Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A convenient preparation of 2-haloenones from enones using phenylselenium halides
Tetrahedron Letters
(1981)
22
3301
Synthesis of euryfuran, valdiviolide, and confertifolin
Tetrahedron Letters
(1981)
22
4747
Cyclisation reactions of alkenyl β-ketoesters involving a novel phenylseleno group migration
Tetrahedron Letters
(1981)
22
2601
AN INTRAMOLECULAR DIELS-ALDER APPROACH TO THE SYNTHESIS OF THE RIGHT HAND HALF OF THE IONOPHORE ANTIBIOTIC X-14547A
Tetrahedron Letters
(1981)
22
361
(doi: 10.1016/0040-4039(81)80099-8)
The synthesis and Diels-Alder reactions of 2-prop-2-enylidene-1,3-dioxolan
J CHEM SOC PERK T 1
(1981)
1582
(doi: 10.1039/p19810001582)
Diaryl telluroxides as new mild oxidising reagents
Tetrahedron
(1981)
37
213
(doi: 10.1016/0040-4020(81)85057-0)
Synthesis of cinnamolide and polygodial
Journal of the Chemical Society, Chemical Communications
(1981)
507
(doi: 10.1039/c39810000507)
CATALYTIC-OXIDATION OF THIOCARBONYL COMPOUNDS INVOLVING THE USE OF 1,2-DIBROMOTETRACHLOROETHANE AS A BROMINATING REAGENT FOR DIARYL TEII SPECIES
Tetrahedron Letters
(1980)
21
1785
Formation of β-lactams from tricarbonyliron lactone complexes
Chemical Communications
(1980)
297
(doi: 10.1039/c39800000297)
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