Professor of Computational and Molecular Biophysics
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Expansion of Intrinsically Disordered Proteins Increases the Range of Stability of Liquid-Liquid Phase Separation
– Molecules (Basel, Switzerland)
(2020)
25,
E4705
(doi: 10.3390/molecules25204705)
DNA binds to a specific site of the adhesive blood-protein von Willebrand factor guided by electrostatic interactions.
– Nucleic acids research
(2020)
48,
gkaa466-
(doi: 10.1093/nar/gkaa466)
Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components.
– Proc Natl Acad Sci U S A
(2020)
117,
13238
(doi: 10.1073/pnas.1917569117)
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
– BIOPHYSICAL JOURNAL
(2020)
120,
28A
(doi: 10.1101/2020.05.04.076299)
Protein disorder-to-order transition enhances the nucleosome-binding affinity of H1
– Nucleic Acids Res
(2020)
48,
5318
(doi: 10.1093/nar/gkaa285)
Surface electrostatics govern the emulsion stability of biomolecular condensates
(2020)
2020.04.20.047910
(doi: 10.1101/2020.04.20.047910)
Emergence of chromatin hierarchical loops from protein disorder and nucleosome asymmetry
– Proceedings of the National Academy of Sciences of the United States of America
(2020)
117,
7216
(doi: 10.1073/pnas.1910044117)
Oligonucleotides can act as superscaffolds that enhance liquid-liquid phase separation of intracellular mixtures
(2020)
2020.01.24.916858
(doi: 10.1101/2020.01.24.916858)
Phosphorylation of Intrinsically Disordered Regions within the Genome
– BIOPHYSICAL JOURNAL
(2020)
118,
296A
Breakdown of the law of rectilinear diameter and related surprises in the liquid-vapor coexistence in systems of patchy particles
– Journal of Chemical Physics
(2019)
150,
224510
(doi: 10.1063/1.5098551)
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