Yusuf Hamied Department of Chemistry

Professor Rosana Collepardo-Guevara

University Associate Professor

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Designing multiphase biomolecular condensates by coevolution of protein mixtures
PY Chew, JA Joseph, R Collepardo-Guevara, A Reinhardt
(2022)
(doi: 10.1101/2022.04.22.489187)
Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it
AR Tejedor, I Sanchez-Burgos, M Estevez-Espinosa, A Garaizar, R Collepardo-Guevara, J Ramirez, JR Espinosa
(2022)
(doi: 10.1101/2022.03.30.486367)
Multiscale modelling of chromatin organisation: Resolving nucleosomes at near-atomistic resolution inside genes.
J Huertas, EJ Woods, R Collepardo-Guevara
Current Opinion in Cell Biology
(2022)
75
(doi: 10.1016/j.ceb.2022.02.001)
Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates
A Garaizar, JR Espinosa, JA Joseph, R Collepardo-Guevara
Scientific Reports
(2022)
12
(doi: 10.1038/s41598-022-08130-2)
RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins
I Sanchez-Burgos, JR Espinosa, JA Joseph, R Collepardo-Guevara
PLOS Computational Biology
(2022)
18
(doi: 10.1371/journal.pcbi.1009810)
Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy
JA Joseph, A Reinhardt, A Aguirre, PY Chew, KO Russell, JR Espinosa, A Garaizar, R Collepardo-Guevara
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.1214)
Comparison of experimental phase diagrams and residue-level coarse-grained simulations of intrinsically disordered proteins
MJ Maristany, R Collepardo-Guevara, JA Joseph, A Reinhardt
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.408)
Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates.
TJ Welsh, G Krainer, JR Espinosa, JA Joseph, A Sridhar, M Jahnel, WE Arter, KL Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles
Nano letters
(2022)
22
(doi: 10.1021/acs.nanolett.1c03138)
Study on stability, composition, and protein arrangement within bio-condensates formed via liquid-liquid phase separation
IS Burgos, JR Espinosa, A Garaizar, R Collepardo-Guevara, JA Joseph
BIOPHYSICAL JOURNAL
(2022)
121
Deoxyribonucleic Acid Encoded and Size-Defined pi-Stacking of Perylene Diimides
J Gorman, SRE Orsborne, A Sridhar, R Pandya, P Budden, A Ohmann, NA Panjwani, Y Liu, JL Greenfield, S Dowland, V Gray, STJ Ryan, S De Ornellas, AH El-Sagheer, T Brown, JR Nitschke, J Behrends, UF Keyser, A Rao, R Collepardo-Guevara, E Stulz, RH Friend, F Auras
J Am Chem Soc
(2021)
144
(doi: 10.1021/jacs.1c10241)

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rc597@cam.ac.uk

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Clare College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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