Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
On the reaction of thioacetals with sulphuryl chloride
– Journal of the Chemical Society, Perkin Transactions 1
(1981)
457
(doi: 10.1039/P19810000457)
Experiments on the synthesis of tetracycline. Part 16. Improved photocyclic preparation of 12-keto-derivatives and their deprotection using benzeneseleninic anhydride
– J CHEM SOC PERK T 1
(1981)
1840
(doi: 10.1039/P19810001840)
Cyclisation reactions of alkenyl β-ketoesters involving a novel phenylseleno group migration
– Tetrahedron Letters
(1981)
22,
2601
OXYGEN ATOM TRANSFER FROM IODYLBENZENE TO DIPHENYL DISELENIDE - A CONVENIENT METHOD FOR DEHYDROGENATION OF STEROIDAL 3-KETONES
– Journal of the Chemical Society Chemical Communications
(1981)
1044
(doi: 10.1039/C39810001044)
Synthesis of a trans-decalin as a potential insect antifeedant
– Journal of the Chemical Society Chemical Communications
(1981)
1001
(doi: 10.1039/c39810001001)
THE SYNTHESIS AND DIELS-ALDER REACTIONS OF 2-PROP-2-ENYLIDENE-1,3-DIOXOLAN
– J CHEM SOC PERK T 1
(1981)
1582
(doi: 10.1039/p19810001582)
Synthesis of (±)warburganal
– Tetrahedron Letters
(1981)
22,
3909
AN INTRAMOLECULAR DIELS-ALDER APPROACH TO THE SYNTHESIS OF THE RIGHT HAND HALF OF THE IONOPHORE ANTIBIOTIC X-14547A
– Tetrahedron Letters
(1981)
22,
361
(doi: 10.1016/0040-4039(81)80099-8)
Preparation of lactones via tricarbonyliron–lactone complexes
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1981)
270
(doi: 10.1039/p19810000270)
A CONVENIENT PREPARATION OF 2-HALOENONES FROM ENONES USING PHENYLSELENIUM HALIDES
– Tetrahedron Letters
(1981)
22,
3301
- <
- 100 of 105