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Yusuf Hamied Department of Chemistry

 

Professor Rosana Collepardo-Guevara

Professor of Computational and Molecular Biophysics

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it
AR Tejedor, I Sanchez-Burgos, M Estevez-Espinosa, A Garaizar, R Collepardo-Guevara, J Ramirez, JR Espinosa
(2022)
2022.03.30.486367
(doi: 10.1101/2022.03.30.486367)
Multiscale modelling of chromatin organisation: Resolving nucleosomes at near-atomistic resolution inside genes
J Huertas, EJ Woods, R Collepardo-Guevara
– Curr Opin Cell Biol
(2022)
75,
102067
(doi: 10.1016/j.ceb.2022.02.001)
Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates.
A Garaizar, JR Espinosa, JA Joseph, R Collepardo-Guevara
– Scientific Reports
(2022)
12,
4390
(doi: 10.1038/s41598-022-08130-2)
RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins.
I Sanchez-Burgos, JR Espinosa, JA Joseph, R Collepardo-Guevara
– PLoS Comput Biol
(2022)
18,
e1009810
(doi: 10.1371/journal.pcbi.1009810)
Comparison of experimental phase diagrams and residue-level coarse-grained simulations of intrinsically disordered proteins
MJ Maristany, R Collepardo-Guevara, JA Joseph, A Reinhardt
– Biophysical Journal
(2022)
121,
471A
(doi: 10.1016/j.bpj.2021.11.408)
Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy
JA Joseph, A Reinhardt, A Aguirre, PY Chew, KO Russell, JR Espinosa, A Garaizar, R Collepardo-Guevara
– Biophysical Journal
(2022)
121,
307a
(doi: 10.1016/j.bpj.2021.11.1214)
Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates.
TJ Welsh, G Krainer, JR Espinosa, JA Joseph, A Sridhar, M Jahnel, WE Arter, KL Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles
– Nano Letters
(2022)
22,
612
(doi: 10.1021/acs.nanolett.1c03138)
Study on stability, composition, and protein arrangement within bio-condensates formed via liquid-liquid phase separation
IS Burgos, JR Espinosa, A Garaizar, R Collepardo-Guevara, JA Joseph
– BIOPHYSICAL JOURNAL
(2022)
121,
357A
(link to publication)
Deoxyribonucleic Acid Encoded and Size-Defined π‑Stacking of Perylene Diimides
J Gorman, SRE Orsborne, A Sridhar, R Pandya, P Budden, A Ohmann, NA Panjwani, Y Liu, JL Greenfield, S Dowland, V Gray, STJ Ryan, S De Ornellas, AH El-Sagheer, T Brown, JR Nitschke, J Behrends, UF Keyser, A Rao, R Collepardo-Guevara, E Stulz, RH Friend, F Auras
– J Am Chem Soc
(2021)
144,
368
(doi: 10.1021/jacs.1c10241)
Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy.
J Joseph, A Reinhardt, A Aguirre, PY Chew, K Russell, J Rene Espinosa, A Garaizar, R Collepardo Guevara
– Nature Computational Science
(2021)
1,
732
(doi: 10.1038/s43588-021-00155-3)
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Research Interest Group

Email address

rc597@cam.ac.uk

College

Clare College

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