Professor of Computational and Molecular Biophysics
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Reentrant Liquid Condensate Phase of Proteins is Stabilized by Hydrophobic and Non-Ionic interactions
– BIOPHYSICAL JOURNAL
(2020)
120,
2020.05.04.076299
(doi: 10.1101/2020.05.04.076299)
Protein disorder-to-order transition enhances the nucleosome-binding affinity of H1.
– Nucleic acids research
(2020)
48,
5318
(doi: 10.1093/NAR/GKAA285)
Surface electrostatics govern the emulsion stability of biomolecular condensates
(2020)
2020.04.20.047910
(doi: 10.1101/2020.04.20.047910)
Emergence of chromatin hierarchical loops from protein disorder and nucleosome asymmetry
– Proc Natl Acad Sci U S A
(2020)
117,
7216
(doi: 10.1073/pnas.1910044117)
Oligonucleotides can act as superscaffolds that enhance liquid-liquid phase separation of intracellular mixtures
(2020)
2020.01.24.916858
(doi: 10.1101/2020.01.24.916858)
Phosphorylation of Intrinsically Disordered Regions within the Genome
– BIOPHYSICAL JOURNAL
(2020)
118,
296A
Breakdown of the law of rectilinear diameter and related surprises in the liquid-vapor coexistence in systems of patchy particles.
– The Journal of Chemical Physics
(2019)
150,
224510
(doi: 10.1063/1.5098551)
Chromatin Structure Regulation by an Epigenetic Switch Tuning the Flexibility of the H1 C-Terminal Domain
– Biophysical Journal
(2019)
116,
70A
(doi: 10.1016/j.bpj.2018.11.420)
Chromatin unfolding by epigenetic modifications explained by dramatic impairment of internucleosome interactions: A multiscale computational study
– J Am Chem Soc
(2015)
137,
10205
(doi: 10.1021/jacs.5b04086)
Forced unraveling of chromatin fibers with nonuniform linker DNA lengths
– Journal of Physics Condensed Matter
(2015)
27,
064113
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