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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Oxidation of benzylic hydrocarbons with benzeneseleninic anhydride and related reactions
DHR BARTON, RAHF HUI, SV LEY
– Journal of the Chemical Society, Perkin Transactions 1
(1982)
2179
The X-ray structure and absolute configuration of insect antifeedant clerodane diterpenoids from Teucrium africanum
JR HANSON, DEA RIVETT, SV LEY, DJ WILLIAMS
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1982)
1005
A practical catalytic method for the preparation of steroidal 1,4-dien-3-ones by oxygen atom transfer from iodoxybenzene to diphenyl diselenide
DHR BARTON, CRA GODFREY, JW MORZYCKI, WB MOTHERWELL, SV LEY
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1982)
1947
A short syntesis of (±)-hirsutene involving the use of an organoselenium-mediated cyclization reaction
SV LEY, PJ MURRAY
– J. Chem. Soc., Chem. Commun.
(1982)
1252
Thermal rearrangement reactions of tricarbonyliron lactone complexes
GD ANNIS, SV LEY, CR SELF, R SIVARAMAKRISHNAN, DJ WILLIAMS
– J CHEM SOC PERK T 1
(1982)
1355
A conformational study of elaiophylin by X-ray crystallography and difference 1H NMR methods; observation of a selective sign reversal of the nuclear overhauser effect
SV LEY, D NEUHAUS, DJ WILLIAMS
– Tetrahedron Letters
(1982)
23,
1207
SYNTHESIS OF (CIS-6-METHYLTETRAHYDROPYRAN-2-YL)ACETIC ACID INVOLVING THE USE OF AN ORGANOSELENIUM-MEDIATED CYCLIZATION REACTION
SV LEY, B LYGO, H MOLINES, JA MORTON
– Journal of the Chemical Society, Chemical Communications
(1982)
1251
Synthesis of polyoxygenated trans -decalins as potential insect antifeedants
SV LEY, D NEUHAUS, NS SIMPKINS, AJ WHITTLE
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1982)
2157
Synthesis of substituted cis-decalins as potential insect antifeedants
WP JACKSON, SV LEY
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1981)
1516
Oxidation of phenols, pyrocatechols, and hydroquinones to ortho -quinones using benzeneseleninic anhydride
DHR BARTON, AG BREWSTER, SV LEY, CM READ, MN ROSENFELD
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1981)
1473
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk