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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

An unexpected rearrangement of 4-alkylaminoindoles
SV LEY, RA PORTER
– Chemical Communications
(1982)
1356
Synthesis of methyl-1,6-dioxaspiro[4,5]decanes using organoselenium mediated cyclization reactions
SV LEY, B LYGO
– Tetrahedron Letters
(1982)
23,
4625
Oxidation of benzylic hydrocarbons with benzeneseleninic anhydride and related reactions
DHR BARTON, RAHF HUI, SV LEY
– Journal of the Chemical Society, Perkin Transactions 1
(1982)
2179
Synthesis of ( cis -6-methyltetrahydropyran-2-yl)acetic acid involving the use of an organoselenium-mediated cyclization reaction
SV LEY, B LYGO, H MOLINES, JA MORTON
– Journal of the Chemical Society - Series Chemical Communications
(1982)
1251
The X-ray structure and absolute configuration of insect antifeedant clerodane diterpenoids from Teucrium africanum
JR HANSON, DEA RIVETT, SV LEY, DJ WILLIAMS
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1982)
1005
Dehydrogenation of lactones using benzeneseleninic anhydride. X-Ray crystal structure of 3β-acetoxy-14α-hydroxy-17a-oxa-D-homo-5α-androst-15-en-17-one
DHR BARTON, RAHF HUI, SV LEY
– J CHEM SOC PERK T 1
(1982)
1919
A short syntesis of (±)-hirsutene involving the use of an organoselenium-mediated cyclization reaction
SV LEY, PJ MURRAY
– Journal of the Chemical Society - Series Chemical Communications
(1982)
1252
Oxidation of phenols, pyrocatechols, and hydroquinones to ortho -quinones using benzeneseleninic anhydride
DHR BARTON, AG BREWSTER, SV LEY, CM READ, MN ROSENFELD
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1981)
1473
Experiments on the synthesis of tetracycline. Part 16. Improved photocyclic preparation of 12-keto-derivatives and their deprotection using benzeneseleninic anhydride
DHR BARTON, MT BIELSKA, JM CARDOSO, NJ CUSSANS, SV LEY
– Journal of the Chemical Society, Perkin Transactions 1
(1981)
1840
On the reaction of thioacetals with sulphuryl chloride
PC BULMANPAGE, SV LEY, JA MORTON, DJ WILLIAMS
– J CHEM SOC PERK T 1
(1981)
457
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk