Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
AN INTRAMOLECULAR DIELS-ALDER APPROACH TO THE SYNTHESIS OF THE RIGHT HAND HALF OF THE IONOPHORE ANTIBIOTIC X-14547A
Tetrahedron Letters
(1981)
22
361
(doi: 10.1016/0040-4039(81)80099-8)
Oxidation of ketone and aldehyde hydrazones, oximes, and semicarbazones and of hydroxylamines and hydrazo-compounds, using benzeneseleninic anhydride
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1980)
1212
(doi: 10.1039/p19800001212)
A new synthetic approach towards adriamycin
Journal of the Chemical Society Perkin Transactions 1
(1980)
643
(doi: 10.1039/p19800000643)
Organosulphur, organoselenium, and organotellurium chemistry
Annual Reports on the Progress of Chemistry Section B
(1980)
77
233
(doi: 10.1039/oc9807700233)
CATALYTIC-OXIDATION OF THIOCARBONYL COMPOUNDS INVOLVING THE USE OF 1,2-DIBROMOTETRACHLOROETHANE AS A BROMINATING REAGENT FOR DIARYL TEII SPECIES
Tetrahedron Letters
(1980)
21
1785
Formation of β-lactams from tricarbonyliron lactone complexes
J. Chem. Soc., Chem. Commun.
(1980)
297
(doi: 10.1039/c39800000297)
Thermal decomposition of tricarbonyliron lactone complexes
Journal of the Chemical Society, Chemical Communications
(1980)
299
(doi: 10.1039/c39800000299)
New cyclization procedure for alkenyl-substituted β-dicarbonyl compounds using N-phenylselenophthalimide
J. Chem. Soc., Chem. Commun.
(1980)
1028
(doi: 10.1039/c39800001028)
Selenium-mediated cyclization reactions of alkenyl-substituted β-ketoesters
Chemical Communications
(1980)
1173
(doi: 10.1039/c39800001173)
Dehydrogenation of steroidal and triterpenoid ketones using benzeneseleninic anhydride
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1980)
2209
(doi: 10.1039/p19800002209)
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