University Associate Professor
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Forced unraveling of chromatin fibers with nonuniform linker DNA lengths
Journal of Physics: Condensed Matter
(2015)
27
064113
Energy Landscapes, Folding Mechanisms, and Kinetics of RNA Tetra loop Hairpins
Journal of the American Chemical Society
(2014)
52
18052
(doi: 10.1021/ja5100756)
Structure and properties of DNA in apolar solvents
The journal of physical chemistry. B
(2014)
118
8540
(doi: 10.1021/jp503816r)
Dynamic condensation of linker histone C-terminal domain regulates chromatin structure
Nucleic Acids Research
(2014)
42
7553
(doi: 10.1093/nar/gku491)
Chromatin fiber polymorphism triggered by variations of DNA linker lengths
Proceedings of the National Academy of Sciences of the United States of America
(2014)
111
8061
(doi: 10.1073/pnas.1315872111)
NAFlex: a web server for the study of nucleic acid flexibility
Nucleic Acids Res
(2013)
41
w47
(doi: 10.1093/nar/gkt378)
Insights into chromatin fibre structure by in vitro and in silico single-molecule stretching experiments
Biochemical Society Transactions
(2013)
41
494
(doi: 10.1042/BST20120349)
Insights into chromatin architecture by mesoscale modeling of oligonucleosomes
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
246
Crucial role of dynamic linker histone binding and divalent ions for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes
Nucleic Acids Res
(2012)
40
8803
(doi: 10.1093/nar/gks600)
The effect of linker histones nucleosome binding affinity on chromatin unfolding mechanisms
Biophysical journal
(2011)
101
1670
(doi: 10.1016/j.bpj.2011.07.044)
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