002)
24,
5858
FOLDING OF CHYMOTRYPSIN INHIBITOR-2 .2. INFLUENCE OF PROLINE ISOMERIZATION ON THE FOLDING KINETICS AND THERMODYNAMIC CHARACTERIZATION OF THE TRANSITION-STATE OF FOLDING
SE Jackson, AR Fersht
– Biochemistry
(2002)
30,
10436
Quantitative Determination of Helical Propensities from Trifluoroethanol Titration Curves
A Jasanoff, AR Fersht
– Biochemistry
(2002)
33,
2129
Circular dichroism studies of barnase and its mutants: characterization of the contribution of aromatic side chains.
S Vuilleumier, J Sancho, R Loewenthal, AR Fersht
– Biochemistry
(2002)
32,
10303
Movement of the Position of the Transition State in Protein Folding
A Matouschek, DE Otzen, LS Itzhaki, SE Jackson, AR Fersht
– Biochemistry
(2002)
34,
13656
CORRELATIONS BETWEEN KINETIC AND X-RAY ANALYSES OF ENGINEERED ENZYMES - CRYSTAL-STRUCTURES OF MUTANTS CYS-]GLY-35 AND TYR-]PHE-34 OF TYROSYL-TRANSFER RNA-SYNTHETASE
MD Fothergill, AR Fersht
– Biochemistry
(2002)
30,
5157
Folding of barnase in parts.
AD Kippen, J Sancho, AR Fersht
– Biochemistry
(2002)
33,
3778
Histidine residues at the N- and C-termini of alpha-helices: perturbed pKas and protein stability.
J Sancho, L Serrano, AR Fersht
– Biochemistry
(2002)
31,
2253
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