Professor Rosana Collepardo-Guevara

University Associate Professor

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.

Professor Collepardo discusses her research

Publications

Thermodynamic origins of two-component multiphase condensates of proteins

PY Chew, JA Joseph, R Collepardo-Guevara, A Reinhardt

Chemical Science

(2023)

1820

(doi: 10.1039/d2sc05873a)

Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation

K Brown, PY Chew, S Ingersoll, JR Espinosa, A Aguirre, T Kutateladze, RC Guevara, X Ren

(2022)

(doi: 10.1101/2022.12.26.521954)

Location and concentration of aromatic-rich segments dictates the percolating inter-molecular network and viscoelastic properties of ageing condensates

S Blazquez, I Sanchez-Burgos, J Ramirez, T Higginbotham, MM Conde, R Collepardo-Guevara, AR Tejedor, JR Espinosa

(2022)

(doi: 10.1101/2022.12.14.520383)

Time-dependent material properties of ageing biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations

AR Tejedor, R Collepardo-Guevara, J Ramírez, JR Espinosa

(2022)

(doi: 10.1101/2022.12.07.519428)

Surfactants or scaffolds? RNAs of different lengths exhibit heterogeneous distributions and play diverse roles in RNA-protein condensates

I Sanchez-Burgos, L Herriott, R Collepardo-Guevara, JR Espinosa

(2022)

(doi: 10.1101/2022.11.09.515827)

Aging can transform single-component protein condensates into multiphase architectures.

A Garaizar, JR Espinosa, JA Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara

Proceedings of the National Academy of Sciences of USA

(2022)

119

e2119800119

(doi: 10.1073/pnas.2119800119)

Designing multiphase biomolecular condensates by coevolution of protein mixtures

PY Chew, JA Joseph, R Collepardo-Guevara, A Reinhardt

(2022)

(doi: 10.1101/2022.04.22.489187)

Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it

AR Tejedor, I Sanchez-Burgos, M Estevez-Espinosa, A Garaizar, R Collepardo-Guevara, J Ramirez, JR Espinosa

(2022)

2022.03.30.486367

(doi: 10.1101/2022.03.30.486367)