Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Total syntheses of natural products containing spirocarbocycles.
– Org Biomol Chem
(2015)
13,
9907
(doi: 10.1039/c5ob01524c)
Development of a flow method for the hydroboration/oxidation of olefins
– Organic & Biomolecular Chemistry
(2015)
13,
3871
(doi: 10.1039/c5ob00170f)
A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions
– Organic & Biomolecular Chemistry
(2015)
13,
1768
(doi: 10.1039/c4ob02376e)
Development of a web-based platform for studying lithiation reactions in silico.
– Chem Commun (Camb)
(2015)
51,
7172
(doi: 10.1039/c5cc00782h)
Back Pressure Regulation of Slurry‐Forming Reactions in Continuous Flow
– Chemical Engineering & Technology
(2014)
38,
259
(doi: 10.1002/ceat.201400445)
Achieving Continuous Manufacturing: Technologies and Approaches for Synthesis, Workup, and Isolation of Drug Substance May 20-21, 2014 Continuous Manufacturing Symposium
– J Pharm Sci
(2014)
104,
781
(doi: 10.1002/jps.24252)
Total Syntheses of Linear Polythiazole/Oxazole Plantazolicin A and Its Biosynthetic Precursor Plantazolicin B
– Angewandte Chemie (International ed. in English)
(2014)
54,
1284
(doi: 10.1002/anie.201410063)
Sustainable Synthesis of Thioimidazoles via Carbohydrate-Based Multicomponent Reactions
– Org Lett
(2014)
16,
6076
(doi: 10.1021/ol502845h)
Flow chemistry as a discovery tool to access sp2–sp3cross-coupling reactions via diazo compounds
– Chemical Science
(2014)
6,
1120
(doi: 10.1039/c4sc03072a)
A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences
– Angewandte Chemie (International ed. in English)
(2014)
54,
144
(doi: 10.1002/anie.201409356)
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