Professor of Computational and Molecular Biophysics
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Forced unraveling of chromatin fibers with nonuniform linker DNA lengths
– J Phys Condens Matter
(2015)
27,
064113
Energy Landscapes, Folding Mechanisms, and Kinetics of RNA Tetraloop Hairpins
– Journal of the American Chemical Society
(2014)
52,
18052
(doi: 10.1021/ja5100756)
Structure and Properties of DNA in Apolar Solvents
– J Phys Chem B
(2014)
118,
8540
(doi: 10.1021/jp503816r)
Dynamic condensation of linker histone C-terminal domain regulates chromatin structure
– Nucleic Acids Research
(2014)
42,
7553
(doi: 10.1093/nar/gku491)
Chromatin fiber polymorphism triggered by variations of DNA linker lengths.
– Proceedings of the National Academy of Sciences
(2014)
111,
8061
(doi: 10.1073/pnas.1315872111)
NAFlex: a web server for the study of nucleic acid flexibility
– Nucleic acids research
(2013)
41,
W47
(doi: 10.1093/nar/gkt378)
Insights into chromatin fibre structure by in vitro and in silico single-molecule stretching experiments
– Biochemical Society transactions
(2013)
41,
494
(doi: 10.1042/BST20120349)
Insights into chromatin architecture by mesoscale modeling of oligonucleosomes
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
246,
Crucial role of dynamic linker histone binding and divalent ions for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes
– Nucleic Acids Res
(2012)
40,
8803
(doi: 10.1093/nar/gks600)
The effect of linker histone's nucleosome binding affinity on chromatin unfolding mechanisms.
– Biophysical Journal
(2011)
101,
1670
(doi: 10.1016/j.bpj.2011.07.044)
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