Yusuf Hamied Department of Chemistry

Publications by Professor Sir Alan Fersht FRS

The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)
PJ Carter, G Winter, AJ Wilkinson, AR Fersht
Cell
(1984)
38
(doi: 10.1016/0092-8674(84)90278-2)
Engineering enzymes
G Winter, AR Fersht
Trends in Biotechnology
(1984)
2
(doi: 10.1016/0167-7799(84)90019-2)
Fidelity of DNA replication under conditions used for oligodeoxynucleotide-directed mutagenesis.
JP Shi, AR Fersht
Journal of Molecular Biology
(1984)
177
(doi: 10.1016/0022-2836(84)90456-x)
Genetic dissection of tyrosyl-tRNA synthetase
G WINTER, P CARTER, MMY WAYE, DM BLOW, AJ WILKINSON, J-P SHI, AR FERSHT
Biochemical Society Transactions
(1984)
12
(doi: 10.1042/bst0120224)
Basis of biological specificity
AR Fersht
Trends in Biochemical Sciences
(1984)
9
(doi: 10.1016/0968-0004(84)90122-1)
A large increase in enzyme–substrate affinity by protein engineering
AJ Wilkinson, AR Fersht, DM Blow, P Carter, G Winter
Nature
(1984)
307
(doi: 10.1038/307187a0)
Fidelity of DNA Replication in Vitro
AR Fersht
Adv Exp Med Biol
(1984)
179
(doi: 10.1007/978-1-4684-8730-5_55)
REPLICATION OF PHI-X174 DNA BY CALF THYMUS DNA POLYMERASE-ALPHA - MEASUREMENT OF ERROR RATES AT THE AMBER-16 CODON
F Grosse, G Krauss, JW Knill-Jones, AR Fersht
Adv Exp Med Biol
(1984)
179
(doi: 10.1007/978-1-4684-8730-5_56)
Deletion mutagenesis using an ‘M13 splint’: the N‐terminal structural domain of tyrosyl‐tRNA synthetase (B. stearothermophilus) catalyses the formation of tyrosyl adenylate.
MM Waye, G Winter, AJ Wilkinson, AR Fersht
The EMBO journal
(1983)
2
(doi: 10.1002/j.1460-2075.1983.tb01665.x)
Accuracy of DNA polymerase-alpha in copying natural DNA.
F Grosse, G Krauss, JW Knill-Jones, AR Fersht
The EMBO journal
(1983)
2
(doi: 10.1002/j.1460-2075.1983.tb01616.x)
CONTRIBUTION OF 3'-]5' EXONUCLEASE ACTIVITY OF DNA POLYMERASE-III HOLOENZYME FROM ESCHERICHIA-COLI TO SPECIFICITY
AR Fersht, JW Knill-Jones
Journal of Molecular Biology
(1983)
165
(doi: 10.1016/s0022-2836(83)80273-3)
Fidelity of replication of bacteriophage phi X174 DNA in vitro and in vivo.
AR Fersht, JW Knill-Jones
Journal of molecular biology
(1983)
165
(doi: 10.1016/s0022-2836(83)80271-x)
Kinetics of base misinsertion by DNA polymerase I of Escherichia coli.
AR Fersht, JP Shi, WC Tsui
Journal of Molecular Biology
(1983)
165
(doi: 10.1016/s0022-2836(83)80272-1)
ACCURACY OF DNA POLYMERASE-ALPHA IN COPYING NATURAL DNA
F GROSSE, G KRAUSS, JW KNILLJONES, AR FERSHT
HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE
(1983)
364
Redesigning enzyme structure by site-directed mutagenesis: Tyrosyl tRNA synthetase and ATP binding
G Winter, AR Fersht, AJ Wilkinson, M Zoller, M Smith
Nature
(1982)
299
(doi: 10.1038/299756a0)
Kinetic basis of spontaneous mutation
AR Fersht, JW Knill-Jones, WC Tsui
Journal of molecular biology
(1982)
156
(doi: 10.1016/0022-2836(82)90457-0)
Probing the principles of amino acid selection using the alanyl-tRNA synthetase from Escherichia coli.
WC Tsui, AR Fersht
Nucleic Acids Research
(1981)
9
(doi: 10.1093/nar/9.18.4627)
Enzymic editing mechanisms and the genetic code.
AR Fersht
Proc R Soc Lond B Biol Sci
(1981)
212
(doi: 10.1098/rspb.1981.0044)
Alternative pathways for editing non-cognate amino acids by aminoacyl-tRNA synthetases
H Jakubowski, AR Fersht
Nucleic Acids Research
(1981)
9
(doi: 10.1093/nar/9.13.3105)
DNA polymerase accuracy and spontaneous mutation rates: frequencies of purine.purine, purine.pyrimidine, and pyrimidine.pyrimidine mismatches during DNA replication.
AR Fersht, JW Knill-Jones
Proceedings of the National Academy of Sciences
(1981)
78
(doi: 10.1073/pnas.78.7.4251)
Yusuf Hamied Department of Chemistry
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