Yusuf Hamied Department of Chemistry

Publications by Professor Sir Alan Fersht FRS

The hydrogen bond in molecular recognition
AR Fersht
Trends in Biochemical Sciences
(1987)
12
(doi: 10.1016/0968-0004(87)90146-0)
Concluding comment:–Fersht
AR Fersht
Protein Engineering Design and Selection
(1987)
1
(doi: 10.1093/protein/1.6.446)
SINGLE-STRANDED M13 DNA - USE AS A CLONING VECTOR
MD Jones, NJ Brand, AR Fersht
Nucleic Acids Research
(1986)
14
(doi: 10.1093/nar/14.24.10116)
Catalytic dissection of an enzyme active site
TNC WELLS, AR FERSHT
Biochemical Society Transactions
(1986)
14
(doi: 10.1042/bst0141219)
Protein engineering
RJ Leatherbarrow, AR Fersht
Protein Engineering Design and Selection
(1986)
1
(doi: 10.1093/protein/1.1.7)
Binding energy and catalysis: a lesson from protein engineering of the tyrosyl-tRNA synthetase
AR Fersht, RJ Leatherbarrow, TNC Wells
Trends in Biochemical Sciences
(1986)
11
(doi: 10.1016/0968-0004(86)90289-6)
Protein engineering of homodimeric tyrosyl-tRNA synthetase to produce active heterodimers.
WH Ward, DH Jones, AR Fersht
J Biol Chem
(1986)
261
(doi: 10.1016/s0021-9258(18)67550-7)
Quantitative analysis of structure–activity relationships in engineered proteins by linear free-energy relationships
AR Fersht, RJ Leatherbarrow, TNC Wells
Nature
(1986)
322
(doi: 10.1038/322284a0)
Commercial samples of subtilisin BPN′
AJ RUSSELL, AR FERSHT
Nature
(1986)
321
(doi: 10.1038/321733b0)
Structure and activity of the tyrosy1-tRNA synthetase: the hydrogen bond in catalysis and specificity
AR Fersht, RJ Leatherbarrow, TNC Wells
Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences
(1986)
317
(doi: 10.1098/rsta.1986.0041)
Molecular cloning of the gene encoding the valyl-tRNA synthetase from Bacillus stearothermophilus
NJ Brand, AR Fersht
Gene
(1986)
44
(doi: 10.1016/0378-1119(86)90053-3)
Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering.
RJ Leatherbarrow, AR Fersht, G Winter
Proc Natl Acad Sci U S A
(1985)
82
(doi: 10.1073/pnas.82.23.7840)
Tailoring the pH dependence of enzyme catalysis using protein engineering
PG Thomas, AJ Russell, AR Fersht
Nature
(1985)
318
(doi: 10.1038/318375a0)
Hydrogen bonding in enzymatic catalysis analysed by protein engineering
TNC Wells, AR Fersht
Nature
(1985)
316
(doi: 10.1038/316656a0)
Engineering of tyrosyl tRNA synthetase
H Bedouelle, P Carter, MM Waye, G Winter, DM Lowe, AJ Wilkinson, AR Fersht
Biochimie
(1985)
67
(doi: 10.1016/s0300-9084(85)80161-9)
Hydrogen bonding and biological specificity analysed by protein engineering.
AR Fersht, JP Shi, J Knill-Jones, DM Lowe, AJ Wilkinson, DM Blow, P Brick, P Carter, MM Waye, G Winter
Nature
(1985)
314
(doi: 10.1038/314235a0)
Synthesis of tetrahydrofolate derivatives.
CJ SUCKLING, AR BATTERSBY, SC TAYLOR, D ARIGONI, JR KNOWLES, SM ROBERTS, GM WHITESIDES, JB JONES, AR FERSHT
Ciba Foundation symposium
(1985)
111
NAD+ degradation by resting cells.
H SIMON, GM WHITESIDES, K MOSBACH, AR FERSHT
Ciba Foundation symposium
(1985)
111
ENGINEERING OF TYROSYL TRANSFER-RNA SYNTHETASE
H BEDOUELLE, P CARTER, MMY WAYE, G WINTER, DM LOWE, AJ WILKINSON, AR FERSHT
BIOCHIMIE
(1985)
67
(doi: 10.1016/S0300-9084(85)80161-9)
The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus).
PJ Carter, G Winter, AJ Wilkinson, AR Fersht
Cell
(1984)
38
(doi: 10.1016/0092-8674(84)90278-2)
Yusuf Hamied Department of Chemistry
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