Yusuf Hamied Department of Chemistry

Publications by Professor Sir Alan Fersht FRS

Electrostatic effects on modification of charged groups in the active site cleft of subtilisin by protein engineering
AJ Russell, PG Thomas, AR Fersht
Journal of molecular biology
(1987)
193
(doi: 10.1016/0022-2836(87)90360-3)
Concluding comment:–Fersht
AR Fersht
Protein Engineering Design and Selection
(1987)
1
(doi: 10.1093/protein/1.6.446)
The hydrogen bond in molecular recognition
AR Fersht
Trends in Biochemical Sciences
(1987)
12
(doi: 10.1016/0968-0004(87)90146-0)
Single-stranded M13 DNA: use as a cloning vector.
MD Jones, NJ Brand, AR Fersht
Nucleic Acids Res
(1986)
14
(doi: 10.1093/nar/14.24.10116)
Catalytic dissection of an enzyme active site
TNC WELLS, AR FERSHT
Biochemical Society Transactions
(1986)
14
(doi: 10.1042/bst0141219)
Protein engineering.
RJ Leatherbarrow, AR Fersht
Protein Eng
(1986)
1
(doi: 10.1093/protein/1.1.7)
Binding energy and catalysis: a lesson from protein engineering of the tyrosyl-tRNA synthetase
AR Fersht, RJ Leatherbarrow, TNC Wells
Trends in Biochemical Sciences
(1986)
11
(doi: 10.1016/0968-0004(86)90289-6)
Protein engineering of homodimeric tyrosyl-tRNA synthetase to produce active heterodimers.
WH Ward, DH Jones, AR Fersht
The Journal of biological chemistry
(1986)
261
(doi: 10.1016/s0021-9258(18)67550-7)
Quantitative analysis of structure–activity relationships in engineered proteins by linear free-energy relationships
AR Fersht, RJ Leatherbarrow, TNC Wells
Nature
(1986)
322
(doi: 10.1038/322284a0)
Commercial samples of subtilisin BPN′
AJ RUSSELL, AR FERSHT
Nature
(1986)
321
(doi: 10.1038/321733b0)
Structure and activity of the tyrosy1-tRNA synthetase: the hydrogen bond in catalysis and specificity
AR Fersht, RJ Leatherbarrow, TNC Wells
Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences
(1986)
317
(doi: 10.1098/rsta.1986.0041)
Molecular cloning of the gene encoding the valyl-tRNA synthetase from Bacillus stearothermophilus
NJ Brand, AR Fersht
Gene
(1986)
44
(doi: 10.1016/0378-1119(86)90053-3)
Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering.
RJ Leatherbarrow, AR Fersht, G Winter
Proceedings of the National Academy of Sciences
(1985)
82
(doi: 10.1073/pnas.82.23.7840)
Tailoring the pH dependence of enzyme catalysis using protein engineering
PG Thomas, AJ Russell, AR Fersht
Nature
(1985)
318
(doi: 10.1038/318375a0)
Hydrogen bonding in enzymatic catalysis analysed by protein engineering
TNC Wells, AR Fersht
Nature
(1985)
316
(doi: 10.1038/316656a0)
Engineering of tyrosyl tRNA synthetase.
H Bedouelle, P Carter, MM Waye, G Winter, DM Lowe, AJ Wilkinson, AR Fersht
Biochimie
(1985)
67
(doi: 10.1016/s0300-9084(85)80161-9)
Hydrogen bonding and biological specificity analysed by protein engineering
AR Fersht, JP Shi, J Knill-Jones, DM Lowe, AJ Wilkinson, DM Blow, P Brick, P Carter, MM Waye, G Winter
Nature
(1985)
314
(doi: 10.1038/314235a0)
Synthesis of tetrahydrofolate derivatives.
CJ SUCKLING, AR BATTERSBY, SC TAYLOR, D ARIGONI, JR KNOWLES, SM ROBERTS, GM WHITESIDES, JB JONES, AR FERSHT
Ciba Foundation symposium
(1985)
111
NAD+ degradation by resting cells.
H SIMON, GM WHITESIDES, K MOSBACH, AR FERSHT
Ciba Found Symp
(1985)
111
ENGINEERING OF TYROSYL TRANSFER-RNA SYNTHETASE
H BEDOUELLE, P CARTER, MMY WAYE, G WINTER, DM LOWE, AJ WILKINSON, AR FERSHT
BIOCHIMIE
(1985)
67
(doi: 10.1016/S0300-9084(85)80161-9)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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