University Associate Professor
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Dynamic condensation of linker histone C-terminal domain regulates chromatin structure
Nucleic Acids Research
(2014)
42
7553
(doi: 10.1093/nar/gku491)
Chromatin fiber polymorphism triggered by variations of DNA linker lengths.
Proceedings of the National Academy of Sciences
(2014)
111
8061
(doi: 10.1073/pnas.1315872111)
NAFlex: a web server for the study of nucleic acid flexibility.
Nucleic Acids Research
(2013)
41
w47
(doi: 10.1093/nar/gkt378)
Insights into chromatin fibre structure by in vitro and in silico single-molecule stretching experiments
Biochemical Society Transactions
(2013)
41
494
(doi: 10.1042/bst20120349)
Insights into chromatin architecture by mesoscale modeling of oligonucleosomes
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
246
Crucial role of dynamic linker histone binding and divalent ions for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes
Nucleic acids research
(2012)
40
8803
(doi: 10.1093/nar/gks600)
The Effect of Linker Histone's Nucleosome Binding Affinity on Chromatin Unfolding Mechanisms
Biophys J
(2011)
101
1670
(doi: 10.1016/j.bpj.2011.07.044)
Bimolecular reaction rates from ring polymer molecular dynamics: Application to H+CH4 → H2+CH3
The Journal of chemical physics
(2011)
134
044131
(doi: 10.1063/1.3533275)
Biomolecular modeling and simulation: A field coming of age
Quarterly reviews of biophysics
(2011)
44
191
(doi: 10.1017/S0033583510000284)
Modeling studies of chromatin fiber structure as a function of DNA linker length.
Journal of Molecular Biology
(2010)
403
777
(doi: 10.1016/j.jmb.2010.07.057)
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