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Yusuf Hamied Department of Chemistry

 

Professor Rosana Collepardo-Guevara

Professor of Computational and Molecular Biophysics

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Size conservation emerges spontaneously in biomolecular condensates formed by scaffolds and surfactant clients.
I Sanchez-Burgos, JA Joseph, R Collepardo-Guevara, JR Espinosa
– Sci Rep
(2021)
11,
15241
(doi: 10.1038/s41598-021-94309-y)
Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
SE Farr, EJ Woods, JA Joseph, A Garaizar, R Collepardo-Guevara
– Nature Communications
(2021)
12,
2883
(doi: 10.1038/s41467-021-23090-3)
Size conservation emerges spontaneously in biomolecular condensates formed by scaffolds and surfactant clients
I Sanchez-Burgos, J Joseph, R Collepardo-Guevara, J Espinosa
(2021)
2021.04.30.442154
(doi: 10.1101/2021.04.30.442154)
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.
G Krainer, TJ Welsh, JA Joseph, JR Espinosa, S Wittmann, E de Csilléry, A Sridhar, Z Toprakcioglu, G Gudiškytė, MA Czekalska, WE Arter, J Guillén-Boixet, TM Franzmann, S Qamar, PS George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
– Nat Commun
(2021)
12,
1085
(doi: 10.1038/s41467-021-21181-9)
Valency and binding affinity variations can regulate the multilayered organization of protein condensates with many components
I Sanchez-Burgos, JR Espinosa, JA Joseph, R Collepardo-Guevara
– Biomolecules
(2021)
11,
278
(doi: 10.3390/biom11020278)
Thermodynamics and kinetics of phase separation of protein-RNA mixtures by a minimal model
JA Joseph, JR Espinosa, I Sanchez-Burgos, A Garaizar, D Frenkel, R Collepardo-Guevara
– Biophys J
(2021)
120,
1219
(doi: 10.1016/j.bpj.2021.01.031)
Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
S Farr, E Woods, J Joseph, A Garaizar, R Collepardo-Guevara
(2020)
(doi: 10.1101/2020.11.23.391599)
DNA binds to a specific site of the adhesive blood-protein von Willebrand factor guided by electrostatic interactions (vol 48, pg 7333, 2020)
A Sandoval-Pérez, RML Berger, A Garaizar, SE Farr, MA Brehm, G König, SW Schneider, R Collepardo-Guevara, V Huck, JO Rädler, C Aponte-Santamaría
– Nucleic Acids Research
(2020)
48,
gkaa988-
(doi: 10.1093/nar/gkaa988)
Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence
S Lichtinger, A Garaizar, R Collepardo-Guevara, A Reinhardt
(2020)
(doi: 10.1101/2020.10.20.347542)
Expansion of intrinsically disordered proteins increases the range of stability of liquid⇓liquid phase separation
A Garaizar, I Sanchez-Burgos, R Collepardo-Guevara, JR Espinosa
– Molecules (Basel, Switzerland)
(2020)
25,
E4705
(doi: 10.3390/molecules25204705)
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Research Interest Group

Email address

rc597@cam.ac.uk

College

Clare College

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