Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Synthesis of euryfuran, valdiviolide, and confertifolin
– Tetrahedron Letters
(1981)
22,
4747
Synthesis of cinnamolide and polygodial
– Journal of the Chemical Society, Chemical Communications
(1981)
507
(doi: 10.1039/c39810000507)
Oxygen atom transfer from iodylbenzene to diphenyl diselenide - a convenient method for dehydrogenation of steroidal 3-ketones
– Journal of the Chemical Society Chemical Communications
(1981)
1044
(doi: 10.1039/C39810001044)
Dehydrogenation of steroidal and triterpenoid ketones using benzeneseleninic anhydride
– Journal of the Chemical Society Perkin Transactions 1
(1980)
2209
(doi: 10.1039/p19800002209)
Organosulphur, organoselenium, and organotellurium chemistry
– Annual Reports on the Progress of Chemistry Section B
(1980)
77,
233
(doi: 10.1039/oc9807700233)
Selenium-mediated cyclization reactions of alkenyl-substituted β-ketoesters
– Chemical Communications
(1980)
1173
(doi: 10.1039/C39800001173)
Thermal decomposition of tricarbonyliron lactone complexes
– Chemical Communications
(1980)
299
(doi: 10.1039/c39800000299)
Catalytic oxidation of thiocarbonyl compounds involving the use of 1,2-Dibrometatrachloroethane as a brominating reagent for diaryl teII species
– Tetrahedron Letters
(1980)
21,
1785
Removal of thioacetal protecting groups by benzeneseleninic anhydride
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1980)
1654
(doi: 10.1039/p19800001654)
A new synthetic approach towards adriamycin
– Journal of the Chemical Society Perkin Transactions 1
(1980)
643
(doi: 10.1039/p19800000643)
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