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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Total synthesis of the structurally unique ionophore antibiotic X-14547 A
MP EDWARDS, SV LEY, SG LISTER, BD PALMER
– J. Chem. Soc., Chem. Commun.
(1983)
630
The Diels–Alder route to drimane related sesquiterpenes; synthesis of cinnamolide, polygodial, isodrimeninol, drimenin and warburganal
DM HOLLINSHEAD, SC HOWELL, SV LEY, M MAHON, NM RATCLIFFE, PA WORTHINGTON
– Journal of the Chemical Society, Perkin Transactions 1
(1983)
1579
STEREOCHEMISTRY OF A 5,5,10-TRIMETHYL-2-DECALONE BY PROTON NUCLEAR MAGNETIC-RESONANCE - A NEW APPLICATION OF INDOR DIFFERENCE SPECTROSCOPY
SV LEY, AJ WHITTLE, GE HAWKES
– J CHEM RES-S
(1983)
210
The total synthesis of the clerodane diterpene insect antifeedant ajugarin I
SV LEY, NS SIMPKINS, AJ WHITTLE
– Chemical Communications
(1983)
503
Synthesis of the drimane-related sesquiterpenes euryfuran, confertifolin, and valdiviolide
SV LEY, M MAHON
– J CHEM SOC PERK T 1
(1983)
1379
Regiospecific alkylation of β-ketothioesters and use in the synthesis of acyl-tetronic acids
PM BOOTH, CMJ FOX, SV LEY
– Tetrahedron Letters
(1983)
24,
5143
A CONFORMATIONAL STUDY OF ELAIOPHYLIN BY X-RAY CRYSTALLOGRAPHY AND DIFFERENCE H-1-NMR METHODS - OBSERVATION OF A SELECTIVE SIGN REVERSAL OF THE NUCLEAR OVERHAUSER EFFECT
SV LEY, D NEUHAUS, DJ WILLIAMS
– Tetrahedron Letters
(1982)
23,
1207
Thermal rearrangement reactions of tricarbonyliron lactone complexes
GD ANNIS, SV LEY, CR SELF, R SIVARAMAKRISHNAN, DJ WILLIAMS
– Journal of the Chemical Society Perkin Transactions 1
(1982)
1355
A PRACTICAL CATALYTIC METHOD FOR THE PREPARATION OF STEROIDAL 1,4-DIEN-3-ONES BY OXYGEN ATOM TRANSFER FROM IODOXYBENZENE TO DIPHENYL DISELENIDE
DHR BARTON, CRA GODFREY, JW MORZYCKI, WB MOTHERWELL, SV LEY
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1982)
1947
Synthesis of polyoxygenated trans-decalins as potential insect antifeedants
SV LEY, D NEUHAUS, NS SIMPKINS, AJ WHITTLE
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1982)
2157
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk