Professor Rosana Collepardo-Guevara

University Professor

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.

Professor Collepardo discusses her research

Publications

A universal code for phase separation of prion-like low complexity domains: Insights from quantitative computer simulations

MJ Maristany, A Aguirre, JA Joseph, R Collepardo-Guevara

Biophysical Journal

(2023)

122

157a

(doi: 10.1016/j.bpj.2022.11.960)

Physical determinants of multiphase organisation in multi-component protein/RNA condensates

PY Chew, JA Joseph, R Collepardo-Guevara, A Reinhardt

Biophysical Journal

(2023)

122

295a

(doi: 10.1016/j.bpj.2022.11.1672)

Thermodynamic origins of two-component multiphase condensates of proteins

PY Chew, JA Joseph, R Collepardo-Guevara, A Reinhardt

Chemical science

(2023)

1820

(doi: 10.1039/d2sc05873a)

Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation

K Brown, PY Chew, S Ingersoll, JR Espinosa, A Aguirre, T Kutateladze, RC Guevara, X Ren

(2022)

(doi: 10.1101/2022.12.26.521954)

Location and concentration of aromatic-rich segments dictates the percolating inter-molecular network and viscoelastic properties of ageing condensates

S Blazquez, I Sanchez-Burgos, J Ramirez, T Higginbotham, MM Conde, R Collepardo-Guevara, AR Tejedor, JR Espinosa

(2022)

(doi: 10.1101/2022.12.14.520383)

Time-dependent material properties of ageing biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations

AR Tejedor, R Collepardo-Guevara, J Ramírez, JR Espinosa

(2022)

(doi: 10.1101/2022.12.07.519428)

The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus.

H Zhu, M Narita, JA Joseph, G Krainer, WE Arter, I Olan, KL Saar, N Ermann, JR Espinosa, Y Shen, MA Kuri, R Qi, TJ Welsh, R Collepardo-Guevara, M Narita, TPJ Knowles

Chembiochem : a European journal of chemical biology

(2022)

e202200450

(doi: 10.1002/cbic.202200450)

Surfactants or scaffolds? RNAs of different lengths exhibit heterogeneous distributions and play diverse roles in RNA-protein condensates

I Sanchez-Burgos, L Herriott, R Collepardo-Guevara, JR Espinosa

(2022)

(doi: 10.1101/2022.11.09.515827)