Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Large-Scale Synthesis of Crystalline 1,2,3,4,6,7-Hexa-

C Stanetty, IR Baxendale

European journal of organic chemistry

(2015)

2015

2718

(doi: 10.1002/ejoc.201500024)

Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines

M Baumann, AM Rodriguez Garcia, IR Baxendale

Org Biomol Chem

(2015)

4231

(doi: 10.1039/c5ob00245a)

Syn-Ethyl 1-hydroxy-7-methoxy-2,3-dihydro-1H-pyrrolo[3,4-b]quinolone-3-carboxylate HCL Salt

M Baumann, I Baxendale

Molbank

(2015)

2015

m846

(doi: 10.3390/M846)

Chemistry in a changing world

SV Ley, RM Myers, DE Fitzpatrick

Actualite Chimique

(2015)

Back pressure regulation of slurry-forming reactions in continuous flow

BJ Deadman, DL Browne, IR Baxendale, SV Ley

Chemical Engineering and Technology

(2015)

259

(doi: 10.1002/ceat.201400445)

Design, synthesis, and evaluation of tetrasubstituted pyridines as potent 5-HT2C receptor agonists

G Rouquet, DE Moore, M Spain, DM Allwood, C Battilocchio, DC Blakemore, PV Fish, S Jenkinson, AS Jessiman, SV Ley, G McMurray, RI Storer

ACS medicinal chemistry letters

(2015)

329

(doi: 10.1021/ml500507v)

Flow chemistry: Intelligent processing of gas-liquid transformations using a tube-in-tube reactor

M Brzozowski, M O'Brien, SV Ley, A Polyzos

Acc Chem Res

(2015)

349

(doi: 10.1021/ar500359m)

Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2.

MS Christodoulou, F Calogero, M Baumann, AN García-Argáez, S Pieraccini, M Sironi, F Dapiaggi, R Bucci, G Broggini, S Gazzola, S Liekens, A Silvani, M Lahtela-Kakkonen, N Martinet, A Nonell-Canals, E Santamaría-Navarro, IR Baxendale, L Dalla Via, D Passarella

European journal of medicinal chemistry

(2015)

766

(doi: 10.1016/j.ejmech.2015.01.038)

Organic synthesis: march of the machines.

SV Ley, DE Fitzpatrick, RJ Ingham, RM Myers

Angewandte Chemie - International Edition

(2015)

3449

(doi: 10.1002/anie.201410744)

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions.

S Glöckner, DN Tran, RJ Ingham, S Fenner, ZE Wilson, C Battilocchio, SV Ley

Organic and Biomolecular Chemistry

(2015)

207

(doi: 10.1039/c4ob02105c)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

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