skip to content
Home

Yusuf Hamied Department of Chemistry

 

Professor Rosana Collepardo-Guevara

Professor of Computational and Molecular Biophysics

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
G da Rosa, L Grille, V Calzada, K Ahmad, JP Arcon, F Battistini, G Bayarri, T Bishop, P Carloni, T Cheatham Iii, R Collepardo-Guevara, J Czub, JR Espinosa, R Galindo-Murillo, SA Harris, A Hospital, C Laughton, JH Maddocks, A Noy, M Orozco, M Pasi, A Pérez, D Petkevičiūtė-Gerlach, R Sharma, R Sun, PD Dans
– Biophysical Reviews
(2021)
13,
995
(doi: 10.1007/s12551-021-00893-8)
The chromatin regulator HMGA1a undergoes phase separation in the nucleus
H Zhu, M Narita, JA Joseph, G Krainer, WE Arter, I Olan, KL Saar, N Ermann, JR Espinosa, Y Shen, MA Kuri, R Qi, TJ Welsh, Y Xu, R Collepardo-Guevara, M Narita, TPJ Knowles
(2021)
2021.10.14.464384
(doi: 10.1101/2021.10.14.464384)
Can single-component protein condensates form multiphase architectures?
A Garaizar, JR Espinosa, JA Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara
(2021)
(doi: 10.1101/2021.10.09.463670)
RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins
I Sanchez-Burgos, JR Espinosa, JA Joseph, R Collepardo-Guevara
(2021)
2021.10.07.463486
(doi: 10.1101/2021.10.07.463486)
Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates
A Garaizar, JR Espinosa, JA Joseph, R Collepardo-Guevara
(2021)
(doi: 10.1101/2021.10.07.463530)
Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence.
SM Lichtinger, A Garaizar, R Collepardo-Guevara, A Reinhardt
– PLoS computational biology
(2021)
17,
e1009328
(doi: 10.1371/journal.pcbi.1009328)
Size conservation emerges spontaneously in biomolecular condensates formed by scaffolds and surfactant clients.
I Sanchez-Burgos, JA Joseph, R Collepardo-Guevara, JR Espinosa
– Scientific reports
(2021)
11,
15241
(doi: 10.1038/s41598-021-94309-y)
Nucleosome plasticity is a critical element of chromatin liquid-liquid phase separation and multivalent nucleosome interactions
SE Farr, EJ Woods, JA Joseph, A Garaizar, R Collepardo-Guevara
– Nature communications
(2021)
12,
2883
(doi: 10.1038/s41467-021-23090-3)
Size conservation emerges spontaneously in biomolecular condensates formed by scaffolds and surfactant clients
I Sanchez-Burgos, JA Joseph, R Collepardo-Guevara, JR Espinosa
(2021)
2021.04.30.442154
(doi: 10.1101/2021.04.30.442154)
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.
G Krainer, TJ Welsh, JA Joseph, JR Espinosa, S Wittmann, E de Csilléry, A Sridhar, Z Toprakcioglu, G Gudiškytė, MA Czekalska, WE Arter, J Guillén-Boixet, TM Franzmann, S Qamar, PS George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
– Nat Commun
(2021)
12,
1085
(doi: 10.1038/s41467-021-21181-9)
  • <
  • 6 of 10
  • >

Research Interest Group

Email address

rc597@cam.ac.uk

College

Clare College

    Study at Cambridge

    About the University

    Research at Cambridge