University Professor

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
G da Rosa, L Grille, V Calzada, K Ahmad, JP Arcon, F Battistini, G Bayarri, T Bishop, P Carloni, T Cheatham Iii, R Collepardo-Guevara, J Czub, JR Espinosa, R Galindo-Murillo, SA Harris, A Hospital, C Laughton, JH Maddocks, A Noy, M Orozco, M Pasi, A Pérez, D Petkevičiūtė-Gerlach, R Sharma, R Sun, PD Dans
Biophysical reviews
(2021)
13
The chromatin regulator HMGA1a undergoes phase separation in the nucleus
H Zhu, M Narita, JA Joseph, G Krainer, WE Arter, I Olan, KL Saar, N Ermann, JR Espinosa, Y Shen, MA Kuri, R Qi, TJ Welsh, Y Xu, R Collepardo-Guevara, M Narita, TPJ Knowles
(2021)
Can single-component protein condensates form multiphase architectures?
A Garaizar, JR Espinosa, JA Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara
(2021)
RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins
I Sanchez-Burgos, JR Espinosa, JA Joseph, R Collepardo-Guevara
(2021)
Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates
A Garaizar, JR Espinosa, JA Joseph, R Collepardo-Guevara
(2021)
Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence
SM Lichtinger, A Garaizar, R Collepardo-Guevara, A Reinhardt
PLoS Computational Biology
(2021)
17
Size conservation emerges spontaneously in biomolecular condensates formed by scaffolds and surfactant clients.
I Sanchez-Burgos, JA Joseph, R Collepardo-Guevara, JR Espinosa
Scientific Reports
(2021)
11
Liquid-like chromatin in the cell: What can we learn from imaging and computational modeling?
R Collepardo Guevara, E Woods
Current Opinion in Structural Biology
(2021)
71
Nucleosome plasticity is a critical element of chromatin liquid-liquid phase separation and multivalent nucleosome interactions.
SE Farr, EJ Woods, JA Joseph, A Garaizar, R Collepardo-Guevara
Nature communications
(2021)
12
Size conservation emerges spontaneously in biomolecular condensates formed by scaffolds and surfactant clients
I Sanchez-Burgos, JA Joseph, R Collepardo-Guevara, JR Espinosa
(2021)

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