Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Syn-Ethyl 1-hydroxy-7-methoxy-2,3-dihydro-1H-pyrrolo[3,4-b]quinolone-3-carboxylate HCl Salt

M Baumann, IR Baxendale

– Molbank

(2015)

2015,

M846

(doi: 10.3390/M846)

Chemistry in a changing world

SV Ley, RM Myers, DE Fitzpatrick

– Actualite Chimique

(2015)

Back pressure regulation of slurry-forming reactions in continuous flow

BJ Deadman, DL Browne, IR Baxendale, SV Ley

– Chemical Engineering and Technology

(2015)

38,

259

(doi: 10.1002/ceat.201400445)

Flow chemistry: Intelligent processing of gas-liquid transformations using a tube-in-tube reactor

M Brzozowski, M O'Brien, SV Ley, A Polyzos

– Acc Chem Res

(2015)

48,

349

(doi: 10.1021/ar500359m)

Design, synthesis, and evaluation of tetrasubstituted pyridines as potent 5-HT2C receptor agonists

G Rouquet, DE Moore, M Spain, DM Allwood, C Battilocchio, DC Blakemore, PV Fish, S Jenkinson, AS Jessiman, SV Ley, G McMurray, RI Storer

– ACS Med Chem Lett

(2015)

329

(doi: 10.1021/ml500507v)

Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2

MS Christodoulou, F Calogero, M Baumann, AN García-Argáez, S Pieraccini, M Sironi, F Dapiaggi, R Bucci, G Broggini, S Gazzola, S Liekens, A Silvani, M Lahtela-Kakkonen, N Martinet, A Nonell-Canals, E Santamaría-Navarro, IR Baxendale, L Dalla Via, D Passarella

– European journal of medicinal chemistry

(2015)

92,

766

(doi: 10.1016/j.ejmech.2015.01.038)