Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences
– Angewandte Chemie (International ed. in English)
(2014)
54,
144
(doi: 10.1002/anie.201409356)
Reconfiguration of a Continuous Flow Platform for Extended Operation: Application to a Cryogenic Fluorine-Directed ortho-Lithiation Reaction
– Organic Process Research and Development
(2014)
18,
1221
(doi: 10.1021/op500221s)
Design and application of a low-temperature continuous flow chemistry platform
– Organic Process Research and Development
(2014)
18,
1211
(doi: 10.1021/op500213j)
A general continuous flow method for palladium catalysed carbonylation reactions using single and multiple tube-in-tube gas-liquid microreactors
– European Journal of Organic Chemistry
(2014)
2014,
6418
(doi: 10.1002/ejoc.201402804)
Regioselective preparation of saturated spirocyclic and ring-expanded fused pyrazoles
– Journal of Organic Chemistry
(2014)
79,
8800
(doi: 10.1021/jo501624t)
Flow chemistry meets advanced functional materials
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2014)
20,
12348
(doi: 10.1002/chem.201402801)
Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology
– Organic Letters
(2014)
16,
4618
(doi: 10.1021/ol502201d)
Process intensification for the continuous flow hydrogenation of ethyl nicotinate
– Organic Process Research & Development
(2014)
18,
1560
(doi: 10.1021/op500208j)
Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations
– Molecules
(2014)
19,
9736
(doi: 10.3390/molecules19079736)
Synthesis and Use of a Trifluoromethylated Azomethine Ylide Precursor: Ethyl 1-Benzyl-trans-5- (trifluoromethyl)pyrrolidine-3-carboxylate
– Organic Syntheses
(2014)
91,
162
(doi: 10.15277/orgsyn.091.0162)
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